- Links between Serine Biosynthesis Pathway and Epigenetics in Cancer Metabolism
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Kim H, Park YJ
- KMID: 2417711
- Clin Nutr Res.
- 2018 Jul;7(3):153-160.
- doi: 10.7762/cnr.2018.7.3.153
Cancer metabolism is considered as one of major cancer hallmarks. It is important to understand cancer-specific metabolic changes and its impact on cancer biology to identify therapeutic potentials. Among cancer-specific... -
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- Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies
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di Luccio
- KMID: 2171336
- J Cancer Prev.
- 2015 Jun;20(2):113-120.
- doi: 10.15430/JCP.2015.20.2.113
BACKGROUND: Multiple myeloma SET domain (MMSET)/nuclear receptor binding SET domain 2 (NSD2) is a lysine histone methyltransferase (HMTase) and bona fide oncoprotein found aberrantly expressed in several cancers, suggesting potential... -
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- Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers
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Kondo Y
- KMID: 1758603
- Yonsei Med J.
- 2009 Aug;50(4):455-463.
- doi: 10.3349/ymj.2009.50.4.455
DNA methylation, histone modifications, and the chromatin structure are profoundly altered in human cancers. The silencing of cancer-related genes by these epigenetic regulators is recognized as a key mechanism in... -
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- A Rare Case of Pediatric T Lymphoblastic Leukemia With t(11;17)(q23;q21) Involving Mixed-Lineage Leukemia Gene Rearrangement
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Kim H, Lee JK, Lee JA, Hong YJ, Hong SI, Jo HS, Chang YH
- KMID: 2373500
- Ann Lab Med.
- 2016 Jan;36(1):64-66.
- doi: 10.3343/alm.2016.36.1.64
No abstract available. -
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- Increased lysine N-methylation of a 23-kDa protein during hepatic regeneration
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Choi YB, Ko MH, Shin CH, Kim KS, Hong KM, Paik MK, Park DE
- KMID: 1056226
- Exp Mol Med.
- 2005 Jun;37(3):155-160.
The methylation of a 23-kDa nuclear protein increased after partial hepatectomy and methylation returned to basal levels after the initial stage of regeneration. The methylating enzyme was partially purified from... -
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- Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
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Yoon KA, Woo SM, Kim YH, Kong SY, Lee MK, Han SS, Kim TH, Lee WJ, Park SJ
- KMID: 2464315
- Gut Liver.
- 2019 Nov;13(6):683-689.
- doi: 10.5009/gnl18355
BACKGROUND/AIMS: Pancreatic ductal adenocarcinoma (PDA) is associated with an extremely poor prognosis. This study assessed the genetic diversity among patients with PDA and compared their mutational profiles before and after... -
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- MLL-SEPT5 Fusion Transcript in Two de novo Acute Myeloid Leukemia Patients With t(11;22)(q23;q11)
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Wang N, Wu X, Sheng G, Ma L, Wen L, Yao H, Chen S
- KMID: 2373585
- Ann Lab Med.
- 2016 Sep;36(5):501-503.
- doi: 10.3343/alm.2016.36.5.501
No abstract available. -
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- Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
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Wang SE, Ko SY, Jo S, Jo HR, Han J, Kim YS, Son H
- KMID: 2458551
- Exp Neurobiol.
- 2019 Aug;28(4):537-546.
- doi: 10.5607/en.2019.28.4.537
Silent information regulator 2 (Sirtuin2 / SIRT2) is a NADâº-dependent deacetylase that regulates the cellular oxidative stress response. It modulates transcriptional silencing and protein stability through deacetylation of target proteins... -
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- Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma
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Lee SH, Lee EH, Lee SH, Lee YM, Kim HD, Kim YZ
- KMID: 2164512
- J Korean Med Sci.
- 2015 Aug;30(8):1157-1166.
- doi: 10.3346/jkms.2015.30.8.1157
Alteration of apoptosis is related with progression and recurrence of atypical meningiomas (AMs). However, no comprehensive study has been conducted regarding histone modification regulating apoptosis in AMs. This study aimed... -
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- Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A
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Tran HT, Kim HN, Lee IK, Nguyen-Pham TN, Ahn JS, Kim YK, Lee JJ, Park KS, Kook H, Kim HJ
- KMID: 1429188
- J Korean Med Sci.
- 2013 Feb;28(2):237-246.
- doi: 10.3346/jkms.2013.28.2.237
SUV39H1 is a histone 3 lysine 9 (H3K9)-specific methyltransferase that is important for heterochromatin formation and the regulation of gene expression. Chaetocin specifically inhibits SUV39H1, resulted in H3K9 methylation reduction... -
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- Acute Myeloid Leukemia With MLL Rearrangement and CD4+/CD56+ Expression can be Misdiagnosed as Blastic Plasmacytoid Dendritic Cell Neoplasm: Two Case Reports
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Lee JM, Kim IS, Lee JN, Park SH, Kim HH, Chang CL, Lee EY, Kim HR, Oh SH, Song SA
- KMID: 2373582
- Ann Lab Med.
- 2016 Sep;36(5):494-497.
- doi: 10.3343/alm.2016.36.5.494
No abstract available. -
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- The functional role of the CARM1-SNF5 complex and its associated HMT activity in transcriptional activation by thyroid hormone receptor
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Choi HK, Choi KC, Oh SY, Kang HB, Lee YH, Haam S, Ahn YH, Kim KS, Kim K, Yoon HG
- KMID: 756078
- Exp Mol Med.
- 2007 Aug;39(4):544-555.
We have investigated the function and mechanisms of the CARM1-SNF5 complex in T3-dependent transcriptional activation. Using specific small interfering RNAs (siRNA) to knock down coactivators in HeLa alpha2 cells, we... -
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- Clathrin Assembly Lymphoid Myeloid Leukemia-AF10-positive Acute Leukemias: A Report of 2 Cases with a Review of the Literature
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Huh JY, Chung S, Oh D, Kang MS, Eom HS, Cho EH, Han MH, Kong SY
- KMID: 1096795
- Korean J Lab Med.
- 2010 Apr;30(2):117-121.
- doi: 10.3343/kjlm.2010.30.2.117
The translocation t(10;11)(p13;q14q21) has been found to be recurrent in acute lymphoblastic and myeloid leukemias, and results in the fusion of the clathrin assembly lymphoid myeloid leukemia (CALM) gene with... -
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