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Generation of Renal Cell Carcinoma-specific CD4+ /CD8+ T Cells Restricted by an HLA-39 from a RCC Patient Vaccinated with GM-CSF Gene-Transduced Tumor Cells

Jun DY, Moutner J, Jaffee E

BACKGROUND: Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene- transduced tumor cell vaccines induce very potent systemic anti-tumor immunity in preclinical and clinical models. Our previous phase I clinical trial in patients with...
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Umbilical Cord Blood Transplantation

Ahn HS, Shin HY

The number of umbilical cord blood transplantation is increasing worldwide as it has expanded the ability of the transplantaion community to meet the growing needs of their patients. Clinical data...
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Characterization of Anti-anti-idiotypic Antibodies (Ab3) Induced by Immunization of Anti-idiotypic Antibodies (Ab2) Mimicking Disialoganglioside GD2

Park YS

BACKGROUND: Disialoganglioside GD2 is a tumor-associated antigen that is overexpressed on tumor cells of neuroectodermal origin, such as melanoma and neuroblastoma. Anti-idiotypic antibodies that mimic GD2 may induce more effective...
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Immune Stimulating Efficacy of Soluble beta-1,3-glucans

Shim JH, Choi WA, Kim JW, Lee HS, Baek TW, Cho MC, Lee KA, Sang BC, Yoon DY

BACKGROUND: beta-1,3-glucans are well known to enhance the immune reactions, resulting in antitumor, antibacterial, antiviral, anticoagulatory and wound healing activities. beta-1, 3-glucans have various activities depending on molecular weight, degree...
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Studies on the Cellular Immune Response in Animal Model of Arthritis after the Induction of Oral Tolerance

Min SY, Hwang SY, Lee JS, Kim JY, Lee KE, Kim KW, Kim YH, Do JH, Kim HY

Oral administration of antigen has long been considered as a promising alternative for the treatment of chronic autoimmune diseases including rheumatoid arthritis (RA), and oral application of type II collagen...
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Apo-1/Fas (CD95) Gene Polymorphism in Korean Knee Osteoarthritis Patients

Hong SJ, Yang HI, Yim SV, Chung JH, Jung YO, Kim HY

BACKGROUND: Apoptosis has been implicated in pathogenesis of various disease. Apo-1/Fas (CD95) is one of the main pathway of apoptosis. To examine the possible relationship between Apo-1/Fas (CD95) and primary...
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N-Region Addition in Immunoglobulin Kappa Light Chains in B Cell Subsets in Rheumatoid Arthritis: Evidence for Over-expression of TDT in B Lineage

Lee CW, Bridges SL

BACKGROUND: Unusually high amounts of N region addition and CDR3 length diversity were found in immunoglobulin (Ig) light chain Vk and Jk joins in patients with rheumatoid arthritis (RA). We...
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Influence of Immunity Induced at Priming Step on Mucosal Immunization of Heterologous Prime-Boost Regimens

Eo SK

BACKGROUND: The usefulness of DNA vaccine at priming step of heterologous prime-boost vaccination led to DNA vaccine closer to practical reality. DNA vaccine priming followed by recombinant viral vector boosting...
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Terminal Protein-specific scFv Production by Phage Display

Lee MS, Kwon MH, Park S, Shin HJ, Kim HI

BACKGROUND: One of the important factors in the prognosis of chronic hepatitis B patient is the degree of replication of hepatitis B virus (HBV). It has been known that HBV...
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Distribution of HLA-DQA1*01, *03, *05 and DQB1*02 Subtypes and the Associated Haplotypes in the Korean Population

Pyo CW, Chung SY, Hur SS, Kim HJ, Choi JY, Kim YK, Yoo HJ, Choi HB, Kim TG

BACKGROUND: As all HLA class II genes, the DQ genes show their polymorphic variation mainly in the second exon, which encodes the first extracellular domain of the molecule. PCR-SSOP (Polymerase...
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Effects of Cyclosporin A, FK506, and 3-Deazaadenosine on Acute Graft-versus-host Disease and Survival in Allogeneic Murine Hematopoietic Stem Cell Transplantation

Jin JY, Jeong DC, Eom HS, Chung NG, Park SJ, Choi BO, Min WS, Kim HK, Kim CC, Han CW

BACKGROUND: We investigated the effect of donor marrow T cell depletion, administration of FK506, cyclosporin A (CSA), and 3-deazaadenosine (DZA) on graft versus host disease (GVHD) after allogeneic murine hematopoietic...
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