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Anti-tumor activity and mitochondrial stability of disulfiram in HL-60 cells

Disulfiram (DSF) is a member of the dithiocarbamate family that can bind copper. Recent studies have shown that DSF has anti-cancer activities, but the mechanism has not been clarified. Therefore,...
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Sonication Induces Apoptosis in HL-60 Cells

Choi M, Seo I, Suh SI, Suh MH, Baek WK

To investigate a specific mechanism of apoptosis induced by sonication, we applied 20 kHz ultrasound to leukemia cell line HL-60 with different intensities (0-60 W/cm2) and time durations (0-100 sec)....
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Investigation of Chemotactic Activities in Differentiated HL-60 Cells by a Time-lapse Videomicroscopic Assay

Jung YJ, Woo SY, Ryu KH, Jang MH, Miyasaka M, Seoh JY

BACKGROUND: Chemotaxis is one of the cardinal functions of leukocytes, which enables them to be recruited efficiently to the right place at the right time. Analyzing chemotactic activities is important...
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Activation of Caspase-3 in Hydrogen Peroxide-Induced Apoptosis of Human Leukemia HL 60 Cells

Jeon S, Woo CW, Lee J, Sohn J, Lee KC, Son C, Lee J

  • KMID: 2278318
  • Korean J Pediatr Hematol Oncol.
  • 2004 Oct;11(2):228-235.
PURPOSE: Reactive oxygen species have been recognized as a common signaling mediator in diverse stimuli-induced apoptosis and hydrogen peroxide is a natural one of those reactive oxygen species. This study...
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Induction of Apoptosis by (-)-epigallocatechin-3-gallate in HL-60 Cells

Lee HM, Kim YJ, Park TS

  • KMID: 1618344
  • Korean J Nutr.
  • 2003 May;36(4):382-388.
(-)-Epigallocatechin-3-gallate (EGCG) is a polyphenolic compound found in peen tea leaves, and has been known to be one of the most potent catechin species which inhibits cell growth most possibly...
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Expression of IAP Genes During TPA-Induced Differentiation of HL-60 Cells

Baek WK, Kwon TK, Park JW, Suh MH

  • KMID: 1615432
  • J Bacteriol Virol.
  • 2003 Mar;33(1):113-118.
HL-60 cells (human promyelocytic leukemia cells) differentiate into the monocyte/macrophage like cells that die spontaneously by apoptosis when treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). It is known that inhibitors of apoptosis proteins...
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Diallyl Disulfide Enhances Daunorubicin-Induced Apoptosis of HL-60 Cells

Koo BS, Yang JY, Shon HS, Kwon KB, Jhee EJ

  • KMID: 1618395
  • Korean J Nutr.
  • 2003 Oct;36(8):828-833.
Dially disulfide (DADS), a component of garlic (Allium sativum), has been known to exert potent chemopreventive activity against various cancers. In this study, the synergistic effect of DADS and daunorubicin...
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Arsenic Trioxide Induces Apoptosis of HL-60 Cells via Activation of Intrinsic Caspase Protease with Mitochondrial Dysfunction

Jung BH, Park C, Kim HR, Park MR

  • KMID: 1804473
  • Cancer Res Treat.
  • 2002 Aug;34(4):308-315.
Arsenic trioxide (As2O3) was introduced into the treatment of refractory or relapsed acute promyelocytic leukemia and showed a striking effectiveness in China and United States multicenter study. However, the mechanistic...
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Cadmium-induced Apoptosis in HL-60 Cells Via Signal Transduction

Kim NS, Oh GJ, Cho KH, Hyun MS, Kim YC, Sung TH, Youm JH, Kwon KS

  • KMID: 2028171
  • Korean J Occup Environ Med.
  • 2002 Mar;14(1):1-12.
OBJECTIVES: Apoptosis is a process of active cell death, distinct from necrosis and characterized by specific morphological and biochemical features. Apoptosis induced by metals and metal-related deleterious conditions has only...
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Interferon consensus sequence binding protein: Not essential for interferon alpha-mediated antiviral response to vesicular-stomatitis virus infection in HL-60 cells

Park BK

BACKGROUND: The role of the interferon consensus sequence binding protein (ICSBP), a member of interferon regulatory factor family, in protecting against a vesicular stomatitis virus (VSV) infection has not been...
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A Study on Apoptotic Signaling Pathway in HL-60 Cells Induced by Radiation

Kim HJ, Moon SK, Lee JH, Moon SR

  • KMID: 2097162
  • J Korean Soc Ther Radiol Oncol.
  • 2001 Jun;19(2):153-162.
PURPOSE: The mechanical insights of death of cancer cells by ionizing radiation are not yet clearly defined. Recent evidences have demonstrated that radiation therapy may induce cell death via activation...
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Interferon-gamma susceptibility of HL-60 cells, mononuclear cells of umbilical ord blood and bone marrow

Cheong HJ, Hong DS, Kim SJ, Cheong JH, Lee JY, Lee NS, Park SK, Won JH, Park HS, Kim SI

No abstract available.
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Analysis of X irradiation related genes in HL60 cells using cDNA microarray

Park KU, Hwang MS, Suh SI, Suh MH, Kwon TK, Park JW, Cho JW, Choi EJ, Baek WK

  • KMID: 2146874
  • J Korean Soc Microbiol.
  • 2000 Aug;35(4):299-308.
Recently developed cDNA microarray or DNA chip technology allows expression monitoring of expression of hundreds and thousands of genes simultaneously and provides a format for identifying genes as well as changes in their...
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Transcriptional Regulation of H2B Histone Gene Expression by Nocodazole in HL-60 Cells

Lim K, Hong YG, Lee MS, Son MY, Yun KA, Park JI, Yoon WH, Park SK, Hwang BD

  • KMID: 2175113
  • J Korean Cancer Assoc.
  • 2000 Apr;32(2):407-416.
PURPOSE: Nocodazole, a microtubule disrupting reagent, is known to arrest cells in the M phase, To gain insight on the regulatory mechanism of H2B histone gene expression by nocodazole in HL-60 cell,...
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Increased Growth of Human Leukemic HL-60 Cells by Dimethyl Sulfoxide and Dimethylformamide

Kang IC, Oh HM

  • KMID: 1550777
  • Korean J Immunol.
  • 1999 Sep;21(3):285-289.
A recent study has proposed that dimethyl sulfoxide (DMSO) increases the number of HL-60 cells in high cell density conditions by inhibiting cell density-dependent apoptosis. We observed that dimethylformamide (DMF),...
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Cloning of a Glutathione S-Transferase Decreasing During Differentiation of HL60 Cell Line

Kim JC, Park IK, Lee KB, Sohn SK, Kim MK, Kim JC

  • KMID: 2323722
  • J Korean Soc Ther Radiol Oncol.
  • 1999 Jun;17(2):151-157.
PURPOSE: By sequencing the Expressed Sequence Tags of human dermal papilla cDNA library, we identified a clone named K872 of which the expression decreased during differentiation of HL60 cell line....
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Fcr Receptor and Mac-1 Expression and Functional Differentiation of HL-60 Cells by All-trans Retinoic Acid

Kim HS, Kim KH, Kim GH, Seoh JY

  • KMID: 2142388
  • J Korean Pediatr Soc.
  • 1999 Apr;42(4):462-471.
PURPOSE: During differentiation of HL-60 cells by all-trans retinoic acid(ATRA), we analyzed the expression of Fcr receptors and Mac-1 by molecules of equivalent soluble fluorochromes(MESF) and functional studies. METHODS: HL-60...
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Functional Differentiation of HL-60 Cells by Dimethylsulfoxide and Phorbol 12-myristate 13-acetate

Kim HS, Kim KH, Kim GH, Seoh JY

  • KMID: 1946339
  • J Korean Pediatr Soc.
  • 1999 Mar;42(3):355-363.
PURPOSE: During hematopoietic differentiation of HL-60 cells by DMSO and PMA, we demonstrated functional changes of HL-60 cells-phagocytic activity, respiratory burst, antibody-dependent cell-mediated cytotoxicity(ADCC) and opsonophagocytic activity. METHODS: HL-60 cells(ATCC...
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The Differentiation of HL-60 Cells Causes to Lose their Ability to Express TNF mRNA

Kim JH, Han SJ, Park CS, Chung IY

  • KMID: 1550795
  • Korean J Immunol.
  • 1999 Mar;21(1):47-53.
It is well known that HL-60 cell, a human promyelocytic line, is differentiated into eosinophil-like cells in the presence of butyric acid, and thus the differentiated HL-60 cells have been...
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Telomerase Activity in HL-60 Cells After Treatment with Differentiating Agents

Kim IH, Kim SJ, Cheong HJ, Park SK, Lee GT, Won JH, Suh WS, Baick SH, Hong DS, Park HS

  • KMID: 1534096
  • Korean J Hematol.
  • 1999 Feb;34(1):107-117.
BACKGROUND: Telomeres are repetitive DNA fragments at the termini of chromosomes functioning as stabilizing elements of the DNA. A ribonucleoprotein polymerase, called telomerase, is responsible for the synthesis of such...
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