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Reproduction of Epstein-Barr Virus Infection and Pathogenesis in Humanized Mice

Fujiwara S

Epstein-Barr virus (EBV) is etiologically associated with a variety of diseases including lymphoproliferative diseases, lymphomas, carcinomas, and autoimmune diseases. Humans are the only natural host of EBV and limited species...
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Erratum: Mesenchymal Stem Cell Lines Isolated by Different Isolation Methods Show Variations in the Regulation of Graft-versus-host Disease

Yoo HS, Yi T, Cho YK, Kim WC, Song SU, Jeon MS

Typographical error has been detected in acknowledgements.
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NF-kappaB Activation in T Helper 17 Cell Differentiation

Park SH, Cho G, Park SG

CD28/T cell receptor ligation activates the NF-kappaB signaling cascade during CD4 T cell activation. NF-kappaB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently,...
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Co-stimulation of TLR4 and Dectin-1 Induces the Production of Inflammatory Cytokines but not TGF-beta for Th17 Cell Differentiation

Chang J, Kim BM, Chang CH

Collaboration of TLR and non-TLR pathways in innate immune cells, which acts in concert for the induction of inflammatory cytokines, can mount a specific adaptive immune response tailored to a...
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Potential Role of Bacterial Infection in Autoimmune Diseases: A New Aspect of Molecular Mimicry

Alam J, Kim YC, Choi Y

Molecular mimicry is an attractive mechanism for triggering autoimmunity. In this review, we explore the potential role of evolutionary conserved bacterial proteins in the production of autoantibodies with focus on...
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Insights into the Role of Follicular Helper T Cells in Autoimmunity

Park HJ, Kim DH, Lim SH, Kim WJ, Youn J, Choi YS, Choi JM

Follicular helper T (TFH) cells are recently highlighted as their crucial role for humoral immunity to infection as well as their abnormal control to induce autoimmune disease. During an infection,...
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Molecular Characterization of Neurally Differentiated Human Bone Marrow-derived Clonal Mesenchymal Stem Cells

Yi T, Lee HJ, Cho YK, Jeon MS, Song SU

Bone marrow-derived mesenchymal stem cells (MSCs) are multipotent, with the ability to differentiate into different cell types. Additionally, the immunomodulatory activity of MSCs can downregulate inflammatory responses. The use of...
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Gut-residing Microbes Alter the Host Susceptibility to Autoantibody-mediated Arthritis

Lee H, Jin BE, Jang E, Lee AR, Han DS, Kim HY, Youn J

K/BxN serum can transfer arthritis to normal mice owing to the abundant autoantibodies it contains, which trigger innate inflammatory cascades in joints. Little is known about whether gut-residing microbes affect...
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Ursodeoxycholic Acid Ameliorates Pain Severity and Cartilage Degeneration in Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Moon SJ, Jeong JH, Jhun JY, Yang EJ, Min JK, Choi JY, Cho ML

Osteoarthritis (OA) is a degenerative joint disease characterized by a progressive loss of cartilage. And, increased oxidative stress plays a relevant role in the pathogenesis of OA. Ursodeoxycholic acid (UDCA)...
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