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Dopaminergic Control of the Feeding Circuit

Baik JH

There is increasing evidence demonstrating that reward-related motivational food intake is closely connected with the brain’s homeostatic system of energy balance and that this interaction might be important in the...
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A Pilot Study on the Effect of Cannabis Extract on Weight Loss in Diet-induced Obese Mice

Jang YJ, Lim SW, Woo SY, Kim SY, Kim DK

Objectives This study aimed to investigate the pharmacological effect of cannabis extract on weight loss in diet-induced obese mice. Methods A total of 12 C57BL/6 male mice (Orient Bio), aged 6...
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The solution on enigmas in COVID-19: the protein-homeostasis-system hypothesis

Lee KY

Infectious diseases, including coronavirus disease 2019 (COVID-19), are representative, of which etiology is known in all human diseases. However, many enigmas persist in relation to COVID-19, including different clinical phenotypes...
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Immunopathogenesis of COVID-19 and early immunomodulators

Lee KY, Rhim JW, Kang JH

The novel coronavirus disease 2019 (COVID-19) is spreading globally. Although its etiologic agent is discovered as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there are many unsolved issues in COVID-19 and...
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Natural Products Targeting Wnt/β-catenin Signaling Pathway

Kim D, Lee SK

The canonical Wnt/β-catenin signaling pathways play an important role in the embryonic development, cell proliferation, differentiation, and adhesion. Therefore, the abnormal activation and repression have been associated with uncontrolled homeostasis...
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The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease

Kim HJ, Jung Y

Eosinophils are terminally differentiated cytotoxic effector cells that have a role in parasitic infections and allergy by releasing their granule-derived cytotoxic proteins. However, an increasing number of recent observations indicate...
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Three-Month Daily Consumption of Sugar-SweetenedBeverages Affects the Liver, Adipose Tissue, andGlucose Metabolism

Lee G, Han JH, Maeng HJ, Lim S

Background: Growing evidence suggests links between sugar-sweetened beverages (SSBs) and metabolicdisorders. We investigated the effects of SSBs commonly consumed by adolescents and their relationships toglucose metabolism and fatty liver. Methods: We...
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Dynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with urolithiasis

Sonmez MG, Kozanhan B, Deniz CD, Iyisoy MS, Kilinc MT, Ecer G, Ozturk A, Neselioglu S, Erel O

PURPOSE: A dynamic thiol/disulfide balance is pivotal in organizing anti-oxidant defense, detoxification, apoptosis, and enzyme activities, as well as transcription and cellular signal-transfer mechanisms. The connection between urolithiasis and oxidant/antioxidant...
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Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes

Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY

Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and...
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Mitochondrial Toxins and Healthy Lifestyle Meet at the Crossroad of Hormesis

Lee YM, Lee DH

Mitochondrial function is crucial for the maintenance of cellular homeostasis under physiological and stress conditions. Thus, chronic exposure to environmental chemicals that affect mitochondrial function can have harmful effects on...
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T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response

Kwon SH, Seo EB, Lee SH, Cho CH, Kim SJ, Kim SJ, Kim HR, Ye SK

Signal transducer and activator of transcription 3 (STAT3) has a crucial role in various autoimmune disorders including, inflammatory bowel disease (IBD). Our previous study demonstrated that STAT3 activation by IL-6...
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The Cut-off Values of Surrogate Measures for Insulin Sensitivity in a Healthy Population in Korea according to the Korean National Health and Nutrition Examination Survey (KNHANES) 2007–2010

Moon S, Park JH, Jang EJ, Park YK, Yu JM, Park JS, Ahn Y, Choi SH, Yoo HJ

BACKGROUND: This study aimed to identify the gender-specific characteristics of the surrogate measures of insulin resistance and to establish valid cut-off values for metabolic abnormalities in a representative sample in...
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The Different Expression Patterns of HSP22, a Late Embryogenesis Abundant-like Protein, in Hypertrophic H9C2 Cells Induced by NaCl and Angiotensin II

Sung JH, Song A, Park T, Kim E, Lee S

BACKGROUND: High-NaCl diet is a contributing factor for cardiac hypertrophy. The role of HSP22 as a protective protein during cardiac hypertrophy due to hypernatremia is unclear. Accordingly, this study aimed...
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Association of Serum Vitamin D with Insulin Resistance and Beta Cell Function in Korean Health Checkup Examinees

Kim HS, Ryu SY, Park J, Han MA, Choi SW, Shin MH

OBJECTIVES: This study was conducted to examine the association of serum Vitamin D with insulin resistance and β-cell function in Korean health checkup examinees. METHODS: This study subjects were 374 healthy...
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Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders

Kano M, Dupont P, Aziz Q, Fukudo S

  • KMID: 2422842
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):512-527.
  • doi: 10.5056/jnm18072
This review provides a comprehensive overview of brain imaging studies of the brain-gut interaction in functional gastrointestinal disorders (FGIDs). Functional neuroimaging studies during gut stimulation have shown enhanced brain responses...
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Sleep Disturbances as a Risk Factor for Stroke

Koo DL, Nam H, Thomas RJ, Yun CH

Sleep, a vital process of human being, is carefully orchestrated by the brain and consists of cyclic transitions between rapid eye movement (REM) and non-REM (NREM) sleep. Autonomic tranquility during...
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Targeting Glutamine Metabolism for Cancer Treatment

Choi YK, Park KG

Rapidly proliferating cancer cells require energy and cellular building blocks for their growth and ability to maintain redox balance. Many studies have focused on understanding how cancer cells adapt their...
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Mast Cells and Microbiome in Skin Immunity

Park M, Cho KA

The skin functions as a physical barrier against entry of pathogens while concomitantly supporting a myriad of commensal organisms. The characterization of these microbial communities has enhanced our knowledge of...
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Intermuscular Adipose Tissue Content and Intramyocellular Lipid Fatty Acid Saturation Are Associated with Glucose Homeostasis in Middle-Aged and Older Adults

Kim JE, Dunville K, Li J, Cheng JX, Conley TB, Couture CS, Campbell W

BACKGROUND: Insulin resistance is associated with the higher content of intermuscular adipose tissue (IMAT) and the saturation of intramyocellular lipid (IMCL), but a paucity of data exist in humans. This...
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The Effect of Pravastatin on Insulin Resistance in Hyperglycemic Patients

Jeong YJ, Kim JM, Jang SJ, Bang JH, Jung YG, Kim ST, Kang SH, Choi JI, Kim SS, Kang MY

BACKGROUND: The effect of pravastatin on insulin resistance (IR) is controversial and poorly studied in prediabetes. METHODS: This study was performed in hyperglycemic patients at Saint Carollo Hospital from January 1,...
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