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Analgesic Effect of Toll-like Receptor 4 Antagonistic Peptide 2 on Mechanical Allodynia Induced with Spinal Nerve Ligation in Rats

Yin Y, Park H, Lee SY, Lee WH, Song HJ, Kim J, Kim DW, Hong J

Neuroinflammation is one of the key mechanisms of neuropathic pain, which is primarily mediated by the Toll-like receptor 4 (TLR4) signaling pathways in microglia. Therefore, TLR4 may be a reasonable...
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Two Cases of Opioid-Induced Hyperalgesia in Cancer Patients Treated with Opioids for Pain Management

Hong S, Kwon JH, Han SJ

Opioids are important drugs for the management of severe cancer pain without a ceiling effect. However, opioid administration leads to dose-limiting complications including drowsiness, hallucinations, delirium, respiratory depression, cognitive impairment,...
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Effect of sec-O-glucosylhamaudol on mechanical allodynia in a rat model of postoperative pain

Koh GH, Song H, Kim SH, Yoon MH, Lim KJ, Oh SH, Jung KT

BACKGROUND: This study was performed in order to examine the effect of intrathecal sec-O-glucosylhamaudol (SOG), an extract from the root of the Peucedanum japonicum Thunb., on incisional pain in a...
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Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats

Yoon JH, Son JY, Kim MJ, Kang SH, Ju JS, Bae YC, Ahn DK

The aim of the present study was to examine the effects of preemptive analgesia on the development of trigeminal neuropathic pain. For this purpose, mechanical allodynia was evaluated in male...
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Cold Allodynia after C2 Root Resection in Sprague-Dawley Rats

Chung D, Cho DC, Park SH, Kim KT, Sung JK, Jeon Y

OBJECTIVE: The purpose of this study was to evaluate pain-related behaviors after bilateral C2 root resection and change in pain patterns in the suboccipital region in rats. METHODS: Male Sprague-Dawley rats...
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MicroRNA-200a Targets Cannabinoid Receptor 1 and Serotonin Transporter to Increase Visceral Hyperalgesia in Diarrhea-predominant Irritable Bowel Syndrome Rats

Hou Q, Huang Y, Zhang C, Zhu S, Li P, Chen X, Hou Z, Liu F

  • KMID: 2422855
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):656-668.
  • doi: 10.5056/jnm18037
BACKGROUND/AIMS: MicroRNAs (miRNAs) were reported to be responsible for intestinal permeability in diarrhea-predominant irritable bowel syndrome (IBS-D) rats in our previous study. However, whether and how miRNAs regulate visceral hypersensitivity...
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Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model

Fujita M, Fukuda T, Sato Y, Takasusuki T, Tanaka M

BACKGROUND: To identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the...
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Intravenous Administration of Substance P Attenuates Mechanical Allodynia Following Nerve Injury by Regulating Neuropathic Pain-Related Factors

Chung E, Yoon TG, Kim S, Kang M, Kim HJ, Son Y

This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI)...
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Peripheral Cellular Mechanisms of Artemin-induced Thermal Hyperalgesia in Rats

Kim HJ, Yang KY, Lee MK, Park MK, Son JY, Ju JS, Ahn DK

In the present study, we investigated the role of peripheral ionotropic receptors in artemin-induced thermal hyperalgesia in the orofacial area. Male Sprague-Dawley rats weighting 230 to 280 g were used...
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Participation of central GABAA receptors in the trigeminal processing of mechanical allodynia in rats

Kim MJ, Park YH, Yang KY, Ju JS, Bae YC, Han SK, Ahn DK

Here we investigated the central processing mechanisms of mechanical allodynia and found a direct excitatory link with low-threshold input to nociceptive neurons. Experiments were performed on male Sprague-Dawley rats weighing...
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Comparison of Mechanical Allodynia and Recovery of Locomotion and Bladder Function by Different Parameters of Low Thoracic Spinal Contusion Injury in Rats

Carter MW, Johnson KM, Lee JY, Hulsebosch CE, Gwak YS

BACKGROUND: The present study was designed to examine the functional recovery following spinal cord injury (SCI) by adjusting the parameters of impact force and dwell-time using the Infinite Horizon (IH)...
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The Synergistic Effect of Intrathecally Administered Dexmedetomidine and Ketorolac on Mechanical Allodynia in Rats with Spinal Nerve Ligation

Cheong YK, Kim YD, Lee JH, Ham HD, Choi SW, Park SJ

OBJECTIVES: This research was carried out to identify the synergistic effect of dexmedetomidine and ketorolac on neuropathic pain alleviation. METHODS: The anti-allodynic effect of intrathecal dexmedetomidine and ketorolac was investigated in...
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Reduction in mechanical allodynia in complex regional pain syndrome patients with ultrasound-guided pulsed radiofrequency treatment of the superficial peroneal nerve

Chae WS, Kim SH, Cho SH, Lee JH, Lee MS

The superficial peroneal nerve is vulnerable to damage from ankle sprain injuries and fractures as well as surgery to this region. And it is also one of the most commonly...
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Olanzapine Attenuates Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve Ligation

Fukuda T, Yamashita , Hisano S, Tanaka M

BACKGROUND: Neuropathic pain is a global clinical problem; nevertheless, nerve injury treatment methods remain limited. Olanzapine has antinociceptive and anti-nueropathic properties; however, its preventive effects have not been assessed in...
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Effect of intraoperative infusion of ketamine on remifentanil-induced hyperalgesia

Choi E, Lee H, Park HS, Lee GY, Kim YJ, Baik HJ

BACKGROUND: Opioid induced hyperalgesia (OIH) is related with high opioid dosage, a long duration of opioid administration, and abrupt discontinuation of infused opioids in anesthetic settings. Ketamine is known to...
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Role of Corticotropin-releasing Factor Signaling in Stress-related Alterations of Colonic Motility and Hyperalgesia

Tache Y, Million M

  • KMID: 2381228
  • J Neurogastroenterol Motil.
  • 2015 Jan;21(1):8-24.
  • doi: 10.5056/jnm14162
The corticotropin-releasing factor (CRF) signaling systems encompass CRF and the structurally related peptide urocortin (Ucn) 1, 2, and 3 along with 2 G-protein coupled receptors, CRF1 and CRF2. CRF binds...
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The effect of intrathecal curcumin on mechanical allodynia in rats after L5 spinal nerve ligation

Lee JH, Kim YD, Jung HC, Cheong YK

No abstract available.
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Opioid induced hyperalgesia in anesthetic settings

Lee HJ, Yeomans DC

Pain is difficult to investigate and difficult to treat, in part, because of problems in quantification and assessment. The use of opioids, combined with classic anesthetics to maintain hemodynamic stability...
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Interaction between postoperative shivering and hyperalgesia caused by high-dose remifentanil

Song YK, Lee C, Seo DH, Park SN, Moon SY, Park CH

BACKGROUND: High-dose remifentanil-based anesthesia is associated with opioid-induced hyperalgesia (OIH) and postanesthetic shivering (PAS). These effects can be prevented by N-methyl-d-aspartate (NMDA) receptor antagonists. This study aimed to investigate correlations...
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Opioid-induced hyperalgesia

Lee H

Perioperative opioid-induced hyperalgesia (OIH) can be defined as the "increased perception of pain after opioid-based anesthesia and surgery" since hyperalgesia is defined as "increased pain from a stimulus that normally...
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