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Expression of hepatitis C virus nonstructural 4B in transgenic mice

Wang AG, Moon HB, Kim JM, Hwang SB, Yu DY, Lee DS

  • KMID: 1094149
  • Exp Mol Med.
  • 2006 Jun;38(3):241-246.
Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated...
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KASL clinical practice guidelines: management of hepatitis C

The Korean Association for the Study of the Liver (KASL)

No abstract available.
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KASL clinical practice guidelines: Management of Hepatitis C

The Korean Association for the Study of the Liver (KASL)

No abstract available.
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Treatment of Chronic Hepatitis C: Shorter Treatment Duration for Genotype 2 or 3 Infection

Jeong SH

No abstract available.
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The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean

Kim JS, Ahn SM, Jung YK, Kwon OS, Kim YS, Choi DJ, Kim JH

Two variants of the inosine triphosphatase (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in...
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Hepatitis C virus and hepatocarcinogenesis

Jeong SW, Jang JY, Chung RT

Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The...
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Occult Hepatitis B Virus Infection in Chronic Hepatitis C

Jang JY, Park EJ

Occult HBV infection is defined as the presence of HBV DNA in the liver (with or without detectable or undetectable HBV DNA in the serum) of individuals testing negative for...
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Comparison of therapeutic results between combination therapy of peginterferon alpha-2a plus ribavirin and interferon alpha-2b plus ribavirin according to treatment duration in patients with chronic hepatitis C

Lee HJ, Eun JR, Choi JW, Kim KO, Moon HJ

BACKGROUND/AIMS: This study compared the efficacy and safety of combined peginterferon alfa (PEG-IFN) and ribavirin with that of combined interferon alpha (IFN-alpha) and ribavirin, according to the treatment duration...
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Hepatitis C virus-induced hepatocellular carcinoma

Goossens N, Hoshida Y

Hepatitis C virus (HCV) is a leading etiology of hepatocellular carcinoma (HCC). The interaction of HCV with its human host is complex and multilayered; stemming in part from the fact...
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A Polymorphism in the Microsomal Triglyceride Transfer Protein Can Predict the Response to Antiviral Therapy in Egyptian Patients with Chronic Hepatitis C Virus Genotype 4 Infection

Saad Y, Shaker O, Nassar Y, Ahmad L, Said M, Esmat G

BACKGROUND/AIMS: A polymorphism in the microsomal triglyceride transfer protein (MTP) is associated with hepatic fibrosis, and carriers showed higher levels of steatosis, higher levels of hepatitis C virus (HCV) RNA...
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New Therapeutic Agent for Chronic Hepatitis C: Direct Acting Agent

Chae HB

Peg-interferon and ribavirin has been the standard therapy of chronic hepatitis C for the past 15 years in Korea. However, the treatment paradigm is changing. Direct acting agents (DAAs) are...
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Current Status and Clinical Course of Hepatitis C Virus in Korea

Kwon JH, Bae SH

  • KMID: 1767540
  • Korean J Gastroenterol.
  • 2008 Jun;51(6):360-367.
The mortality due to chronic liver disease, including liver cirrhosis and hepatocellular carcinoma (HCC), ranks as one of the highest in Korea. The prevalence rates of hepatitis C virus (HCV)...
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Current status of liver disease in Korea: Hepatitis C

Lim YS

Chronic hepatitis C (CHC) is the third most common cause of chronic liver disease and hepatocellular carcinoma (HCC) in Korea, following hepatitis B virus (HBV) infection and alcohol. HCV prevalence...
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Advanced fibrosis is not a negative pretreatment predictive factor for genotype 2 or 3 chronic hepatitis C patients

Lee HS, Kweon YO, Tak WY, Park SY, Kang EJ, Lee YL, Yang HM, Park HW

BACKGROUND/AIMS: Chronic hepatitis C patients with advanced fibrosis have unsatisfactory sustained virological response (SVR) rates. Few data demonstrating the efficacy of combination therapy in chronic hepatitis C patients with advanced...
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Phospholipase D activity is elevated in hepatitis C virus core protein-transformed NIH3T3 mouse fibroblast cells

Kim J, Choi BH, Jang KL, Min DS

  • KMID: 1123766
  • Exp Mol Med.
  • 2004 Oct;36(5):454-460.
Hepatitis C Virus (HCV) is associated with a severe liver disease and increased frequency in the development of hepatocellular carcinoma. Overexpression of HCV core protein is known to transform fibroblast...
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A case: control study on the risk factors of hepatitis C virus infection among Koreans

Kim YS, Ahn YO, Kim DW

In order to identify the risk factors for hepatitis C virus (HCV) infections, a case-control study was conducted from September 1993 to April 1994. HCV infection was confirmed by the...
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Hepatitis C virus: virology and life cycle

Kim CW, Chang KM

Hepatitis C virus (HCV) is a positive sense, single-stranded RNA virus in the Flaviviridae family. It causes acute hepatitis with a high propensity for chronic infection. Chronic HCV infection can...
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Management of direct antiviral agent failures

Buti M, Esteban R

The current standard of care for patients with chronic hepatitis C virus (HCV) infection is a combination of direct-acting antiviral agents (DAAs). Most HCV patients treated with these drugs achieve...
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High effectiveness of peginterferon alfa-2a plus ribavirin therapy in Korean patients with chronic hepatitis C in clinical practice

Heo NY, Lim YS, Lee HC, Lee YS, Kim KM, Byun KS, Han KH, Lee KS, Paik SW, Yoon SK, Suh DJ

BACKGROUND/AIMS: Identifying the impact of a patient's ethnicity on treatment responses in clinical practice may assist in providing individualized treatment regimens for chronic hepatitis C (CHC). The effectiveness of standard...
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Evaluation of ARCHITECT HCV Core Antigen Assay

Song D, Kang JE, Kim SY, Hwang SH, Kim HH, Lee EY, Son HC

BACKGROUND: Hepatitis C virus (HCV) core antigen (Ag) levels are known to be well correlating with HCV RNA levels, and may be used as an alternative marker of HCV replication...
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