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3C8, a new monoclonal antibody directed against a follicular dendritic cell line, HK

Lee IY, Lee JH, Park WS, Nam EC, Shin YO, Choe JS

BACKGROUND: Follicular dendritic cells (FDCs) play key roles during T cell-dependent humoral immune responses by allowing antigen-specific B cells to survive, proliferate, and differentiate within the FDC networks of secondary...
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Generation and Characterization of 1H8 monoclonal antibody against human bone marrow stromal cells

Kang HS, Choi IP

BACKGROUND: Bone marrow stromal cells (BMSCs) express many cell surface molecules, which regulate the proliferation and differentiation of immune cells within the bone marrow. METHODS: To identify cell surface molecules, which...
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Immature thymocyte antigen, JL1, as a possible immunodiagnostic and immunotherapeutic target for leukemia

Shin YK, Choi EY, Kim SH, Park SH

The identification of tumor-specific antigens has represented a critical milestone in cancer diagnosis and therapy. Clinical research in this area for leukemia has also been driven over the past few...
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Usage of T Cell receptor repertoire is restricted in synovial lymphocytes in rheumatoid arthritis

Kwon DH, Lee SK, Kim SJ, Choi IH

BACKGROUND: Rheumatoid arthritis is an autoimmune disease characterized by a chronic inflammatory process, primarily involving the synovial membrane of peripheral joints, where T cell activation is found. To address the...
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The healing effect of rhGM - CSF on uninfected wounds

Han SK, Kim BS, Kim AR, Seo JH, Choi CW, Shin SW, Kim YH, Kim WK, Kim JS

BACKGROUND: rhGM-CSF has been shown to enhance the migration and proliferation of endothelial cells and to promote keratinocyte growth. This study was tried to evaluate the effect of rhGM-CSF dressing...
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The increased expression of CD99 in a differentiated neuroblastoma cell line

Choi EY, Lee IS

BACKGROUND: The human mic2 gene is a pseudoautosomal gene that encodes a cell surface antigen, CD99. High levels of CD99 constitute a tumor marker in Ewing s sarcoma (ES). We...
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The Effect of retinoic acid on the expression of cell adhesion molecules and binding to peritoneal mesothelium in gastric cancer cells

Hong YS, Park CH, Park JN, Lee KS, Kim IC

BACKGROUND: Peritoneal metastasis is one of the maj or types of the stomach cancer recurrence and the role of the adhesion molecules is thought to be very much important in...
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Definition of the peptide mimotope of cellular receptor for hepatitis C virus E2 protein using random peptide library

Lee IH, Paik JE, Seol SY, Seog DH, Park SG, choi IH

BACKGROUND: Hepatitis C virus(HCV), a family of Flaviviridae, has a host cell-derived envelope containing a positive-stranded RNA genome, and has been known as the maj or etiological agent for chronic...
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Resurrection of antibody as a therapeutic drug

Chung HK, Chung JH

Currently 18 monoclonal antibodies were approved by FDA for inj ection into humans for therapeutic or diagnostic purpose. And 146 clinical trials are under way to evaluate the efficacy of...
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Antitunor effect of carcinoma cells transduced with herpes simplex virus - thymidine kinase by gancyclovir and radiation

Lee JW, Oh ST, Ahn CH, Lim KW, Cho HI, Kim GR, Kim TG

BACKGROUND: Many types of cancer become resistant to current chemotherapeutic and radiotherapeutic intervention. To overcome this situation application of gene therapy by the introduction of suicide genes followed by their...
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Generation and maintenance of type II collagen-specific T-cell line expressing conserved TCR-CDR3 motifs among patients with rheumatoid arthritis Author

Kim SH, Cho ML, Youn JH, Park SH, Hwang SY, Kim HY, Cho CS

BACKGROUND: To determine the molecular structure of type II collagen-specific T-cell receptors associated with rheumatoid arthritis (RA). METHODS: We generated CII-specific T-cell lines of 8 RA patient s by prolonged in...
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Analysis of stromal Cells Developed from Cord Blood CD34+ Cells

Ryu KH, Park SJ, Kim KH, Seoh JY, Khan M, Shin HY, Ahn HS

BACKGROUND: Cytokine-mediated ex vivo expansion has been proposed as a means of increasing the number of cord blood (CB) hematopoietic stem cells for transplantation. As well as stem cell number,...
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