- TNFα Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis
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Lian W, Liu X, Chen W
- KMID: 2460221
- Yonsei Med J.
- 2019 Nov;60(11):1045-1053.
- doi: 10.3349/ymj.2019.60.11.1045
PURPOSE: To explore the molecular mechanism of the upregulation of multidrug resistance-associated protein 4 (MRP4) in cholestasis. MATERIALS AND METHODS: The mRNA and protein levels of MRP4 in liver samples from... -
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- Xylaroisopimaranin A, a New Isopimarane Derivative from an Endophytic Fungus Xylaralyce sp.
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Bao SS, Liu HH, Zhang XQ, Liu CX, Li XC, Guo ZY
- KMID: 2459964
- Nat Prod Sci.
- 2019 Sep;25(3):228-232.
- doi: 10.20307/nps.2019.25.3.228
Five secondary metabolites, including a new isopimarane derivative xylaroisopimaranin A (1), were isolated from the endophytic fungus Xylaralyce sp. (HM-1), and their structures were elucidated by 1D, 2D NMR, MS... -
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- Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells
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Chung S, Hwang JT, Park JH, Choi HK
- KMID: 2453283
- Nutr Res Pract.
- 2019 Jun;13(3):196-204.
- doi: 10.4162/nrp.2019.13.3.196
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease triggered by epigenetic alterations, including lysine acetylation at histone or non-histone proteins, affecting the stability or transcription of lipogenic... -
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- Emodin exerts protective effect against palmitic acid-induced endoplasmic reticulum stress in HepG2 cells
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Thomas SS, Park S, Cha YS, Kim KA
- KMID: 2444941
- J Nutr Health.
- 2019 Apr;52(2):176-184.
- doi: 10.4163/jnh.2019.52.2.176
PURPOSE: Protein overloading in the endoplasmic reticulum (ER) leads to endoplasmic reticulum stress, which exacerbates various disease conditions. Emodin, an anthraquinone compound, is known to have several health benefits. The... -
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- Antioxidant activity of ethanol extract of Lycium barbarum's leaf with removal of chlorophyll
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Kim JE, Bae SM, Nam YR, Bae EY, Ly SY
- KMID: 2466680
- J Nutr Health.
- 2019 Feb;52(1):26-35.
- doi: 10.4163/jnh.2019.52.1.26
PURPOSE: The aim of this study was to estimate the antioxidant activities of 50%, 70%, and 100% ethanol extracts of Lycium barbarum leaf and chlorophyll removal extract. METHODS: The antioxidant activities... -
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- High-content analysis of in vitro hepatocyte injury induced by various hepatotoxicants
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Tham NT, Hwang SR, Bang JH, Yi H, Park YI, Kang SJ, Kang HG, Kim YS, Ku HO
- KMID: 2434775
- J Vet Sci.
- 2019 Jan;20(1):34-42.
- doi: 10.4142/jvs.2019.20.1.34
In vitro prediction of hepatotoxicity can enhance the performance of non-clinical animal testing for identifying chemical hazards. In this study, we assessed high-content analysis (HCA) using multi-parameter cell-based assays as... -
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- Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver
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Cho KW, Cho DH
- KMID: 2434096
- Yeungnam Univ J Med.
- 2019 Jan;36(1):26-35.
- doi: 10.12701/yujm.2019.00059
BACKGROUND: Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in... -
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- MiR-506 Promotes Natural Killer Cell Cytotoxicity against Human Hepatocellular Carcinoma Cells by Targeting STAT3
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Su Z, Ye X, Shang L
- KMID: 2428274
- Yonsei Med J.
- 2019 Jan;60(1):22-29.
- doi: 10.3349/ymj.2019.60.1.22
PURPOSE: It is well documented that natural killer (NK) cytotoxicity against hepatocellular carcinoma (HCC) cells is impaired in HCC, which might account for the failure of anti-tumor immune response. miRNAs... -
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- XIST Induced by JPX Suppresses Hepatocellular Carcinoma by Sponging miR-155-5p
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Lin XQ, Huang ZM, Chen X, Wu F, Wu W
- KMID: 2428907
- Yonsei Med J.
- 2018 Sep;59(7):816-826.
- doi: 10.3349/ymj.2018.59.7.816
PURPOSE: The influence of X-inactive specific transcript (XIST) and X-chromosome inactivation associated long non-coding RNAs (lncRNAs) just proximal to XIST (JPX) on hepatocellular carcinoma (HCC) remains controversial in light of... -
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- Metabolites profiling and hypolipidemic/hypocholesterolemic effects of persimmon (Diosyros kaki Thumb.) by different processing procedures: in vitro and in vivo studies
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Park SY, Oh EK, Lim Y, Shin JY, Jung HA, Park SY, Lee JH, Choe JS, Kwon O
- KMID: 2419498
- J Nutr Health.
- 2018 Aug;51(4):275-286.
- doi: 10.4163/jnh.2018.51.4.275
PURPOSE: Our previous study demonstrated that persimmon (Diospyros kaki Thumb.) at different stages of ripening provided different protective effects against high-fat/cholesterol diet (HFD)-induced dyslipidemia in rats. In this study, we... -
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- Everolimus Plus Ku0063794 Regimen Promotes Anticancer Effects against Hepatocellular Carcinoma Cells through the Paradoxical Inhibition of Autophagy
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Lee SC, Kim KH, Kim OH, Lee SK, Hong HE, Choi BJ, Jeong W, Kim SJ
- KMID: 2417890
- Cancer Res Treat.
- 2018 Jul;50(3):1023-1038.
- doi: 10.4143/crt.2017.085
PURPOSE: Everolimus only inhibits mammalian target of rapamycin complex 1 (mTORC1), whereas Ku0063794 inhibits both mTORC1 and mTORC2. Although they have similar anticancer effects, their combination has a synergistic effect... -
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- A Compound Mutation (c.953C < G and c.49G < A) Aggravates Functional Impairments of C1-INH in Hep G2 Cells
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Xu YY, Zhi YX
- KMID: 2409065
- Allergy Asthma Immunol Res.
- 2018 May;10(3):285-286.
- doi: 10.4168/aair.2018.10.3.285
No abstract available. -
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- Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease
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Hwang JT, Shin EJ, Chung MY, Park JH, Chung S, Choi HK
- KMID: 2407807
- Nutr Res Pract.
- 2018 Apr;12(2):110-117.
- doi: 10.4162/nrp.2018.12.2.110
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is closely associated with metabolic syndrome. In the present study, we observed the effect of... -
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- Picroside II attenuates fatty acid accumulation in HepG2 cells via modulation of fatty acid uptake and synthesis
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Dhami-Shah H, Vaidya R, Udipi S, Raghavan S, Abhijit S, Mohan V, Balasubramanyam M, Vaidya A
- KMID: 2429085
- Clin Mol Hepatol.
- 2018 Mar;24(1):77-87.
- doi: 10.3350/cmh.2017.0039
BACKGROUND/AIMS: Hepatic steatosis is caused by an imbalance between free fatty acids (FFAs) uptake, utilization, storage, and disposal. Understanding the molecular mechanisms involved in FFAs accumulation and its modulation could... -
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- Hepaprotective Effect of Standardized Ecklonia stolonifera Formulation on CClâ‚„-Induced Liver Injury in Sprague-Dawley Rats
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Byun JH, Kim J, Choung SY
- KMID: 2429062
- Biomol Ther.
- 2018 Mar;26(2):218-223.
- doi: 10.4062/biomolther.2017.199
The liver is an essential organ for the detoxification of exogenous xenobiotics, drugs and toxic substances. The incidence rate of non-alcoholic liver injury increases due to dietary habit change and... -
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- Anti-hyperglycemic effects and signaling mechanism of Perilla frutescens sprout extract
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Kim DH, Kim SJ, Yu KY, Jeong SI, Kim SY
- KMID: 2429015
- Nutr Res Pract.
- 2018 Feb;12(1):20-28.
- doi: 10.4162/nrp.2018.12.1.20
BACKGROUND/OBJECTIVES: Perilla frutescens (L.) Britton var. (PF) sprout is a plant of the labiate family. We have previously reported the protective effects of PF sprout extract on cytokine-induced β-cell damage.... -
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- Glutamine synthetase mediates sorafenib sensitivity in β-catenin-active hepatocellular carcinoma cells
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Sohn BH, Park IY, Shin JH, Yim SY, Lee JS
- KMID: 2438351
- Exp Mol Med.
- 2018 Jan;50(1):e421.
- doi: 10.1038/emm.2017.174
The gene encoding β-catenin is frequently mutated in hepatocellular carcinoma cells. While the oncogenicity of β-catenin has been extensively studied, β-catenin’s role in hepatocellular carcinoma tumor metabolism is currently less... -
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- Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome
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Kim M, Lee HA, Cho HM, Kang SH, Lee E, Kim IK
- KMID: 2398552
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):23-33.
- doi: 10.4196/kjpp.2018.22.1.23
Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors... -
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- In vitro Protective Effects of Glehnia Littoralis on Alpha-amanitin Induced Hepatotoxicity
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Kim BH, Sun KH, Kim SP, Park Y
- KMID: 2402615
- J Korean Soc Clin Toxicol.
- 2017 Dec;15(2):107-115.
- doi: 10.22537/jksct.2017.15.2.107
PURPOSE: Glehnia littoralis has been used to treat ischemic stroke, phlegm, cough, systemic paralysis, antipyretics and neuralgia. The pharmacological mechanisms of Glehnia littoralis include calcium channel block, coumarin derivatives, anticoagulation,... -
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- 17-DMAG has the Potentiated Anticancer Effects Against Hepatocellular Carcinoma Cells by Transfection of the Gene Encoding Hepatitis B Viral X Protein
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Lee CS, Kim OH, Hong HE, Jeon SJ, Won SS, Kim SJ
- KMID: 2396567
- J Liver Cancer.
- 2017 Sep;17(2):126-135.
- doi: 10.17998/jlc.17.2.126
BACKGROUND/AIMS: Hepatitis B viral protein X (HBx) is implicated in the pathogenesis of hepatocellular carcinoma (HCC) as well as the elevation of heat shock proteins (HSPs) after hepatitis B virus... -
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