- Diagnostic Role of Bile Pigment Components in Biliary Tract Cancer
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Ahn KS, Kang KJ, Kim YH, Kim TS, Cho KB, Kim HS, Baek WK, Suh SI, Han JY
- KMID: 2547500
- Biomol Ther.
- 2023 Nov;31(6):674-681.
- doi: 10.4062/biomolther.2023.010
Bile pigment, bilirubin, and biliverdin concentrations may change as a results of biliary tract cancer (BTC) altering the mechanisms of radical oxidation and heme breakdown. We explored whether changes in... -
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- Suppression of Lipopolysaccharide-Induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae
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Ji SY, Cha HJ, Neelaka Molagoda IM, Kim MY, Kim SY, Hwangbo H, Lee H, Kim GY, Kim DH, Hyun JW, Kim HS, Kim S, Jin CY, Choi YH
- KMID: 2522257
- Biomol Ther.
- 2021 Nov;29(6):685-696.
- doi: 10.4062/biomolther.2021.030
In this study, we investigated the inhibitory effect of 5-aminolevulinic acid (ALA), a heme precursor, on inflammatory and oxidative stress activated by lipopolysaccharide (LPS) in RAW 264.7 macrophages by estimating... -
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- Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption
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Zhang Z, Zhang Q, Li F, Xin Y, Duan Z
- KMID: 2513485
- Biomol Ther.
- 2021 Mar;29(2):175-183.
- doi: 10.4062/biomolther.2020.131
The mitogen-activated protein kinase (MAPK) pathway controls intestinal epithelial barrier permeability by regulating tight junctions (TJs) and epithelial cells damage. Heme oxygenase-1 (HO-1) and carbon monoxide (CO) protect the intestinal... -
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- Mechanisms of Resorcinol Antagonism of Benzo[a]pyrene-Induced Damage to Human Keratinocytes
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Lee SE, Kwon K, Oh SW, Park SJ, Yu E, Kim H, Yang S, Park JY, Chung WJ, Cho JY, Lee J
- KMID: 2513491
- Biomol Ther.
- 2021 Mar;29(2):227-233.
- doi: 10.4062/biomolther.2020.083
Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon and ubiquitous environmental toxin with known harmful effects to human health. Abnormal phenotypes of keratinocytes are closely associated with their exposure to B[a]P.... -
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- Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway
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Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y
- KMID: 2500502
- Biomol Ther.
- 2020 May;28(3):259-266.
- doi: 10.4062/biomolther.2019.123
The present research work primarily investigated whether spinosin has the potential of improving the pathogenesis of Alzheimer’s disease (AD) driven by β-amyloid (Aβ) overproduction through impacting the procession of amyloid... -
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- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways
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Park JS, Leem YH, Park JE, Kim DY, Kim HS
- KMID: 2442009
- Biomol Ther.
- 2019 Feb;27(2):178-184.
- doi: 10.4062/biomolther.2018.234
Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether β-Lapachone (β-LAP), a... -
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- The Novel Neuroprotective Compound KMS99220 Has an Early Anti-neuroinflammatory Effect via AMPK and HO-1, Independent of Nrf2
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Lee JA, Kim HR, Kim J, Park KD, Kim DJ, Hwang O
- KMID: 2424735
- Exp Neurobiol.
- 2018 Oct;27(5):408-418.
- doi: 10.5607/en.2018.27.5.408
We have previously reported a novel synthetic compound KMS99220 that prevented degeneration of the nigral dopaminergic neurons and the associated motor deficits, suggesting a neuroprotective therapeutic utility for Parkinson's disease.... -
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- Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells
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Moon H, Jang JH, Jang TC, Park GH
- KMID: 2429057
- Biomol Ther.
- 2018 Mar;26(2):175-181.
- doi: 10.4062/biomolther.2018.009
Carbon monoxide (CO) is well-known as toxic gas and intrinsic signaling molecule such as neurotransmitter and blood vessel relaxant. Recently, it has been reported that low concentration of CO exerts... -
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- Pulegone Exhibits Anti-inflammatory Activities through the Regulation of NF-κB and Nrf-2 Signaling Pathways in LPS-stimulated RAW 264.7 cells
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Roy A, Park HJ, Abdul QA, Jung HA, Choi JS
- KMID: 2409606
- Nat Prod Sci.
- 2018 Mar;24(1):28-35.
- doi: 10.20307/nps.2018.24.1.28
Pulegone is a naturally occurring organic compound obtained from essential oils from a variety of plants. The aim of this study was to investigate the anti-inflammatory effects through the inhibitory... -
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- Estragole Exhibits Anti-inflammatory Activity with the Regulation of NF-κB and Nrf-2 Signaling Pathways in LPS-induced RAW 264.7 cells
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Roy A, Park HJ, Jung HA, Choi JS
- KMID: 2409604
- Nat Prod Sci.
- 2018 Mar;24(1):13-20.
- doi: 10.20307/nps.2018.24.1.13
Estragole is a naturally occurring phenylpropanoid obtained from essential oils found in a broad diversity of plants. Although the phenylpropanoids show many biological activities, clear regulation of the inflammatory signaling... -
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- Luteolin 5-O-glucoside from Korean Milk Thistle, Cirsium maackii, Exhibits Anti-Inflammatory Activity via Activation of the Nrf2/HO-1 Pathway
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Jung HA, Roy A, Abdul QA, Kim HR, Park HJ, Choi JS
- KMID: 2393799
- Nat Prod Sci.
- 2017 Sep;23(3):183-191.
- doi: 10.20307/nps.2017.23.3.183
Luteolin 5-O-glucoside is the major flavonoid from Korean thistle, Cirsium maackii. We previously reported the anti-inflammatory activities of luteolin 5-O-glucoside in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. In this study, we... -
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- RhGLP-1 (7–36) protects diabetic rats against cerebral ischemia-reperfusion injury via up-regulating expression of Nrf2/HO-1 and increasing the activities of SOD
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Fang Y, Liu X, Zhao L, Wei Z, Jiang D, Shao H, Zang Y, Xu J, Wang Q, Liu Y, Peng Y, Yin X
- KMID: 2388693
- Korean J Physiol Pharmacol.
- 2017 Sep;21(5):475-485.
- doi: 10.4196/kjpp.2017.21.5.475
The present study aimed to explore the neuroprotective effect and possible mechanisms of rhGLP-1 (7–36) against transient ischemia/reperfusion injuries induced by middle cerebral artery occlusion (MCAO) in type 2 diabetic... -
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- Changes in HO-1, HSP70 and iNOS Expressions in the Rat Liver after Remote Ischemic Preconditioning
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Jeon SK, Seo YK, Paik DJ
- KMID: 1982465
- Korean J Phys Anthropol.
- 2012 Dec;25(4):167-175.
- doi: 10.11637/kjpa.2012.25.4.167
Ischemic preconditioning (IP), short pre-treatment sublethal ischemia, induces a state of protection against subsequent prolonged ischemia-reperfusion. The purpose of this study was to investigate the expression of HO-1, HSP70, and... -
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- Cilostazol Inhibits Vascular Smooth Muscle Cell Proliferation and Reactive Oxygen Species Production through Activation of AMP-activated Protein Kinase Induced by Heme Oxygenase-1
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Kim JE, Sung JY, Woo CH, Kang YJ, Lee KY, Kim HS, Kwun WH, Choi HC
- KMID: 1448925
- Korean J Physiol Pharmacol.
- 2011 Aug;15(4):203-210.
- doi: 10.4196/kjpp.2011.15.4.203
Cilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular cAMP levels and activates protein kinase A, thereby inhibiting vascular smooth muscle cell (VSMC) proliferation. We investigated whether AMP-activated... -
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- HO-1 Induced by Cilostazol Protects Against TNF-alpha-associated Cytotoxicity via a PPAR-gamma-dependent Pathway in Human Endothelial Cells
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Park SY, Bae JU, Hong KW, Kim CD
- KMID: 2285411
- Korean J Physiol Pharmacol.
- 2011 Apr;15(2):83-88.
- doi: 10.4196/kjpp.2011.15.2.83
A large body of evidence has indicated that induction of endogenous antioxidative proteins seems to be a reasonable strategy for delaying the progression of cell injury. In our previous study,... -
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- The Stem Bark of Kalopanax pictus Exhibits Anti-inflammatory Effect through Heme Oxygenase-1 Induction and NF-kappaB Suppression
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Bang SY, Park GY, Park SY, Kim JH, Lee YK, Lee SJ, Kim Y
- KMID: 2150677
- Immune Netw.
- 2010 Dec;10(6):212-218.
- doi: 10.4110/in.2010.10.6.212
BACKGROUND: The stem bark of Kalopanax pictus (KP) has been used in traditional medicine to treat rheumatoidal arthritis, neurotic pain and diabetes mellitus in China and Korea. In this study,... -
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- Aprotinin Inhibits Vascular Smooth Muscle Cell Inflammation and Proliferation via Induction of HO-1
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Lee DH, Choi HC, Lee KY, Kang YJ
- KMID: 2071661
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):123-129.
- doi: 10.4196/kjpp.2009.13.2.123
Aprotinin is used clinically in cardiopulmonary bypass surgery to reduce transfusion requirements and the inflammatory response. The mechanism of action for the anti-inflammatory effects of aprotinin is still unclear.... -
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- Effects of Heme Oxygenase-1 Inducer and Inhibitor on Experimental Autoimmune Uveoretinitis
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Jang JU, Lee SH, Choi CU, Bahk SC, Chung HT, Yang YS
- KMID: 754643
- Korean J Ophthalmol.
- 2007 Dec;21(4):238-243.
- doi: 10.3341/kjo.2007.21.4.238
PURPOSE: Experimental autoimmune uveoretinitis (EAU) is an animal model of posterior uveitis and heme oxygenase-1 (HO-1) is a well-known anti-oxidant factor. However, there is no report a protective role... -
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- HO-1 Reduces the Severity of Trinitrobenzene Sulfonic Acid-induced Colitis through Suppression of NF-kappaB Activation
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Lee SP, Song JH, Jang SJ
- KMID: 1510216
- Korean J Anat.
- 2006 Dec;39(6):425-432.
Heme oxygenage-1 (HO-1), rate-limiting enzyme in heme catabolism, has been known to show strong immune-suppressive properties although its mechanisms are not completely understood. In this study, the authors investigated the... -
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