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Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases

Kang MJ

Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functions in the living system. Recently, our understanding of the molecular mechanisms underlying...
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Diagnosis and treatment of interstitial lung disease: focusing on idiopathic pulmonary fibrosis

Kang HR, Choi SM

Interstitial lung disease (ILD) is a rare condition characterized by extensive inflammation and fibrosis mainly involving the pulmonary interstitium or alveoli. Usually, patients with ILD clinically present with chronic cough...
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The Clinical Efficacy of Pulmonary Hypertension-Specific Agents in Idiopathic Pulmonary Fibrosis: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Lee J, Song JU

BACKGROUND: Pulmonary hypertension (PH) is common in patients with idiopathic pulmonary fibrosis (IPF) and is associated with poor outcomes. This study was performed to determine the clinical efficacy of PH-specific...
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Pharmacological treatment of pulmonary fibrosis

Choi WI

Idiopathic pulmonary fibrosis (IPF) is a condition that has been described as alveolar collapse and thickening, which correlate with dysregulated surfactant production and injury to type 2 alveolar cells. As...
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Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1Pâ‚‚) Attenuates Bleomycin-Induced Pulmonary Fibrosis

Park SJ, Im DS

Sphingosine 1-phosphate (S1P) levels are often found to be elevated in serum, bronchoalveolar lavage, and lung tissue of idiopathic pulmonary fibrosis patients and experimental mouse models. Although the roles of...
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Bleomycin Inhibits Proliferation via Schlafen-Mediated Cell Cycle Arrest in Mouse Alveolar Epithelial Cells

Jang S, Ryu SM, Lee J, Lee H, Hong SH, Ha KS, Park WS, Han ET, Yang SR

BACKGROUND: Idiopathic pulmonary fibrosis involves irreversible alveolar destruction. Although alveolar epithelial type II cells are key functional participants within the lung parenchyma, how epithelial cells are affected upon bleomycin (BLM)...
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Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 2. Idiopathic Pulmonary Fibrosis

Lee SH, Yeo Y, Kim TH, Lee HL, Lee JH, Park YB, Park JS, Kim YH, Song JW, Jhun BW, Kim HJ, Park J, Uh ST, Kim YW, Kim DS, Park MS, Korean Interstitial Lung Diseases Study Group

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia, which presents with a progressive worsening dyspnea, and thus a poor outcome. The members of the Korean Academy of...
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New Diagnostic Guidelines for Idiopathic Pulmonary Fibrosis

Kwon BS, Song JW

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease characterized by worsening lung function and dyspnea. The prognosis of IPF patients is poor, as median survival is approximately...
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Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis

Yang JA, Lee JS, Park JK, Lee EB, Song YW, Lee EY

BACKGROUND/AIMS: To analyze clinical characteristics of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA), especially in patients with poor prognosis. METHODS: Seventy-seven RA patients with ILD and 231 age, sex,...
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Long-Term Outcomes of Adult Lung Transplantation Recipients: A Single-Center Experience in South Korea

Jo KW, Hong SB, Kim DK, Jung SH, Kim HR, Choi SH, Lee GD, Lee SO, Do KH, Chae EJ, Choi IC, Choi DK, Kim IO, Park SI, Shim TS

BACKGROUND: Recently, the number of lung transplants in South Korea has increased. However, the long-term outcome data is limited. In this study, we aimed to investigate the long-term outcomes of...
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Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 3. Idiopathic Nonspecific Interstitial Pneumonia

Lee J, Kim YH, Kang JY, Jegal Y, Park SY, on behalf of Korean Interstitial Lung Diseases Study Group

Idiopathic nonspecific interstitial pneumonia (NSIP) is one of the varieties of idiopathic interstitial pneumonias. Diagnosis of idiopathic NSIP can be done via multidisciplinary approach in which the clinical, radiologic, and...
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Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 1. Introduction

Park SW, Baek AR, Lee HL, Jeong SW, Yang SH, Kim YH, Chung MP, on behalf of the Korean Interstitial Lung Diseases Study Group

Idiopathic interstitial pneumonia (IIP) is a histologically identifiable pulmonary disease without a known cause that usually infiltrates the lung interstitium. IIP is largely classified into idiopathic pulmonary fibrosis, idiopathic non-specific...
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Pathological interpretation of connective tissue disease-associated lung diseases

Kwon KY

Connective tissue diseases (CTDs) can affect all compartments of the lungs, including airways, alveoli, interstitium, vessels, and pleura. CTD-associated lung diseases (CTD-LDs) may present as diffuse lung disease or as...
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A review of current studies on cellular and molecular mechanisms underlying pulmonary fibrosis induced by chemicals

Kim HR, Shin DY, Chung KH

Several studies showed that the inflammatory and fibrotic responses induced by polyhexamethylene guanidine phosphate (PHMG-p) were similar to those observed for idiopathic pulmonary fibrosis in South Korea in 2011. “Omic”...
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Radiological Report of Pilot Study for the Korean Lung Cancer Screening (K-LUCAS) Project: Feasibility of Implementing Lung Imaging Reporting and Data System

Lee JW, Kim HY, Goo JM, Kim EY, Lee SJ, Kim TJ, Kim Y, Lim J

OBJECTIVE: To report the radiological results of a pilot study for the Korean Lung Cancer Screening project conducted to evaluate the feasibility of lung cancer screening using low-dose chest computed...
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Abnormal Bolus Reflux Is Associated With Poor Pulmonary Outcome in Patients With Idiopathic Pulmonary Fibrosis

Borges LF, Jagadeesan V, Goldberg H, Gavini S, Lo WK, Burakoff R, Feldman N, Chan WW

  • KMID: 2417383
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):395-402.
  • doi: 10.5056/jnm18023
BACKGROUND/AIMS: Gastroesophageal reflux (GER) is postulated to play a role in idiopathic pulmonary fibrosis (IPF). However, the value of objective GER measures in predicting IPF disease progression is unclear. We...
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Interstitial Lung Disease and Lung Cancer Development: A 5-Year Nationwide Population-Based Study

Choi WI, Park SH, Park BJ, Lee CW

PURPOSE: In this nationwide 5-year longitudinal population-based study, we aimed at investigating the incidence of lung cancer among patients with interstitial lung disease. MATERIALS AND METHODS: Data was collected from the...
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Pirfenidone-Induced Photosensitivity in a Patient with Idiopathic Pulmonary Fibrosis

Kim HJ, Seo JW, Kim TH, Choi SH, Song KH, Kim KH

No abstract available.
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Treatment of connective tissue disease-associated interstitial lung disease: the pulmonologist's point of view

Koo SM, Uh ST

Interstitial lung disease (ILD) occurs in 15% of patients with collagen vascular disease (CVD), referred to as connective tissue disease (CTD). Despite advances in management strategies, ILD continues to be...
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Obstructive Sleep Apnea in Interstitial Lung Disease

Kim SB, Lee SH, Kang HH

Obstructive sleep apnea is a common disorder in which respiratory flow decreases or disappears despite respiratory effort due to occlusion of the upper respiratory tract during sleep. Oxidative stress and...
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