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Determination of candesartan or olmesartan in hypertensive patient plasma using UPLC-MS/MS

Jeong HC, Seo YH, Gu N, Rhee MY, Shin KH

Candesartan and olmesartan are angiotensin II receptor blockers (ARBs) used for the treatment of hypertension and heart failure. Quantitation methods for candesartan and olmesartan were developed using ultra-high performance liquid...
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Prevalence and characteristics of isolated nocturnal hypertension in the general population

Rhee MY, Kim JS, Kim CH, Kim JH, Lee JH, Kim SW, Nah DY, Gu N, Cho EJ, Sung KC, Hong KS

Background/Aims: Ascertaining the prevalence of isolated nocturnal hypertension (INHT) in the general population and identifying the characteristics of patients with INHT may be important to determine patients who should receive...
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Possibility of pharmacokinetic drug interaction between a DPP-4 inhibitor and a SGLT2 inhibitor

Gu N, Park SI, Chung H, Jin X, Lee S, Kim TE

Type 2 diabetes mellitus is a multifactorial condition characterized by high level of sugar in the blood. To control hyperglycemia, combination therapy is recommended if monotherapy fails to achieve glycemic...
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Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity

Oh J, Yi S, Gu N, Shin D, Yu KS, Yoon SH, Cho JY, Jang IJ

In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials....
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Survey on the undergraduate curriculum in clinical pharmacology and interns' prescribing ability in South Korea

Gu N, Kim KJ, Lim CY, Lee JK, Rhee MY, Shin KH, Lee SH, Ahn S

Appropriate prescription writing is one of the critical medical processes affecting the quality of public health care. However, this is a complex task for newly qualified intern doctors because of...
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Visual Fatigue Induced by Viewing a Tablet Computer with a High-resolution Display

Kim DJ, Lim CY, Gu N, Park CY

PURPOSE: In the present study, the visual discomfort induced by smart mobile devices was assessed in normal and healthy adults. METHODS: Fifty-nine volunteers (age, 38.16 ± 10.23 years; male : female...
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Prevalence of Masked Hypertension: a Population-Based Survey in a Large City by Using 24-Hour Ambulatory Blood Pressure Monitoring

Rhee MY, Kim SW, Choi EH, Kim JH, Nah DY, Shin SJ, Gu N

BACKGROUND AND OBJECTIVES: We estimated the prevalence of hypertension and hypertension subtypes in a large semi-urban city in Korea, using 24-hour ambulatory blood pressure monitoring (ABPM) in a randomly selected...
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Elevation of heart-femoral pulse wave velocity by short-term low sodium diet followed by high sodium diet in hypertensive patients with sodium sensitivity

Rhee MY, Kim JH, Na SH, Chung JW, Bae JH, Nah DY, Gu N, Kim HY

BACKGROUND/OBJECTIVES: We compared changes in heart-femoral pulse wave velocity (hfPWV) in response to low sodium and high sodium diet between individuals with sodium sensitivity (SS) and resistance (SR) to evaluate...
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Influence of Simvastatin on Pharmacokinetics/Pharmacodynamics of Aspirin after Oral Co-administration in Healthy Volunteers

Gu N, Kim BH, Chung YJ, Lim KS, Seo HB, Yim DS, Shin SG, Jang IJ, Yu KS

  • KMID: 2334491
  • J Korean Soc Clin Pharmacol Ther.
  • 2011 Dec;19(2):73-83.
BACKGROUND: Both aspirin and simvastatin are prescribed as treatments or prevention of cardiovascular diseases. The aim of this study was to investigate the influence of simvastatin on pharmacokinetics and pharmacodynamics...
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Ethnic Coefficients for Glomerular Filtration Rate Estimation by the Modification of Diet in Renal Disease Study Equations in the Korean Population

Lee CS, Cha RH, Lim YH, Kim H, Song KH, Gu N, Yu KS, Lim CS, Han JS, Kim S, Kim YS

Race and ethnicity are influential in estimating glomerular filtration rate (GFR). We aimed to find the Korean coefficients for the Modification of Diet in Renal Disease (MDRD) study equations and...
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