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Transcriptome Analysis Identifies Altered Biological Processes and Novel Markers in Human Immunodeficiency Virus-1 Long-Term Non-Progressors

Lee D, Yoon CH, Choi SY, Kim JE, Cho YK, Choi BS, Park J

Background: The latent reservoir of Human Immunodificiency Virus-1 (HIV-1) has been a major barrier to the complete eradication of HIV-1 and the development of HIV therapy. Longterm non-progressors (LTNPs) are...
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An Overview of Human Immunodeficiency Virus-1 Antiretroviral Drugs: General Principles and Current Status

Shin YH, Park CM, Yoon CH

Treatment with highly active antiretroviral therapy (HAART) can prolong a patient's lifespan by disrupting pivotal steps in the replication cycle of the human immunodeficiency virus-1 (HIV-1). However, drug resistance is...
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Long-Term Stability of HBV, HCV, and HIV-1 National Reference Standards for in vitro Diagnostic Medical Devices Intended to Be Used for the Nucleic Acid Amplification Test

Choi KY, Youn KW, Cha YJ, Min HK, Kim J

BACKGROUND: National reference standards are essential to the quality assessment and regulatory approval of in vitro diagnostic medical devices. However, the long-term stability of national reference standards has not been...
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Cytotoxic Effects of Gallic Acid and its Derivatives Against HIV-I-infected Microglia

Jeong JJ, Lee YS, Kim DH

In the previous study, we found that flavonoids and ginsenosides exhibited high eliminate rates of human immunodeficiency virus type 1 (HIV-1) D3-transfected macrophages. Based on these findings, here we synthesized...
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HIV-1 Tat Protein Promotes Amyloid beta Generation and Tau Phosphorylation in Rat Hippocampal Slices

Lee EO, Jhang KA, An YW, Ju W, Chong YH

HIV-1 Tat protein has been implicated as a causative agent in the pathogenesis of HIV-1-associated neurocognitive disorder (HAND) and Alzheimer's disease (AD)-like pathology in HIV-1 infected patients. Here, we provide...
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Characterization of Gp41 Polymorphisms in the Fusion Peptide Domain and T-20 (Enfuvirtide) Resistance-Associated Regions in Korean HIV-1 Isolates

Jang DH, Yoon CH, Choi BS, Chung YS, Kim HY, Chi SG, Kim SS

HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, we...
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HIV-1 Tat Protein-dependent Cytotoxicity is Attenated by 15-deoxy-Delta12,14-Prostaglandin J2 in Rat Hippocampal Slices: Involvement of the ERK1/2 Signaling Pathway

Lee EO, Yang JH, Kim JH, Woo SY, Chong YH

15-deoxy-delta12,14 prostaglandin J2 (15d-PGJ2) may hold promise in treatment of the pathologies associated with human immunodeficiency virus (HIV) infection of the central nervous system. However, its precise role and neuroprotective...
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Analysis for Human Immunodeficiency Virus 1 Subtype in Korean Blood Donors

Cho YJ, Kim MH, Kwon SY, Cho NS, Yoon KW, Jee YH, Choi KY

  • KMID: 1424272
  • Korean J Blood Transfus.
  • 2012 Dec;23(3):210-216.
BACKGROUND: Genetic variants of virus appear to differ depending on the country, race, infection route, and so on. To characterize the main HIV subtype in infected blood donors and inquire...
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Neutralizing Antibody Responses and Evolution of the Viral Envelope in the Course of HIV-1 Korean Clade B Infection

Shin BG, Yun MR, Kim SS, Kim GJ

Objectives HIV is able to continuously adapt to and evade the evolving neutralizing antibody responses of the host. We investigated the ability of HIV variants to evade neutralizing antibodies in order...
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Ingenol Protects Human T Cells From HIV-1 Infection

Hong KJ, Lee HS, Kim Ys, Kim SS

Objectives Many natural compounds have been investigated as drug candidates to prevent human immunodeficiency virus (HIV) with low cytotoxicity. We tested whether ingenol from Euphorbia ingens exerts anti-HIV effects in human T...
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Enhanced Induction of T Cell Immunity Using Dendritic Cells Pulsed with HIV Tat and HCMV-pp65 Fusion Protein In Vitro

Park JS, Park SY, Cho HI, Sohn HJ, Kim TG

BACKGROUND: Cytotoxic T lymphocytes (CTLs) appear to play an important role in the control and prevention of human cytomegalovirus (HCMV) infection. The pp65 antigen is a structural protein, which has...
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Efficiency of Recombinant Bacille Calmette-Guerin in Inducing Humoral and Cell Mediated Immunities against Human Immunodeficiency Virus Type 1 Third Variable Domain in Immunized Mice

Kim YJ

PURPOSE: The third variable (V3) loop of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein has been intensively studied for AIDS vaccine development. Bacille Calmette-Guerin (BCG) is widely used...
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Antiretroviral Genotypic Resistance Mutations in HIV-1 Infected Korean Patients with Virologic Failure

Chin BS, Choi JY, Choi JY, Kim GJ, Kee MK, Kim JM, Kim SS

Resistance assays are useful in guiding decisions for patients experiencing virologic failure (VF) during highly-active antiretroviral therapy (HAART). We investigated antiretroviral resistance mutations in 41 Korean human immunodeficiency virus type...
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Evaluation of OraQuick Advance Rapid HIV-1/2 Antibody Test as a Screening Test for HIV Infection

Choi TY, Seo YI, Kim TH, Shin JW, Park R

BACKGROUND: For the diagnosis of HIV infection, enzyme immunoassay (EIA) or chemiluminescence immunoassay (CLIA) is commonly used as a screening test. Although these methods have a high sensitivity and low...
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Rapid Diagnosis of Human Immunodeficiency Virus Infection Using OraQuick(r) Advance Rapid HIV-1/2 Antibody Test

Lee EJ, Kim TH, Kim SH, Kim JH, Oh BJ, Kim YS, Lim KS, Woo JH

BACKGROUND: From medical care perspective regarding HIV, early detection of HIV is critical in effectively managing its sequelae. People who are aware of the fact that they are infected with...
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Characteristics of Human Immunodeficiency Virus Type 1 Reactive Blood Donors Following Nucleic Acid Amplification Test Screening

Lee JS, Yoon MJ, Kang JW, Kim JY, Seo DH, Park Q, Cho NS

  • KMID: 1909656
  • Korean J Blood Transfus.
  • 2007 Dec;18(3):202-208.
BACKGROUND: The Korean Red Cross has established three nucleic acid amplification test (NAT) centers, and the organization has begun NAT screening for human immunodeficiency virus type 1 (HIV-1) and hepatitis...
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HIV drug resistance in treatment-naive HIV patients

Oh MD

  • KMID: 2142994
  • Korean J Med.
  • 2007 Sep;73(3):235-236.
Antiretroviral therapy for treatment of human immunodeficiency virus type 1 (HIV-1) infection has improved steadily since the introduction of combination therapy in 1996. With the advancement of antiretroviral therapy, the...
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Studies on the Development of Viral Detection Markers for the Quality Control of Blood

Kim Y, Lee JH, Kim Y

According to the serological screening methods of antigen-antibody reaction such as ELISA, it has been known that the complete detection of viral infections of HBV, HCV, and HIV-1 viruses in...
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Antiretroviral Therapy for Treatment of Human Immunodeficiency Virus Type 1 Infection

Oh MD

It has now been 20 years since the first demonstration that antiretroviral drug, azidothymidine, not only reduce human immunodeficiency virus type 1(HIV-1) replication but also improve clinical outcome. Antiretroviral therapy...
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Extracellular HIV-1 Tat enhances monocyte adhesion by up-regulation of ICAM-1 and VCAM-1 gene expression via ROS-dependent NF-kappaB activation in astrocytes

Song HY, Ryu J, Ju SM, Park LJ, Lee JA, Choi SY, Park J

  • KMID: 1103678
  • Exp Mol Med.
  • 2007 Feb;39(1):27-37.
One of characteristic features of AIDS-related encephalitis and dementia is the infiltration of monocytes into the CNS. HIV-1 Tat was demonstrated to facilitate monocyte entry into the CNS. In this...
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