- Beta-carotene prevents the spermatogenic disorders induced by exogenous scrotal hyperthermia through modulations of oxidative stress, apoptosis, and androgen biosynthesis in mice
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Yon JM, Kim JS, Lin C, Park SG, Gwon LW, Lee JG, Baek IJ, Nahm SS, Nam SY
- KMID: 2451639
- Korean J Vet Res.
- 2019 Jun;59(2):59-67.
- doi: 10.14405/kjvr.2019.59.2.59
We investigated whether β-carotene (β-CA) or ellagic acid (EA), originating from various fruits and vegetables, has a preventive effect against male infertility induced by exogenous scrotal hyperthermia. ICR adult mice... -
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- Neutrophil-to-lymphocyte ratio independently predicts advanced pathological staging and poorer survival outcomes in testicular cancer
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Tan YG, Sia J, Huang HH, Lau WK
- KMID: 2444272
- Investig Clin Urol.
- 2019 May;60(3):176-183.
- doi: 10.4111/icu.2019.60.3.176
PURPOSE: An elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with adverse outcomes in various malignancies. However, its role in prognosticating testicular cancer (TC) has not been validated. We aim to... -
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- C-Type Natriuretic Peptide/Natriuretic Peptide Receptor 2 Is Involved in Cell Proliferation and Testosterone Production in Mouse Leydig Cells
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Yang L, Lei L, Zhao Q, Gong Y, Guan G, Huang S
- KMID: 2443234
- World J Mens Health.
- 2019 May;37(2):186-198.
- doi: 10.5534/wjmh.180041
PURPOSE: This study investigated the role of natriuretic peptide receptor 2 (NPR2) on cell proliferation and testosterone secretion in mouse Leydig cells. MATERIALS AND METHODS: Mouse testis of different postnatal stages... -
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- Traditional Chinese Medicine as a Remedy for Male Infertility: A Review
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Zhou SH, Deng YF, Weng ZW, Weng HW, Liu ZD
- KMID: 2443233
- World J Mens Health.
- 2019 May;37(2):175-185.
- doi: 10.5534/wjmh.180069
Male infertility (MI) is a complex multifactorial disease, and idiopathic infertility accounts for 30% of cases of MI. At present, the evidence for the effectiveness of empirical drugs is limited,... -
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- Recovery of Spermatogenesis Following Cancer Treatment with Cytotoxic Chemotherapy and Radiotherapy
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Okada K, Fujisawa M
- KMID: 2443232
- World J Mens Health.
- 2019 May;37(2):166-174.
- doi: 10.5534/wjmh.180043
The survival rates of boys and men with cancer have increased due to advances in cancer treatments; however, maintenance of quality of life, including fertility preservation, remains a major issue.... -
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- Effects of paternal age on human embryo development in in vitro fertilization with preimplantation genetic screening
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Kim MK, Park JK, Jeon Y, Seok SH, Chang EM, Lee WS
- KMID: 2469603
- Clin Exp Reprod Med.
- 2019 Mar;46(1):22-29.
- doi: 10.5653/cerm.2019.46.1.22
OBJECTIVE: As paternal age increases, the quality of sperm decreases due to increased DNA fragmentation and aneuploidy. Higher levels of structural chromosomal aberrations in the gametes ultimately decrease both the... -
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- Proboscis lateralis: A case report of a rare giant craniofacial teratoma in an infant
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Al-Shaqsi , Al-Bulushi T, Al-Hinai Q
- KMID: 2427549
- Arch Plast Surg.
- 2018 Nov;45(6):578-582.
- doi: 10.5999/aps.2017.01739
Teratomas can occur in almost any region of the body and are the most common extragonadal germ cell childhood tumors. However, craniofacial teratomas are rare. Craniofacial teratomas can present unique... -
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- Comparative analysis of medical, legal, and ethical considerations for establishing a standard operating protocol for artificial insemination by donor
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Park MJ
- KMID: 2416408
- J Korean Med Assoc.
- 2018 Jul;61(7):383-391.
- doi: 10.5124/jkma.2018.61.7.383
Artificial insemination by donor is an important means of improving the likelihood of pregnancy in couples affected by male factor infertility, but it poses medical, legal, and ethical issues due... -
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- Differentiation of human male germ cells from Wharton's jelly-derived mesenchymal stem cells
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Dissanayake D, Patel H, Wijesinghe P
- KMID: 2415102
- Clin Exp Reprod Med.
- 2018 Jun;45(2):75-81.
- doi: 10.5653/cerm.2018.45.2.75
OBJECTIVE: Recapitulation of the spermatogenesis process in vitro is a tool for studying the biology of germ cells, and may lead to promising therapeutic strategies in the future. In this... -
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- Intracranial Germ Cell Tumor in the Molecular Era
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Phi JH, Wang KC, Kim SK
- KMID: 2417358
- J Korean Neurosurg Soc.
- 2018 May;61(3):333-342.
- doi: 10.3340/jkns.2018.0056
Intracranial germ cell tumors (iGCTs) are a heterogeneous group of tumors with peculiar characteristics clearly distinguished from other brain tumors of neuroepithelial origin. Diverse histology, similarity to gonadal GCT, predilection... -
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- Variable localization of Toll-like receptors in human fallopian tube epithelial cells
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Amjadi F, Zandieh Z, Salehi E, Jafari R, Ghasemi N, Aflatoonian A, Fazeli A, Aflatoonian R
- KMID: 2408570
- Clin Exp Reprod Med.
- 2018 Mar;45(1):1-9.
- doi: 10.5653/cerm.2018.45.1.1
OBJECTIVE: To determine the localization, expression, and function of Toll-like receptors (TLRs) in fallopian tube epithelial cells. METHODS: The localization of TLRs in fallopian tube epithelial cells was investigated by immunostaining.... -
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- Fertility preservation for patients with hematologic malignancies: The Korean Society for Fertility Preservation clinical guidelines
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Lee DY, Kim SK, Kim M, Hwang KJ, Kim SH
- KMID: 2401620
- Clin Exp Reprod Med.
- 2017 Dec;44(4):187-192.
- doi: 10.5653/cerm.2017.44.4.187
Although the survival rate of hematologic malignancies in young patients is very high, cytotoxic therapies such as chemotherapy and total body irradiation therapy can significantly reduce a patient's reproductive capacity... -
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- Application of stereological methods for unbiased estimation of sperm morphology in the mice induced by busulfan
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Panahi S, Abdollahifar MA, Aliaghaei , Nazarian H, Paktinat S, Abdi S, Farahani R
- KMID: 2399899
- Anat Cell Biol.
- 2017 Dec;50(4):301-305.
- doi: 10.5115/acb.2017.50.4.301
Busulfan is an anticancer drug, which causes the apoptosis germ cells and azoospermia in humans and animals. Abnormal morphology of spermatozoa related to the male infertility. The sperm morphology is... -
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- Enrichment and In Vitro Culture of Spermatogonial Stem Cells from Pre-Pubertal Monkey Testes
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Kim YH, Kang HG, Kim BJ, Jung SE, Karmakar P, Kim SM, Hwang S, Ryu BY
- KMID: 2394989
- Tissue Eng Regen Med.
- 2017 Oct;14(5):557-566.
- doi: 10.1007/s13770-017-0058-x
Spermatogonial stem cells (SSCs) are essential for spermatogenesis throughout the lifespan of the male. However, the rarity of SSCs has raised the need for an efficient selection method, but little... -
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- Neurocognitive and Psychological Functioning of Children with an Intracranial Germ Cell Tumor
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Park Y, Yu ES, Ha B, Park HJ, Kim JH, Kim JY
- KMID: 2394815
- Cancer Res Treat.
- 2017 Oct;49(4):960-969.
- doi: 10.4143/crt.2016.204
PURPOSE: This study was conducted to investigate the neurocognitive functioning of children with intracranial germ cell tumor (IGCT) prior to receiving proton beam therapy (PBT), and to identify differential characteristics... -
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- Dose-dependent effects of busulfan on dog testes in preparation for spermatogonial stem cell transplantation
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Hur TY, Lee SH, Ock SA, Song H, Park HJ, Lee R, Sung SH, Jhun H, Lee WY
- KMID: 2391101
- Lab Anim Res.
- 2017 Sep;33(3):264-269.
- doi: 10.5625/lar.2017.33.3.264
Successful male germ cell transplantation requires depletion of the host germ cells to allow efficient colonization of the donor spermatogonial stem cells. Although a sterilizing drug, busulfan, is commonly used... -
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- Role of Antioxidants in Assisted Reproductive Techniques
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Agarwal A, Majzoub A
- KMID: 2388443
- World J Mens Health.
- 2017 Aug;35(2):77-93.
- doi: 10.5534/wjmh.2017.35.2.77
Oxidative stress (OS) has been recognized as a significant cause of suboptimal assisted reproductive outcome. Many of the sperm preparation and manipulation procedures that are necessary in the in vitro... -
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- Gut Microbiota and Metabolic Disorders
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Hur KY
- KMID: 2385566
- J Korean Diabetes.
- 2017 Jun;18(2):63-70.
- doi: 10.4093/jkd.2017.18.2.63
The adult gut microbiota comprises 10~100 trillion microorganisms, which is equivalent to 10 times the number of total somatic and germ cells. Further, the collective genomes of gut microbiota (microbiome)... -
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- Histone lysine demethylases in mammalian embryonic development
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Shen H, Xu W, Lan F
- KMID: 2382716
- Exp Mol Med.
- 2017 Apr;49(4):e325.
- doi: 10.1038/emm.2017.57
Post-translational modifications, such as methylation, acetylation and phosphorylation, of histone proteins play important roles in regulating dynamic chromatin structure. Histone demethylation has become one of the most active research areas... -
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- Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012
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Lee SH, Jung KW, Ha J, Oh CM, Kim H, Park HJ, Yoo H, Won YJ
- KMID: 2378122
- Cancer Res Treat.
- 2017 Apr;49(2):494-501.
- doi: 10.4143/crt.2016.129
PURPOSE: Malignant central nervous system (CNS) germ cell tumors (GCTs), although rare, are thought to occur more frequently among Asians. However, a recent population-based study revealed no differences in GCT... -
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