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Inhibition of Leukocyte Adhesion by Developmental Endothelial Locus-1 (Del-1)

Choi EY

The leukocyte adhesion to endothelium is pivotal in leukocyte recruitment which takes place during inflammatory, autoimmune and infectious conditions. The interaction between leukocytes and endothelium requires an array of adhesion...
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The Prospects of Vitamin C in Cancer Therapy

Lee WJ

Ascorbate (vitamin C) is a cofactor for a number of metabolic enzymes and is an indisputable essential vitamin C for humans. However, the potential of ascorbate as an anticancer agent...
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Enhancement of DNA Vaccine-induced Immune Responses by Influenza Virus NP Gene

Choi SY, Suh YS, Cho JH, Jin HT, Chang J, Sung YC

DNA immunization induces B and T cell responses to various pathogens and tumors. However, these responses are known to be relatively weak and often transient. Thus, novel strategies are necessary...
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Tumor Therapy Applying Membrane-bound Form of Cytokines

Kim YS

Tumor therapy using cytokines has been developed for last two decades. Several recombinant cytokines and tumor cell vaccines produced by cytokine gene transfer have been in clinical trials, but several...
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Nitric Oxide Synthesis is Modulated by 1,25-Dihydroxyvitamin D3 and Interferon-gamma in Human Macrophages after Mycobacterial Infection

Lee JS, Yang CS, Shin DM, Yuk JM, Son JW, Jo EK

BACKGROUND: Little information is available the role of Nitric Oxide (NO) in host defenses during human tuberculosis (TB) infection. We investigated the modulating factor(s) affecting NO synthase (iNOS) induction in...
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Production of Monoclonal Antibodies Specific to FimA of Porphyromonas gingivalis and Their Inhibitory Activity on Bacterial Binding

Koh EM, Kim J, Lee JY, Kim TG

BACKGROUND: The FimA of Porphyromonas gingivalis is a crucial pathogenic component of the bacteria and has been implicated as a target for vaccine development against the periodontal diseases. METHODS: In this...
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Prophylactic and Therapeutic Potential of Asp f1 Epitopes in Naive and Sensitized BALB/c Mice

Chaudhary , Mahajan L, Madan T, Kumar A, Raghava GP, Katti SB, Haq W, Sarma PU

BACKGROUND: The present study examines a hypothesis that short allergen-derived peptides may shift an Aspergillus fumigatus (Afu-) specific TH2 response towards a protective TH1. Five overlapping peptides (P1-P5) derived from...
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