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Animal models of heart failure and new molecular strategy for the treatment of heart failure

Cho MC

  • KMID: 2305879
  • Korean J Med.
  • 2008 Jan;74(1):4-15.
Heart failure (HF) is a complex condition in which multiple molecular mechanisms interact, resulting in compromised cardiac function and often death. Despite the benefits of current therapies including ACE inhibitors...
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Book Review: The Case Against Perfection

Ha JH

No abstract available.
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Pathophysiology of Aneurysmal Subarachnoid Hemorrhage

Sung JH, Lee SW

  • KMID: 1932130
  • Korean J Cerebrovasc Surg.
  • 2003 Mar;5(1):17-30.
The effects of an intracranial aneurysm and subarachnoid hemorrhage (SAH) are devastating. Therefore thorough consideration for pathophysiology of SAH is fundamental step of vascular neurosurgeon. The cigarette smoking and hypertension...
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Genome Editing Using Engineered Nucleases

Shin JH, Kim H

Genome editing is a useful research tool essentially applicable to gene therapy in the field of biotechnology, pharmaceutics and medicine. Scientists have developed three types of programmable nucleases for genome...
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Mouse Models of Gastric Carcinogenesis

Yu S, Yang M, Nam KT

  • KMID: 2372515
  • J Gastric Cancer.
  • 2014 Jun;14(2):67-86.
Gastric cancer is one of the most common cancers in the world. Animal models have been used to elucidate the details of the molecular mechanisms of various cancers. However, most...
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Cryopreservation of Oocytes and Embryos by Vitrification

Gupta MK, Lee HT

  • KMID: 1458325
  • Korean J Reprod Med.
  • 2010 Dec;37(4):267-291.
Life can be kept in suspended animation either before fertilization at oocyte stage or after fertilization at different stages of embryonic development for a variety of reasons. It not only...
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Tumor Therapy Applying Membrane-bound Form of Cytokines

Kim YS

Tumor therapy using cytokines has been developed for last two decades. Several recombinant cytokines and tumor cell vaccines produced by cytokine gene transfer have been in clinical trials, but several...
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In vitro generation of mature midbrain-type dopamine neurons by adjusting exogenous Nurr1 and Foxa2 expressions to their physiologic patterns

Kim T, Song JJ, Puspita L, Valiulahi , Shim JW, Lee SH

Developmental information aids stem cell biologists in producing tissue-specific cells. Recapitulation of the developmental profile of a specific cell type in an in vitro stem cell system provides a strategy...
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Applications of CRISPR/Cas9 for Gene Editing in Hereditary Movement Disorders

Im W, Moon J, Kim M

Gene therapy is a potential therapeutic strategy for treating hereditary movement disorders, including hereditary ataxia, dystonia, Huntington's disease, and Parkinson's disease. Genome editing is a type of genetic engineering in...
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Genetically Engineered In Vitro Erythropoiesis

Geiler C, Andrade I, Clayton A, Greenwald

BACKGROUND: Engineered blood has the greatest potential to combat a predicted future shortfall in the US blood supply for transfusion treatments. Engineered blood produced from hematopoietic stem cell (HSC) derived...
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Targeted Cancer Therapy Using Engineered Salmonella typhimurium

Zheng JH, Min JJ

Obligate or facultative anaerobic bacteria such as Bifidobacterium, Clostridium, Salmonella, or Escherichia coli specifically colonize and proliferate inside tumor tissues and inhibit tumor growth. Among them, attenuated Salmonella typhimurium (S....
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Brain Tumor Immunology: Part II : Immunotherapy of Malignant Brain Tumors

Hong YK, Rha HK, Jung CK, Lee SW, Jo TH, Baik MW, Yoon SH, Kang JK, Song JU, Choi CR

  • KMID: 2067857
  • J Korean Neurosurg Soc.
  • 1990 Dec;19(10-12):1389-1396.
The prognosis of patients with malignant brain tumors has improved only slightly despite the combined use of surgery, radiation therapy, and chemotherapy. Immunotherapy offers some possibilities and hopes as a...
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Retroviral Vector-mediated Interleukin-2 Gene Transfer into Human Renal Cell Carcinoma Cell Line

Chung BH, Lee DH, Hong SJ

  • KMID: 1884658
  • Korean J Urol.
  • 1998 May;39(5):418-422.
PURPOSE: The therapeutic dose of cytokine for patients with advanced renal cell carcinoma is very high and leads to toxic side effects and a substantial cost to the patients....
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Effects of Several Herbal Medicines on Alkaline Phosphatase Activity in Human Fetal Osteoblasts

Lee MK, Choi HI, You HK, Shin HS

Several growth factors and polypeptides are not commonly yet used for regenerators of bone tissue or alveolar bone because of the insufficiency of studies on their side effects, genetic engineering...
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Affinity Improvement of Antibody-Avidin Fusion Proteins for Biotin

Cho MY, Kim HJ, Cho HM, Shin SU

  • KMID: 1557240
  • Korean J Immunol.
  • 1998 Dec;20(4):381-388.
To generate drug delivery vector to locales in the body, genetic engineering and expression techniques have been used to produce antibody avidin fusion proteins. Chicken avidin has been fused to...
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Current Status and Future Perspectives of Xenotransplantation and Stem Cell Research in Transplantation Field

Park CG, Kim JS, Kim YH

The severe shortage of human organ donors is one of the biggest problems with organ transplantation. The solution for this problem would be development of artificial organs or mechanical devices,...
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Medaka Fish Parkinson's Disease Model

Matsui H, Gavinio R, Takahashi

The teleost fish has been widely used in creating neurodegenerative models. Here we describe the teleost medaka fish Parkinson's disease (PD) models we developed using toxin treatment and genetic engineering....
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Enhanced protective immune response to PCV2 adenovirus vaccine by fusion expression of Cap protein with InvC in pigs

Zhang Z, Luo Y, Zhang Y, Guo K

The major immunogenic protein capsid (Cap) of porcine circovirus type 2 (PCV2) is critical to induce neutralizing antibodies and protective immune response against PCV2 infection. This study was conducted to...
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Salmonella-Mediated Cancer Therapy: Roles and Potential

Nguyen VH, Min JJ

The use of bacteria for cancer therapy, which was proposed many years ago, was not recognized as a potential therapeutic strategy until recently. Technological advances and updated knowledge have enabled...
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Nuclear Medicine in Oncology

Choi CW

Nuclear oncolgy is important in the diagnosis, staging, and long-term surveillance of a number of cancers. Over the past 10 years there has been an explosion of new radioisotopic tracers...
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