- Dissection of Cellular Communication between Human Primary Osteoblasts and Bone Marrow Mesenchymal Stem Cells in Osteoarthritis at Single-Cell Resolution
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Liu Y, Chen Y, Li XH, Cao C, Zhang HX, Zhou C, Chen Y, Gong Y, Yang JX, Cheng L, Chen XD, Shen H, Xiao HM, Tan LJ, Deng HW
- KMID: 2545233
- Int J Stem Cells.
- 2023 Aug;16(3):342-355.
- doi: 10.15283/ijsc22101
Background and Objectives: Osteoblasts are derived from bone marrow mesenchymal stem cells (BMMSCs) and play important role in bone remodeling. While our previous studies have investigated the cell subtypes and heterogeneity... -
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- Genetic heterogeneity of liver cancer stem cells
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Kim M, Jo KW, Kim H, Han ME, Oh SO
- KMID: 2540989
- Anat Cell Biol.
- 2023 Mar;56(1):94-108.
- doi: 10.5115/acb.22.161
Cancer cell heterogeneity is a serious problem in the control of tumor progression because it can cause chemoresistance and metastasis. Heterogeneity can be generated by various mechanisms, including genetic evolution... -
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- Shaping Heterogeneity of Naive CD8+ T Cell Pools
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Lee SW, Lee GW, Kim HO, Cho JH
- KMID: 2544657
- Immune Netw.
- 2023 Feb;23(1):e2.
- doi: 10.4110/in.2023.23.e2
Immune diversification helps protect the host against a myriad of pathogens. CD8+ T cells are essential adaptive immune cells that inhibit the spread of pathogens by inducing apoptosis in infected... -
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- Clinical and molecular characteristics of Korean children with Cornelia de Lange syndrome
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Kang D, Kim HY, Chae JH, Ko JM
- KMID: 2537690
- J Genet Med.
- 2022 Dec;19(2):85-93.
- doi: 10.5734/JGM.2022.19.2.85
Purpose: Cornelia de Lange syndrome (CdLS) is a rare genetically heterogeneous disorder caused by genetic variants of the cohesin complex. However, the diverse genetic etiologies and their phenotypic correlations in... -
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- Beta-Meta: a meta-analysis application considering heterogeneity among genome-wide association studies
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Kim G, Lee Y, Park JH, Kim D, Lee W
- KMID: 2540177
- Genomics Inform.
- 2022 Dec;20(4):e49.
- doi: 10.5808/gi.22046
Many packages for a meta-analysis of genome-wide association studies (GWAS) have beendeveloped to discover genetic variants. Although variations across studies must be considered, there are not many currently-accessible packages that... -
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- Homogenic Evaluation for Spatial Distribution in Osteoclast Differentiation
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Lim HS, Shin HI, Jeong D
- KMID: 2536848
- J Bone Metab.
- 2022 Nov;29(4):265-269.
- doi: 10.11005/jbm.2022.29.4.265
Background: Cells have heterogeneous cellular diversity in size, morphology, cell cycle, metabolism, differentiation degree, and spatial distribution. The shift of specific cells towards the desired cells is crucial for maintaining... -
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- Demographic and diagnostic markers in new onset pediatric type 1 and type 2 diabetes: differences and overlaps
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Nieto T, Castillo B, Nieto J, Redondo MJ
- KMID: 2531276
- Ann Pediatr Endocrinol Metab.
- 2022 Jun;27(2):121-125.
- doi: 10.6065/apem.2142170.085
Purpose: Type 1 diabetes (T1D) is the most common type of diabetes in children, but the frequency of type 2 diabetes (T2D) is increasing rapidly. Classification of diabetes is based... -
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- Single-Cell RNA Sequencing of Bone Marrow Mesenchymal Stem Cells from the Elderly People
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Zhu D, Gao J, Tang C, Xu Z, Sun T
- KMID: 2529789
- Int J Stem Cells.
- 2022 May;15(2):173-182.
- doi: 10.15283/ijsc21042
Background and Objectives: Bone marrow mesenchymal stem cells (BMSCs) show considerable promise in regenerative medicine. Many studies demonstrated that BMSCs cultured in vitro were highly heterogeneous and composed of diverse... -
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- Experimental development of the epigenomic library construction method to elucidate the epigenetic diversity and causal relationship between epigenome and transcriptome at a single-cell level
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Park K, Jeon MC, Kim B, Cha B, Kim JI
- KMID: 2527945
- Genomics Inform.
- 2022 Mar;20(1):e2.
- doi: 10.5808/gi.21078
The method of single-cell RNA sequencing has been rapidly developed, and numerous experiments have been conducted over the past decade. Their results allow us to recognize various subpopulations and rare... -
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- Utility of Next-Generation Sequencing for Deciphering Intratumor Heterogeneity in Prostate Cancer
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Joung JG, Park JY, Yang SY, Jeong J
- KMID: 2516482
- Korean J Urol Oncol.
- 2021 May;19(2):101-108.
- doi: 10.22465/kjuo.2021.19.2.101
Prostate cancer has long been considered a disease with a heterogeneous phenotype. The intratumor heterogeneity (ITH) may affect diverse phenotypes such as treatment response, drug resistance, and overall clinical outcomes.... -
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- A Large-Scale, Stratified Genetic Analysis of the Major Histocompatibility Complex Region in Early- and LateOnset Psoriasis in China
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Zhou Y, Cai M, Sheng Y, Zhang X
- KMID: 2510157
- Ann Dermatol.
- 2021 Feb;33(1):61-67.
- doi: 10.5021/ad.2021.33.1.61
Background: Psoriasis vulgaris is a chronic inflammatory skin disease which occur at any age. It can be clinically classified into two age-onset subtypes: early-onset psoriasis (EOP;＜40 years) and late-onset psoriasis... -
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- Patient-derived xenografts as compatible models for precision oncology
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Cho SY
- KMID: 2506037
- Lab Anim Res.
- 2020 Jun;36(2):108-118.
- doi: 10.1186/s42826-020-00045-1
Cancer is a very heterogeneous disease, displaying heterogeneity between patients (inter-tumoral heterogeneity) and heterogeneity within a patient (intra-tumoral heterogeneity). Precision oncology is a diagnostic and therapeutic approach for cancers based... -
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- Functional Connectivity of the Striatum as a Neural Correlate of Symptom Severity in Patient with Obsessive-Compulsive Disorder
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Park J, Kim T, Kim M, Lee TY, Kwon JS
- KMID: 2501483
- Psychiatry Investig.
- 2020 Feb;17(2):87-95.
- doi: 10.30773/pi.2019.0206
Objective It is well established that the cortico-striato-thalamo-cortical (CSTC) circuit is implicated in the pathophysiology of obsessive- compulsive disorder (OCD). However, reports on corticostriatal functional connectivity (FC) in OCD have... -
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- HER2 status in breast cancer: changes in guidelines and complicating factors for interpretation
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Ahn S, Woo JW, Lee K, Park SY
- KMID: 2501593
- J Pathol Transl Med.
- 2020 Jan;54(1):34-44.
- doi: 10.4132/jptm.2019.11.03
Human epidermal growth factor receptor 2 (HER2) protein overexpression and/or HER2 gene amplification is found in about 20% of invasive breast cancers. It is a sole predictive marker for treatment... -
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- Bile Acid Transporters Are Expressed and Heterogeneously Distributed in Rat Bile Ducts
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Luo ZL, Cheng L, Wang T, Tang LJ, Tian FZ, Xiang K, Cui L
- KMID: 2458514
- Gut Liver.
- 2019 Sep;13(5):569-575.
- doi: 10.5009/gnl18265
BACKGROUND/AIMS: Cholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile... -
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- Vascular Anomaly: An Updated Review
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Park M
- KMID: 2449226
- Clin Pediatr Hematol Oncol.
- 2019 Apr;26(1):6-11.
- doi: 10.15264/cpho.2019.26.1.6
Vascular anomalies comprise a heterogeneous group of disorders characterized by abnormal growth or development of blood vessels. Diagnosis of vascular anomalies is often challenging due to the large variety of... -
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- Identification of ERBB Pathway-Activated Cells in Triple-Negative Breast Cancer
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Cho SY
- KMID: 2447793
- Genomics Inform.
- 2019 Mar;17(1):e3.
- doi: 10.5808/GI.2019.17.1.e3
Intratumor heterogeneity within a single tumor mass is one of the hallmarks of malignancy and has been reported in various tumor types. The molecular characterization of intratumor heterogeneity in breast... -
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- Evaluation and Interpretation of Transcriptome Data Underlying Heterogeneous Chronic Obstructive Pulmonary Disease
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Ham S, Oh YM, Roh TY
- KMID: 2447792
- Genomics Inform.
- 2019 Mar;17(1):e2.
- doi: 10.5808/GI.2019.17.1.e2
Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease, featured by airflow obstruction. Recently, a comprehensive analysis of the transcriptome in lung tissue of COPD patients was... -
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- Radiomics in Oncological PET/CT: a Methodological Overview
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Ha S, Choi H, Paeng JC, Cheon GJ
- KMID: 2446879
- Nucl Med Mol Imaging.
- 2019 Feb;53(1):14-29.
- doi: 10.1007/s13139-019-00571-4
Radiomics is a medical imaging analysis approach based on computer-vision. Metabolic radiomics in particular analyses the spatial distribution patterns of molecular metabolism on PET images. Measuring intratumoral heterogeneity via image... -
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- Intervention meta-analysis: application and practice using R software
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Shim SR, Kim SJ
- KMID: 2469411
- Epidemiol Health.
- 2019;41:e2019008.
- doi: 10.4178/epih.e2019008
The objective of this study was to describe general approaches for intervention meta-analysis available for quantitative data synthesis using the R software. We conducted an intervention meta-analysis using two types... -
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