- Editor’s Introduction to This Issue (G&I 15:4, 2017)
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Chung YJ
- KMID: 2404046
- Genomics Inform.
- 2017 Dec;15(4):113-113.
- doi: 10.5808/GI.2017.15.4.113
No abstract available. -
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- CTCF, Cohesin, and Chromatin in Human Cancer
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Song SH, Kim TY
- KMID: 2404047
- Genomics Inform.
- 2017 Dec;15(4):114-122.
- doi: 10.5808/GI.2017.15.4.114
It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene... -
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- Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model
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Kumar S
- KMID: 2404054
- Genomics Inform.
- 2017 Dec;15(4):162-169.
- doi: 10.5808/GI.2017.15.4.162
Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis.... -
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- IVAG: An Integrative Visualization Application for Various Types of Genomic Data Based on R-Shiny and the Docker Platform
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Lee TR, Ahn JM, Kim G, Kim S
- KMID: 2404056
- Genomics Inform.
- 2017 Dec;15(4):178-182.
- doi: 10.5808/GI.2017.15.4.178
Next-generation sequencing (NGS) technology has become a trend in the genomics research area. There are many software programs and automated pipelines to analyze NGS data, which can ease the pain... -
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- misMM: An Integrated Pipeline for Misassembly Detection Using Genotyping-by-Sequencing and Its Validation with BAC End Library Sequences and Gene Synteny
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Ko YJ, Kim JS, Kim S
- KMID: 2404049
- Genomics Inform.
- 2017 Dec;15(4):128-135.
- doi: 10.5808/GI.2017.15.4.128
As next-generation sequencing technologies have advanced, enormous amounts of whole-genome sequence information in various species have been released. However, it is still difficult to assemble the whole genome precisely, due... -
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- HOTAIR Long Non-coding RNA: Characterizing the Locus Features by the In Silico Approaches
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Hajjari M, Rahnama S
- KMID: 2404055
- Genomics Inform.
- 2017 Dec;15(4):170-177.
- doi: 10.5808/GI.2017.15.4.170
HOTAIR is an lncRNA that has been known to have an oncogenic role in different cancers. There is limited knowledge of genetic and epigenetic elements and their interactions for the... -
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- Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking
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Lee IW, Yoon J, Lee G, Lee M
- KMID: 2404052
- Genomics Inform.
- 2017 Dec;15(4):147-155.
- doi: 10.5808/GI.2017.15.4.147
Apurinic/apyrimidinic endonuclease 1 (APE1) is an enzyme responsible for the initial step in the base excision repair pathway and is known to be a potential drug target for treating cancers,... -
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- Classification of Genes Based on Age-Related Differential Expression in Breast Cancer
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Lee G, Lee M
- KMID: 2404053
- Genomics Inform.
- 2017 Dec;15(4):156-161.
- doi: 10.5808/GI.2017.15.4.156
Transcriptome analysis has been widely used to make biomarker panels to diagnose cancers. In breast cancer, the age of the patient has been known to be associated with clinical features.... -
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- Synonymous Codon Usage Controls Various Molecular Aspects
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Im EH, Choi SS
- KMID: 2404048
- Genomics Inform.
- 2017 Dec;15(4):123-127.
- doi: 10.5808/GI.2017.15.4.123
Synonymous sites are generally considered to be functionally neutral. However, there are recent contradictory findings suggesting that synonymous alleles might have functional roles in various molecular aspects. For instance, a... -
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- Structural Analysis of Recombinant Human Preproinsulins by Structure Prediction, Molecular Dynamics, and Protein-Protein Docking
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Jung SH, Kim CK, Lee G, Yoon J, Lee M
- KMID: 2404051
- Genomics Inform.
- 2017 Dec;15(4):142-146.
- doi: 10.5808/GI.2017.15.4.142
More effective production of human insulin is important, because insulin is the main medication that is used to treat multiple types of diabetes and because many people are suffering from... -
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- Validation of Customized Cancer Panel for Detecting Somatic Mutations and Copy Number Alterations
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Choi SH, Jung SH, Chung YJ
- KMID: 2404050
- Genomics Inform.
- 2017 Dec;15(4):136-141.
- doi: 10.5808/GI.2017.15.4.136
Accurate detection of genomic alterations, especially druggable hotspot mutations in tumors, has become an essential part of precision medicine. With targeted sequencing, we can obtain deeper coverage of reads and... -
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