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Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells

Chung S, Hwang JT, Park JH, Choi HK

BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease triggered by epigenetic alterations, including lysine acetylation at histone or non-histone proteins, affecting the stability or transcription of lipogenic...
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Emodin exerts protective effect against palmitic acid-induced endoplasmic reticulum stress in HepG2 cells

Thomas SS, Park S, Cha YS, Kim KA

PURPOSE: Protein overloading in the endoplasmic reticulum (ER) leads to endoplasmic reticulum stress, which exacerbates various disease conditions. Emodin, an anthraquinone compound, is known to have several health benefits. The...
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Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver

Cho KW, Cho DH

BACKGROUND: Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in...
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A Compound Mutation (c.953C < G and c.49G < A) Aggravates Functional Impairments of C1-INH in Hep G2 Cells

Xu YY, Zhi YX

No abstract available.
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Picroside II attenuates fatty acid accumulation in HepG2 cells via modulation of fatty acid uptake and synthesis

Dhami-Shah H, Vaidya R, Udipi S, Raghavan S, Abhijit S, Mohan V, Balasubramanyam M, Vaidya A

BACKGROUND/AIMS: Hepatic steatosis is caused by an imbalance between free fatty acids (FFAs) uptake, utilization, storage, and disposal. Understanding the molecular mechanisms involved in FFAs accumulation and its modulation could...
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Increased glucose metabolism and alpha-glucosidase inhibition in Cordyceps militaris water extract-treated HepG2 cells

Kim DJ, Kang YH, Kim KK, Kim TW, Park JB, Choe M

BACKGROUND/OBJECTIVES: Recent living condition improvements, changes in dietary habits, and reductions in physical activity are contributing to an increase in metabolic syndrome symptoms including diabetes and obesity. Through such societal...
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The p90rsk-mediated signaling of ethanol-induced cell proliferation in HepG2 cell line

Kim HS, Kim SJ, Bae J, Wang Y, Park SY, Min YS, Je HD, Sohn UD

Ribosomal S6 kinase is a family of serine/threonine protein kinases involved in the regulation of cell viability. There are two subfamilies of ribosomal s6 kinase, (p90rsk, p70rsk). Especially, p90rsk is...
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Confirmation of HIF-1α Independent Pathway in the Progression of HepG2 Cells by Hypoxic Condition

Lee SW, Chong JU, Min SO, Kim KS

BACKGROUND/AIMS: When hepatocellular carcinoma (HCC) is exposed to hypoxic condition, HIF-1α is activated and results in angiogenesis and increased tumor burden. Although inhibition of HIF-1α may reduce tumor growth, there...
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Anti-cancer Activity of Osmanthus matsumuranus Extract by Inducing G2/M Arrest and Apoptosis in Human Hepatocellular Carcinoma Hep G2 Cells

Jin S, Park HJ, Oh YN, Kwon HJ, Kim JH, Choi YH, Kim BW

BACKGROUND: Osmanthus matsumuranus, a species of Oleaceae, is found in East Asia and Southeast Asia. The bioactivities of O. matsumuranus have not yet been fully understood. Here, we studied on...
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Anti-oxidant and Hepatoprotective Effect of White Ginsengs in H2O2-Treated HepG2 Cells

Parthasarathi S, Hong SC, Oh MH, Park YS, Yoo JH, Seol SY, Lee H, Park JD, Pyo MK

The antioxidant activity of white ginseng was not recorded in Korea Functional Food Code, while its activity of red ginsengs was recorded. The aim of this study was to evaluate...
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Study of the mechanisms underlying increased glucose absorption in Smilax china L. leaf extract-treated HepG2 cells

Kang YH, Kim DJ, Kim KK, Lee SM, Choe M

  • KMID: 2327149
  • J Nutr Health.
  • 2014 Jun;47(3):167-175.
PURPOSE: Previous studies have shown that treatment with Smilax china L. leaf extract (SCLE) produces antidiabetic effects due to alpha-glucosidase inhibition. In this study, we examined the mechanism underlying these...
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Black rice extract protected HepG2 cells from oxidative stress-induced cell death via ERK1/2 and Akt activation

Yoon J, Ham H, Sung J, Kim Y, Choi Y, Lee JS, Jeong HS, Lee J, Kim D

  • KMID: 2313719
  • Nutr Res Pract.
  • 2014 Apr;8(2):125-131.
BACKGROUND/OBJECTIVES: The objective of this study was to evaluate the protective effect of black rice extract (BRE) on tert-butyl hydroperoxide (TBHP)-induced oxidative injury in HepG2 cells. MATERIALS/METHODS: Methanolic extract from black...
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Human Papilloma Virus Type 16 E7 Oncoprotein Stabilizes p53 Protein but not Induced p53-mediated Apoptosis in HepG2 Cells after gamma-irradiation under Hypoxia

Hwang HJ, Choi EJ, Choi YJ, Lee WT, Park KA, Lee JE

  • KMID: 2092894
  • Korean J Anat.
  • 2007 Jun;40(2):95-106.
Human papilloma virus 16 E6 and E7 oncoproteins are well known to change cell functions, especially through p53 and pRb expression, so we studied their effects on molecular mechanisms and...
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Effect of CLA (Conjugated Linoleic Acid) on the Anti-Atherosclerotic Factors in Human Hepatoma HepG2 Cells

Oh H, Mun H, Lee M

  • KMID: 2269778
  • Korean J Nutr.
  • 2004 Apr;37(3):182-192.
Conjugated linoleic acid (CLA) is the mixture of positional and geometric isomers of linoleic acid (LA), which is found abundantly in dairy products and meats. This study was performed to...
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5-FU Induces Apoptosis of Fas (+), HepG2 Cells Via Activation of Fas-mediated Caspase and Mitochondria Dysfunction

Park C, Yoon KH, Lee YJ, Kim YK, Choi YC, Shin JH, Cho JH, Park R

  • KMID: 1972955
  • Cancer Res Treat.
  • 2002 Apr;34(2):128-138.
PURPOSE: In order to investigate the role of Fas on the chemosensitivity of cancer cells in regards to chemotherapeutic agents, the Fas/FasL signaling pathway of apoptosis was explored in human...
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Cytotoxicity of Paecilomyces tenuipes Against Human Carcinoma Cells, HepG2 and MCF-7 In Vitro

Shim JS, Chang HR, Min EG, Kim YH, Han YH

  • KMID: 2312353
  • Mycobiology.
  • 2001 Sep;29(3):170-172.
The methanolic extract of fruiting body of Paecilomyces tenuipes DGUM 32001 showed significant cytotoxicity against human cancer cells: HepG2 and MCF-7. The methanolic extract was further fractionated with organic solvents...
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Effects of Ethanol in Uptake of Long Chain Fatty Acid in HepG2 Cells

Han NI, Berk PD

  • KMID: 2240629
  • Korean J Gastroenterol.
  • 1998 Apr;31(4):517-524.
Background/Airns: Plasma membrane fatty acid binding protein (FABPpm), a long chain fatty acid (FFA) transporter, is reported to be identical with mitochondrial (m) AST. Alcoholic liver disease (ALD) is characterized...
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Identification and mapping of spiced transcripts of hepatitis B virus in HepG2 cells transfected with the viral DNA

Jeong SM, Park SJ, Rho HM, Kim SH

  • KMID: 1688654
  • J Korean Soc Virol.
  • 1993 Dec;23(2):113-121.
No abstract available.
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The effect of retinoic acid on cell kinetics in bromodeoxyuridine labelled hep G2 cell line

Kim DG, Ahn JK, Jang DS, Kim YY, Lee SR, Lee ST, Ahn DS

  • KMID: 1698340
  • Korean J Med.
  • 1993 Nov;45(5):561-571.
No abstract available.
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Expression of apolipoprotein C-II mRNA in cultured HepG2 cell

Park MJ, Seo DH, Seo KS, Woo JT, Kim JW, Kim YS, Kim KW, Choi YK

  • KMID: 1686739
  • J Korean Soc Endocrinol.
  • 1992 Jun;7(2):127-135.
No abstract available.
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