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Current Understanding of Dendritic Cells in Atherosclerosis

Choi JH

Dendritic cells (DCs), first identified in 1973, have been shown to be the principal cells involved in antigen presentation to T cells, and are more potent in the presentation of...
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The Niche of Follicular Helper T Cells in Systemic Autoimmune Diseases

Jang E, Youn J

Production of thymus-dependent antibodies by autoreactive B cells requires help from T cells. Follicular helper T (Tfh) cells are a unique lineage of CD4+ T subsets present in the follicles...
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Interleukin-17 in the Inflammatory Bowel Disease

Lee CR, Park SG

Inflammatory bowel diseases(IBD), including Crohn's disease and ulcerative colitis, are chronic inflammatory states of the intestinal tract. While the exact mechanisms inducing chronic inflammation are still unclear, it is hypothesized...
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Role of Dendritic Cells in the Airway Mucosa

Cho SH

Dendritic cells (DC) are located at the environment-host interface and are continuously exposed to a vast array of foreign proteins and pathogens. The major role of DC is to sample...
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Mechanism of Allergic Asthma Pathogenesis by Protease Allergen

Lee SH

Asthma is a complex immune mediated chronic inflammatory lung disease characterized by chronic inflammation of the airways, airway hyper-responsiveness and airway obstruction, and the prevalence of this disease has increased...
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Influence of Polycomb Proteins and Epigenetic Transcriptional Modifiers on the Development and Activation of T Lymphocytes

Chun T

Transcriptional regulation of a gene is not always correlated with genetic information inherited from parents because the transcription of specific genes is often governed by the modification of chromatin structure....
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Natural Killer Cell and Cancer Immunotherapy

Kim HS

Cancer remains the leading cause of death worldwide despite intense efforts in developing innovative treatments. Current approaches in cancer therapy are mainly directed to a selective targeting of cancer cells...
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Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells

Park HJ, Kim DH, Choi JM

Follicular helper T cells (Tfh) play a significant role in providing T cell help to B cells during the germinal center reaction, where somatic hypermutation, affinity maturation, isotype class switching,...
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Targeting Interleukin-17 and Th17 in Immune Inflammatory Diseases

Cho MR

Th17 cells (Th17) are a distinct lineage of CD4+ T cells that secrete high amounts of IL-17 under orphan nuclear receptor retinoic acid receptor-related orphan receptor gammat (RORgammat) which is...
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Hypereosinophilia-associated Diseases and the Therapeutic Agents in Development

Chung IY

Eosinophil is one of the most enigmatic leukocytes that plays pleiotropic roles in initiation and propagation of inflammatory conditions, modulation of innate and adaptive immune responses, homeostasis, and remodeling and...
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