- Analysis of unmapped regions associated with long deletions in Korean whole genome sequences based on short read data
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Lee Y, Park K, Koh I
- KMID: 2468866
- Genomics Inform.
- 2019 Dec;17(4):e40.
- doi: 10.5808/GI.2019.17.4.e40
While studies aimed at detecting and analyzing indels or single nucleotide polymorphisms within human genomic sequences have been actively conducted, studies on detecting long insertions/deletions are not easy to orchestrate.... -
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- Genetic and epigenetic alterations of colorectal cancer
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Hong SN
- KMID: 2417644
- Intest Res.
- 2018 Jul;16(3):327-337.
- doi: 10.5217/ir.2018.16.3.327
Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing... -
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- Molecular Signature for Lymphatic Invasion Associated with Survival of Epithelial Ovarian Cancer
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Paik ES, Choi HJ, Kim TJ, Lee JW, Kim BG, Bae DS, Choi CH
- KMID: 2411135
- Cancer Res Treat.
- 2018 Apr;50(2):461-473.
- doi: 10.4143/crt.2017.104
PURPOSE: We aimed to develop molecular classifier that can predict lymphatic invasion and their clinical significance in epithelial ovarian cancer (EOC) patients. MATERIALS AND METHODS: We analyzed gene expression (mRNA, methylated... -
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- The Future Medical Science and Colorectal Surgeons
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Kim YJ
- KMID: 2439836
- Ann Coloproctol.
- 2017 Dec;33(6):207-209.
- doi: 10.3393/ac.2017.33.6.207
Future medical technology breakthroughs will build from the incredible progress made in computers, biotechnology, and nanotechnology and from the information learned from the human genome. With such technology and information,... -
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- Gut Microbiota and Metabolic Disorders
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Hur KY
- KMID: 2385566
- J Korean Diabetes.
- 2017 Jun;18(2):63-70.
- doi: 10.4093/jkd.2017.18.2.63
The adult gut microbiota comprises 10~100 trillion microorganisms, which is equivalent to 10 times the number of total somatic and germ cells. Further, the collective genomes of gut microbiota (microbiome)... -
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- National human genome projects: an update and an agenda
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An JY
- KMID: 2406649
- Epidemiol Health.
- 2017;39:e2017045.
- doi: 10.4178/epih.e2017045
Population genetic and human genetic studies are being accelerated with genome technology and data sharing. Accordingly, in the past 10 years, several countries have initiated genetic research using genome technology... -
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- Mining the Proteome of Fusobacterium nucleatum subsp. nucleatum ATCC 25586 for Potential Therapeutics Discovery: An In Silico Approach
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Habib AM, Islam MS, Sohel M, Mazumder M, Sikder MO, Shahik SM
- KMID: 2366444
- Genomics Inform.
- 2016 Dec;14(4):255-264.
- doi: 10.5808/GI.2016.14.4.255
The plethora of genome sequence information of bacteria in recent times has ushered in many novel strategies for antibacterial drug discovery and facilitated medical science to take up the challenge... -
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- Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition
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Kim SA, Yoo YJ
- KMID: 2366436
- Genomics Inform.
- 2016 Dec;14(4):196-204.
- doi: 10.5808/GI.2016.14.4.196
Many researchers have found that one of the most important characteristics of the structure of linkage disequilibrium is that the human genome can be divided into non-overlapping block partitions in... -
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- Trends in Next-Generation Sequencing and a New Era for Whole Genome Sequencing
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Park ST, Kim J
- KMID: 2362500
- Int Neurourol J.
- 2016 Nov;20(Suppl 2):S76-S83.
- doi: 10.5213/inj.1632742.371
This article is a mini-review that provides a general overview for next-generation sequencing (NGS) and introduces one of the most popular NGS applications, whole genome sequencing (WGS), developed from the... -
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- Structural Variation of Alu Element and Human Disease
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Kim S, Cho CS, Han K, Lee J
- KMID: 2353657
- Genomics Inform.
- 2016 Sep;14(3):70-77.
- doi: 10.5808/GI.2016.14.3.70
Transposable elements are one of major sources to cause genomic instability through various mechanisms including de novo insertion, insertion-mediated genomic deletion, and recombination-associated genomic deletion. Among them is Alu element... -
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- Aberrant Expression of Breast Development-Related MicroRNAs, miR-22, miR-132, and miR-212, in Breast Tumor Tissues
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Damavandi , Torkashvand S, Vasei M, Soltani BM, Tavallaei , Mowla SJ
- KMID: 2308965
- J Breast Cancer.
- 2016 Jun;19(2):148-155.
- doi: 10.4048/jbc.2016.19.2.148
PURPOSE: MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that posttranscriptionally regulate the expression of most genes in the human genome. miRNAs are often located in chromosomal... -
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- Epigenetic modification of long interspersed elements-1 in cumulus cells of mature and immature oocytes from patients with polycystic ovary syndrome
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Pruksananonda K, Wasinarom , Sereepapong W, Sirayapiwat P, Rattanatanyong P, Mutirangura A
- KMID: 2308893
- Clin Exp Reprod Med.
- 2016 Jun;43(2):82-89.
- doi: 10.5653/cerm.2016.43.2.82
OBJECTIVE: The long interspersed elements (LINE-1, L1s) are a group of genetic elements found in large numbers in the human genome that can translate into phenotype by controlling genes. Growing... -
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- Recent Advances in Autism Spectrum Disorders: Applications of Whole Exome Sequencing Technology
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Sener EF, Canatan H, Ozkul Y
- KMID: 2316642
- Psychiatry Investig.
- 2016 May;13(3):255-264.
- doi: 10.4306/pi.2016.13.3.255
Autism spectrum disorders (ASD) is characterized by three core symptoms with impaired reciprocal social interaction and communication, a pattern of repetitive behavior and/or restricted interests in early childhood. The prevalence... -
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- Thyroid Cancer: We Need a Carcinogen-specific Genome Study
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Bae JM
- KMID: 2359981
- J Korean Med Sci.
- 2015 Dec;30(12):1920-1921.
- doi: 10.3346/jkms.2015.30.12.1920
No abstract available. -
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- Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting
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Kim MS, Lee JR, Choi EM, Kim EH, Choi SH
- KMID: 2163638
- Yonsei Med J.
- 2015 Sep;56(5):1415-1420.
- doi: 10.3349/ymj.2015.56.5.1415
PURPOSE: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with... -
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- A Novel Case of Extreme Thrombocytosis in Acute Myeloid Leukemia Associated With Isochromosome 17q and Copy Neutral Loss of Heterozygosity
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You E, Cho SY, Yang JJ, Lee HJ, Lee WI, Lee J, Cho KS, Cho EH, Park TS
- KMID: 2363212
- Ann Lab Med.
- 2015 May;35(3):366-369.
- doi: 10.3343/alm.2015.35.3.366
No abstract available. -
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- Genome Architecture and Its Roles in Human Copy Number Variation
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Chen L, Zhou W, Zhang L, Zhang F
- KMID: 2391488
- Genomics Inform.
- 2014 Dec;12(4):136-144.
- doi: 10.5808/GI.2014.12.4.136
Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic... -
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- Systems biology approaches in asthma pharmacogenomics study
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Park HW
- KMID: 1803538
- Allergy Asthma Respir Dis.
- 2014 Nov;2(5):326-331.
- doi: 10.4168/aard.2014.2.5.326
The response to drug treatment in asthma is a complex trait and is markedly variable even in patients with apparently similar clinical features. Pharmacogenomics is a study of variations of... -
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- Overgrowth Syndrome with 9q22.3 Microdeletion Detected by Microarray Comparative Genomic Hybridization
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Park YJ, Park SB, Kim SM, Chae YJ, Kim JD, Jung CL
- KMID: 1802887
- Neonatal Med.
- 2014 Nov;21(4):264-269.
- doi: 10.5385/nm.2014.21.4.264
Microdeletion of 9q22.3 is a rare chromosomal disorder characterized by body overgrowth, facial dysmorphic features and psychomotor delay. The presence of genomic microdeletion or microdu-plication can not be identified by... -
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- Next Generation DNA Sequencing and Its Application in Clinical Medicine
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Cho S
- KMID: 2280986
- Korean J Perinatol.
- 2014 Sep;25(3):133-139.
- doi: 10.14734/kjp.2014.25.3.133
Watson and Crick published a paper on the double helical structure of DNA in Nature in April 25, 1953. The human genome is contained in the 23 pairs of chromosomes... -
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