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Generation of Induced Pluripotent Stem Cells from Lymphoblastoid Cell Lines by Electroporation of Episomal Vectors

Kim M, Park J, Kim S, Han DW, Shin B, Schöler HR, Kim J, Kim KP

Background and Objectives: Lymphoblastoid cell lines (LCLs) deposited from disease-affected individuals could be a valuable donor cell source for generating disease-specific induced pluripotent stem cells (iPSCs). However, generation of iPSCs...
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Dexmedetomidine attenuates subarachnoid hemorrhage-induced acute lung injury through regulating autophagy and TLR/NFκB signaling pathway

Han DW, Oh JE, Lim BJ, Han Y, Song Y

Background: Acute lung injury (ALI) is the most serious complication of subarachnoid hemorrhage (SAH). We investigated role of autophagy and inflammatory signaling pathways in lung damage and therapeutic effects of...
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Robust and Reproducible Generation of Induced Neural Stem Cells from Human Somatic Cells by Defined Factors

Kwak TH, Hali S, Kim S, Kim J, La H, Kim KP, Hong KH, Shin CY, Kim NH, Han DW

Background and Objectives: Recent studies have described direct reprogramming of mouse and human somatic cells into induced neural stem cells (iNSCs) using various combinations of transcription factors. Although iNSC technology...
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Autumn olive (Elaeagnus umbellata Thunb.) berry reduces fasting and postprandial glucose levels in mice

Kim JI, Baek HJ, Han DW, Yun JA

BACKGROUND/OBJECTIVES: Fasting and postprandial hyperglycemia should be controlled to avoid complications of diabetes mellitus. This study investigated the effects of autumn olive (Elaeagnus umbellata Thunb.) berry (AOB) on fasting and...
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Do you believe that processed EEG helps to prevent intraoperative awareness?

Han DW

No abstract available.
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A Simulation Study of Propofol Effect-Site Concentration for Appropriate Sedation in Pediatric Patients Undergoing Brain MRI: Pharmacodynamic Analysis

Na SH, Song Y, Kim SY, Byon HJ, Jung HH, Han DW

PURPOSE: We aimed to establish the propofol effect-site concentration (Ce) for appropriate sedation by pharmacodynamic analysis and to determine the propofol Ce during occurrence of sedation-related side effects in pediatric...
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Brain and lung: dangerous crosstalk

Han DW

No abstract available.
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Pharmacodynamic Estimate of Propofol-Induced Sedation and Airway Obstruction Effects in Obstructive Sleep Apnea-Hypopnea Syndrome

Koo BN, Shin S, Kim SY, Kang YR, Jeong KH, Han DW

PURPOSE: Sedatives must be carefully titrated for patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) as oversedation may lead to disastrous respiratory outcomes. This study aimed to investigate the relations between...
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Modeling of Recovery Profiles in Mentally Disabled and Intact Patients after Sevoflurane Anesthesia; A Pharmacodynamic Analysis

Shin TJ, Noh GJ, Koo YS, Han DW

PURPOSE: Mentally disabled patients show different recovery profiles compared to normal patients after general anesthesia. However, the relationship of dose-recovery profiles of mentally disabled patients has never been compared to...
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Pharmacokinetic and pharmacodynamic modeling in anesthetic field

Han DW

  • KMID: 1797465
  • Anesth Pain Med.
  • 2014 Apr;9(2):77-86.
Models are simplified descriptions of true biological processes. Pharmacokinetic/pharmacodynamic (PK/PD) modeling is a mathematical description on the relationship between pharmacokinetics and pharmacodynamics. The PK/PD modeling allows estimation of PK/PD parameters...
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Effect of Dexmedetomidine on the Corrected QT and Tp-e Intervals during Spinal Anesthesia

Kim Y, Kim SY, Lee JS, Kong HJ, Han DW

  • KMID: 2386485
  • Yonsei Med J.
  • 2014 Mar;55(2):517-522.
PURPOSE: The aim of this study is to evaluate the effect of dexmedetomidine on corrected QT (QTc) and Tp-e intervals in patients undergoing spinal anesthesia. MATERIALS AND METHODS: We studied 50...
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A brief cardiac arrest due to saline irrigation during surgery for infratentorial cerebellar tumor

Kim Y, Chang CH, Ham SY, Han DW

No abstract available.
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Neurobiology, pharmacokinetics and pharmacodynamics of drug abuse

Kim SY, Lee JS, Han DW

All drugs of abuse, like neural rewarding behaviors such as sex and eating, increase extra-cellular dopamine (DA) levels in the nucleus accumbens (NA), which is a part of the common...
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Conversion of orotracheal to nasotracheal intubation using a fiberoptic bronchoscope in a patient with intraoral hematoma

Lee HJ, Nam SB, Han DW, Chang CH

No abstract available.
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Association between opioid receptor gene polymorphism and postoperative pain response in Koreans

Lee WK, Lee JR, Han DW, Kim KH, Choi SH

  • KMID: 1742027
  • Anesth Pain Med.
  • 2012 Oct;7(4):343-347.
BACKGROUND: The objective of this study was to investigate the association between A118G single nucleotide polymorphism (SNP) of human micro-opioid receptor (OPRM1) gene and the postoperative pain response in Korean...
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Heart rate variability predicts the extent of corrected QT interval prolongation after tracheal intubation

Kim JY, Shim YH, Choi SH, Ham SY, Han DW

  • KMID: 2169147
  • Anesth Pain Med.
  • 2012 Jan;7(1):45-50.
BACKGROUND: Corrected QT (QTc) interval can be modulated by sympathetic and parasympathetic balance. Tracheal intubation causes significant prolongation of the QTc interval due to sympathetic stimulation. This study was designed...
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Current status of infertility counseling in Korea

Kim RH, Lee WM, Kim YJ, Sung YM, Hoh JK, Han DW, Choi YM, Hwang JH

OBJECTIVE: The recent fertility decline deepened concern about the emotional side of infertility problems as well as social, ethical, legal and psychological aspect and increased awareness of the importance of...
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The effect of beta1-adrenergic receptor gene polymorphism on prolongation of corrected QT interval during endotracheal intubation under sevoflurane anesthesia

Park K, Jang SB, Kweon TD, Kim JH, Han DW

BACKGROUND: The hemodynamic responses to endotracheal intubation are associated with sympathoadrenal activity. Polymorphisms in the beta1-adrenergic receptor (beta1AR) gene can alter the pathophysiology of specific diseases. The aim of this...
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Biomechanical Factors Associated with Plantar Fasciitis in Non-obese Patients

Lee JH, Kim SB, Lee KW, Han DW

The purpose of this study was to identify the biomechanical factors that correlate with plantar fasciitis in non-obese patients whose body mass index were below 25 kg/m2. The subjects were...
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Evaluating the Clinical Symptoms of Neonates with Suspected Dysphagia

Lee KW, Kim SB, Lee JH, Kim TH, Han DW, Kim MJ

  • KMID: 2327342
  • J Korean Acad Rehabil Med.
  • 2011 Apr;35(2):265-271.
OBJECTIVE: To evaluate the prevalence of dysphagia in neonates who showed abnormal findings on videofluoroscopic swallowing studies (VFSSs), and to compare the accuracy of the clinical evaluation with the VFSS...
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