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Epidemiological Aspects of Hepatitis E Virus Infections between South Korea and Japan

Lee MJ, Lee WC, Kwon YH

Purpose: Hepatitis E outbreaks are a serious public health concern in the world. The pilots or air traffic controllers can be incapacitated by severe hepatitis symptoms. If the symptoms of...
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Construction of an avian hepatitis E virus replicon expressing heterologous genes and evaluation of its potential as an RNA vaccine platform

Moon HW, Sung HW, Park J, Kwon HM

To evaluate avian hepatitis E virus (aHEV) as an RNA vaccine platform, open reading frame 2 (ORF2) of aHEV was replaced by heterologous genes, such as enhanced green fluorescent protein...
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Detection and genetic analysis of zoonotic hepatitis E virus, rotavirus, and sapovirus in pigs

Lyoo EL, Park BJ, Ahn HS, Han SH, Go HJ, Kim DH, Lee JB, Park SY, Song CS, Lee SW, Choi IS

The zoonotic transmission of viral diseases to humans is a serious public health concern. Pigs are frequently a major reservoir for several zoonotic viral diseases. Therefore, periodic surveillance is needed...
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Hepatic Failure Due to Hepatitis E Virus Infection in a Patient with Necrotic Hepatocellular Carcinoma

Kim JH, Doh YS, Jang JW, Kang MS, Kim NM, Kim SH, Baek IH, Jung SH

In patients with hepatocellular carcinoma (HCC) or liver cirrhosis (LC) accompanied by hepatitis E virus (HEV) infection, hepatic failure often leads to debility. Here, we report about a 63-year-old man...
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Detection and characterization of avian hepatitis E virus from broiler breeders and layers in Korea

Moon HW, Sung HW, Kwon HM

The helicase genes and hypervariable regions (HVRs) of three avian hepatitis E viruses (HEVs) detected at three different farms were sequenced and characterized. Two isolates (DW-L and GI-B2) were classified...
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Detection of hepatitis E virus genotypes 3 and 4 in pig farms in Korea

Kim YH, Park BJ, Ahn HS, Han SH, Go HJ, Kim DH, Lee JB, Park SY, Song CS, Lee SW, Choi IS

Zoonotic transmission of hepatitis E virus (HEV) is mostly mediated by HEV-3 and HEV-4 genotypes, and domestic pigs are an important reservoir of these genotypes. A survey of 14 pig...
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Detection of Serum Antibodies to Hepatitis E Virus Based on HEV Genotype 3 ORF2 Capsid Protein Expressed in Nicotiana benthamiana

Mazalovska M, Varadinov , Koynarski , Minkov I, Teoharov P, Lomonossoff GP, Zahmanova

BACKGROUND: Hepatitis E virus (HEV) causes epidemics in developing countries and is primarily transmitted through the fecal-oral route. There have been recent reports on the zoonotic spread of the virus,...
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Hepatitis E virus as an emerging zoonotic pathogen

Park WJ, Park BJ, Ahn HS, Lee JB, Park SY, Song CS, Lee SW, Yoo HS, Choi IS

Hepatitis E outbreaks are a serious public health concern in developing countries. The disease causes acute infections, primarily in young adults. The mortality rate is approximately 2%; however, it can...
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Induction of antibody and interferon-gamma production in mice immunized with virus-like particles of swine hepatitis E virus

Song YJ, Park WJ, Lee SK, Lee JB, Park SY, Song CS, Lee SW, Seo KH, Kang YS, Song JY, Choi IS

Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers...
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Development of Enzyme-Linked Immunosorbent Assays Using 2 Truncated ORF2 Proteins for Detection of IgG Antibodies Against Hepatitis E Virus

Taherkhani R, Makvandi M, Farshadpour F

BACKGROUND: Without appropriate culture systems for hepatitis E virus (HEV), sufficient natural viral proteins are difficult to generate for use in serological tests. Therefore, it is important to produce large...
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Hepatitis E virus infections in humans and animals

Song YJ, Park WJ, Park BJ, Lee JB, Park SY, Song CS, Lee NH, Seo KH, Kang YS, Choi IS

Hepatitis E has traditionally been considered an endemic disease of developing countries. It generally spreads through contaminated water. However, seroprevalence studies have shown that hepatitis E virus (HEV) infections are...
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Development of a novel enzyme-linked immunosorbent assay to detect anti-IgG against swine hepatitis E virus

Lee WJ, Shin MK, Cha SB, Yoo HS

Swine hepatitis E virus (HEV) is widespread throughout pigs in both developing and industrialized countries. This virus is an important zoonotic agent and a public concern worldwide. Infected pigs are...
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Seroprevalence of hepatitis E virus in zoo animal species in Korea

Song YJ, Kim BS, Park WJ, Park BJ, Lee SK, Shin JI, Lee NH, Lee JB, Park SY, Song CS, Seo KH, Choi IS

  • KMID: 1991796
  • Korean J Vet Res.
  • 2013 Mar;53(1):65-68.
Hepatitis E virus (HEV) can infect not only human but also several animals. This study has been conducted to evaluate the comprehensive anti-HEV seroprevalence in zoo animals in Korea. Anti-HEV...
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Prevention of Viral Hepatitis and Vaccination

Cho YK, Song BC

  • KMID: 2263635
  • Korean J Med.
  • 2012 Feb;82(2):123-133.
Hepatitis viruses are most important cause of acute and chronic hepatitis. In past, hepatitis B virus was one of the major causes of acute hepatitis. Recently, around 60-70% of acute...
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Current Status of Hepatitis E Virus Infection in Korea

Jeong SH

  • KMID: 2284231
  • Gut Liver.
  • 2011 Dec;5(4):427-431.
Hepatitis E virus (HEV) is an emerging pathogen associated with acute viral hepatitis, and HEV is becoming increasingly recognized. Approximately 2% of acute viral hepatitis is caused by HEV, and...
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Seroprevalence of Hepatitis A and E Viruses Based on the Third Korea National Health and Nutrition Survey in Korea

Yun H, Lee HJ, Cheon D, Chu C, Oh KW, Kim YT, Jee Y

Objectives The purpose of this study was to investigate the seroprevalence of hepatitis A virus (HAV) and hepatitis E virus (HEV) in Korea during 2005. Methods Study subjects were selected from across Korea...
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A Case of Coinfection of Hepatitis A and E Virus with Hepatic Encephalopathy

Park JH, Kim BS, Lee CH, Kim SY, Seo JH, Hur CJ

  • KMID: 2258869
  • Korean J Med.
  • 2011 Jun;80(Suppl 2):S101-S105.
With recent hygienic improvements in Korea, the occurrence of overt acute viral hepatitis A in adults is increasing. Acute viral hepatitis E, which has seldom been reported, has also been...
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Detection of swine hepatitis E virus in the porcine hepatic lesion in Jeju Island

Lee SH, Kang SC, Kim DY, Bae JH, Kim JH

Swine hepatitis E virus (HEV) is an emerging zoonotic pathogen due to its close genomic similarity to human HEV. The prevalence of swine HEV in the hepatic lesion of pigs...
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Nine Cases of Sporadic Acute Hepatitis E in Korea

Lim JW, Park CS, Ahn JM, Yu MH, Kim TS, Lim YS, Chung SW, Kim GM, Chung YH, Lee YS, Suh DJ

  • KMID: 760650
  • Korean J Hepatol.
  • 2006 Jun;12(2):230-236.
Hepatitis E virus is an enterically transmitted virus that causes endemic cases of acute hepatitis in many countries in Africa, and Southeast and Central Asia. Sporadic cases of acute hepatitis...
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Detection and Genetic Characterization of Isolates of Hepatitis E Virus from Pigs and Human in Chungnam Region of Korea

Chae MK, Kim JY, Chu J, Kim DH, Yoo HS, Park CS, Kim MC, Ju MH

Swine hepatitis E virus (HEV) has been reported as a new zoonotic agent due to its close genomic resemblance to the human HEV. Recently this virus is indicated as one...
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