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Editor's Introduction to This Issue

Chung YJ

No abstract available.
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ERRATUM: Acknowledgments Correction. Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer

Park JL, Kim M, Song KS, Kim SY, Kim YS

The funding acknowledgment in this article was partially omitted as published.
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Analysis of Whole Transcriptome Sequencing Data: Workflow and Software

Yang IS, Kim S

RNA is a polymeric molecule implicated in various biological processes, such as the coding, decoding, regulation, and expression of genes. Numerous studies have examined RNA features using whole transcriptome sequencing...
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Building the Frequency Profile of the Core Promoter Element Patterns in the Three ChromHMM Promoter States at 200bp Intervals: A Statistical Perspective

Lent H, Lee KE, Park HS

Recently, the Encyclopedia of DNA Elements (ENCODE) Analysis Working Group converted data from ChIP-seq analyses from the Broad Histone track into 15 corresponding chromatic maps that label sequences with different...
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Introns: The Functional Benefits of Introns in Genomes

Jo BS, Choi SS

The intron has been a big biological mystery since it was first discovered in several aspects. First, all of the completely sequenced eukaryotes harbor introns in the genomic structure, whereas...
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Heritability Estimated Using 50K SNPs Indicates Missing Heritability Problem in Holstein Breeding

Shin D, Park KD, Ka S, Kim H, Cho KH

Previous studies in Holstein have shown 35% to 51.8% heritability in milk production traits, such as milk yield, fat, and protein, using pedigree data. Other studies in complex human traits...
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Role of Chromosome Changes in Crocodylus Evolution and Diversity

Srikulnath K, Thapana W, Muangmai N

The karyotypes of most species of crocodilians were studied using conventional and molecular cytogenetics. These provided an important contribution of chromosomal rearrangements for the evolutionary processes of Crocodylia and Sauropsida...
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Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

Fu Y, Lee I, Lee YS, Bao X

tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs...
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Expressional Subpopulation of Cancers Determined by G64, a Co-regulated Module

Min JW, Choi SS

Studies of cancer heterogeneity have received considerable attention recently, because the presence or absence of resistant sub-clones may determine whether or not certain therapeutic treatments are effective. Previously, we have...
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Prediction of Genes Related to Positive Selection Using Whole-Genome Resequencing in Three Commercial Pig Breeds

Kim H, Caetano-Anolles K, Seo M, Kwon YJ, Cho S, Seo K, Kim H

Selective sweep can cause genetic differentiation across populations, which allows for the identification of possible causative regions/genes underlying important traits. The pig has experienced a long history of allele frequency...
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Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans

Kwak SH, Kim YJ, Chae J, Lee CH, Han B, Kim JI, Jung HS, Cho YM, Park KS

Fulminant type 1 diabetes (T1DM) is a distinct subtype of T1DM that is characterized by rapid onset hyperglycemia, ketoacidosis, absolute insulin deficiency, and near normal levels of glycated hemoglobin at...
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