- Combined biomarker for prediction of response to an immune checkpoint inhibitor in metastatic gastric cancer
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Heo YJ, Kang SY, Kim ST, Kang WK, Lee J, Kim KM
- KMID: 2470437
- Precis Future Med.
- 2019 Dec;3(4):165-175.
- doi: 10.23838/pfm.2019.00079
PURPOSE: Immune checkpoint blockades (ICB) have been successful in gastric cancer (GC). However, the majority of unselected patients with GC fail to respond to ICB. It is crucial to identify... -
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- TarGo: network based target gene selection system for human disease related mouse models
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Hyung D, Mallon AM, Kyung DS, Cho SY, Seong JK
- KMID: 2470013
- Lab Anim Res.
- 2019 Dec;35(4):165-171.
- doi: 10.1186/s42826-019-0023-z
Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with detectable phenotypes are... -
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- Analysis of Intestinal Mucosal Microbiome Changes before and after Chemoradiation in Locally Advanced Rectal Cancer Patients
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Seo I, Bae SU, Kim S, Jeong WK, Baek SK
- KMID: 2468023
- J Bacteriol Virol.
- 2019 Dec;49(4):162-175.
- doi: 10.4167/jbv.2019.49.4.162
PURPOSE: Dysbiosis of gut microbiota has been reported to participate in the pathogenesis of colorectal cancer, but changes in microbiota due to radiotherapy have not been studied. In this study,... -
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- Prediction of Chemotherapy-Induced Peripheral Neuropathy in Patients with Lymphoma and Myeloma: the Roles of Brain-Derived Neurotropic Factor Protein Levels and A Gene Polymorphism
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Azoulay D, Giryes S, Nasser R, Sharon R, Horowitz N
- KMID: 2467761
- J Clin Neurol.
- 2019 Oct;15(4):511-516.
- doi: 10.3988/jcn.2019.15.4.511
BACKGROUND AND PURPOSE: Brain-derived neurotrophic factor (BDNF) is a neuronal growth factor that plays an essential role in the maintenance of the nervous system. We have evaluated the peripheral blood... -
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- A Case of 47-Years-Old Female with Obstructive Jaundice and Weight Loss
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Park PG, Kang H, Chung MJ, Park JY, Bang S, Park SW, Song SY, Lee HS
- KMID: 2455390
- J Dig Cancer Res.
- 2019 Jun;7(1):18-21.
- doi: 10.0000/jdcr.2019.7.1.18
Serine protease inhibitor Kazal-type 1 (SPINK1) is a gene expressed from pancreatic acinar cell which its mutation is known to be associated with chronic pancreatitis (CP) and pancreatic cancer. We... -
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- Bleomycin Inhibits Proliferation via Schlafen-Mediated Cell Cycle Arrest in Mouse Alveolar Epithelial Cells
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Jang S, Ryu SM, Lee J, Lee H, Hong SH, Ha KS, Park WS, Han ET, Yang SR
- KMID: 2453983
- Tuberc Respir Dis.
- 2019 Apr;82(2):133-142.
- doi: 10.4046/trd.2017.0124
BACKGROUND: Idiopathic pulmonary fibrosis involves irreversible alveolar destruction. Although alveolar epithelial type II cells are key functional participants within the lung parenchyma, how epithelial cells are affected upon bleomycin (BLM)... -
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- Rab GTPases as Physiological Substrates of LRRK2 Kinase
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Seol W, Nam D, Son I
- KMID: 2450209
- Exp Neurobiol.
- 2019 Apr;28(2):134-145.
- doi: 10.5607/en.2019.28.2.134
LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 harbors GTPase and kinase activities, two enzyme activities... -
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- Distribution of Rickettsia spp. in Ticks from Northwestern and Southwestern Provinces, Republic of Korea
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Jiang J, Choi YJ, Kim J, Kim HC, Klein TA, Chong ST, Richards A, Park HJ, Shin SH, Song D, Park KH, Jang WJ
- KMID: 2448147
- Korean J Parasitol.
- 2019 Apr;57(2):161-166.
- doi: 10.3347/kjp.2019.57.2.161
This study was done to characterize distribution of Rickettsia spp. in ticks in the northwestern and southwestern provinces in the Republic of Korea. A total of 2,814 ticks were collected... -
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- von Willebrand Factor Gene Expression in Primary Lower Grade Glioma: Mutually Co-Occurring Mutations in von Willebrand Factor, ATRX, and TP53
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Lehrer S, Rheinstein PH, Green S, Rosenzweig KE
- KMID: 2444793
- Brain Tumor Res Treat.
- 2019 Apr;7(1):33-38.
- doi: 10.14791/btrt.2019.7.e20
BACKGROUND: Venous thromboembolism is a common complication in patients with glioma. The clotting factor von Willebrand factor (VWF) is a highly adhesive procoagulant molecule that mediates platelet adhesion to endothelial... -
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- Cis-AB, the Blood Group of Many Faces, Is a Conundrum to the Novice Eye
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Chun S, Choi S, Yu H, Cho D
- KMID: 2425965
- Ann Lab Med.
- 2019 Mar;39(2):115-120.
- doi: 10.3343/alm.2019.39.2.115
Cis-AB, a rare ABO variant, is caused by a gene mutation that results in a single glycosyltransferase enzyme with dual A and B glycosyltransferase activities. It is the most frequent... -
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- Complete Sequence of the Mitochondrial Genome of Spirometra ranarum: Comparison with S. erinaceieuropaei and S. decipiens
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Jeon HK, Park H, Lee D, Choe S, Kang Y, Bia MM, Lee SH, Eom KS
- KMID: 2441608
- Korean J Parasitol.
- 2019 Feb;57(1):55-60.
- doi: 10.3347/kjp.2019.57.1.55
This study was undertaken to determine the complete mitochondrial DNA sequence and structure of the mitochondrial genome of Spirometra ranarum, and to compare it with those of S. erinaceieuropaei and... -
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- STADIUM: Species-Specific tRNA Adaptive Index Compendium
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Yoon J, Chung YJ, Lee M
- KMID: 2439218
- Genomics Inform.
- 2018 Dec;16(4):e28.
- doi: 10.5808/GI.2018.16.4.e28
Due to the increasing interest in synonymous codons, several codon bias-related terms were introduced. As one measure of them, the tRNA adaptation index (tAI) was invented about a decade ago.... -
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- Genetic Hearing Loss and Gene Therapy
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Carpena NT, Lee MY
- KMID: 2439210
- Genomics Inform.
- 2018 Dec;16(4):e20.
- doi: 10.5808/GI.2018.16.4.e20
Genetic hearing loss crosses almost all the categories of hearing loss which includes the following: conductive, sensory, and neural; syndromic and nonsyndromic; congenital, progressive, and adult onset; high-frequency, low-frequency, or... -
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- Ophthalmoplegia in Mitochondrial Disease
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Lee SJ, Na JH, Han J, Lee YM
- KMID: 2426333
- Yonsei Med J.
- 2018 Dec;59(10):1190-1196.
- doi: 10.3349/ymj.2018.59.10.1190
PURPOSE: To evaluate the classification, diagnosis, and natural course of ophthalmoplegia associated with mitochondrial disease. MATERIALS AND METHODS: Among 372 patients with mitochondrial disease who visited our hospital between January 2006... -
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- Molecular and Biochemical Properties of a Cysteine Protease of Acanthamoeba castellanii
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Hong Y, Kang JM, Joo SY, Song SM, Lê HG, Thái TL, Lee J, Goo YK, Chung DI, Sohn WM, Na BK
- KMID: 2426745
- Korean J Parasitol.
- 2018 Oct;56(5):409-418.
- doi: 10.3347/kjp.2018.56.5.409
Acanthamoeba spp. are free-living protozoa that are opportunistic pathogens for humans. Cysteine proteases of Acanthamoeba have been partially characterized, but their biochemical and functional properties are not clearly understood yet.... -
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- CCR6 Is a Predicting Biomarker of Radiosensitivity and Potential Target of Radiosensitization in Rectal Cancer
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Chang H, Wei JW, Tao YL, Ding PR, Xia YF, Gao YH, Xiao WW
- KMID: 2424793
- Cancer Res Treat.
- 2018 Oct;50(4):1203-1213.
- doi: 10.4143/crt.2017.538
PURPOSE: This study aimed to explore the functions and mechanisms of C-C motif chemokine receptor 6 (CCR6), a gene associated with progression and metastasis of colorectal cancer (CRC), in radiosensitivity... -
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- Exploring the Key Genes and Pathways of Osteoarthritis in Knee Cartilage in a Rat Model Using Gene Expression Profiling
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Ren YM, Zhao X, Yang T, Duan YH, Sun YB, Zhao WJ, Tian MQ
- KMID: 2415535
- Yonsei Med J.
- 2018 Aug;59(6):760-768.
- doi: 10.3349/ymj.2018.59.6.760
PURPOSE: To compare differentially expressed genes (DEGs) mediating osteoarthritis (OA) in knee cartilage and in normal knee cartilage in a rat model of OA and to identify their impact on... -
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- Genetic and Morphologic Identification of Spirometra ranarum in Myanmar
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Jeon HK, Park H, Lee D, Choe S, Kang Y, Bia MM, Lee SH, Sohn WM, Hong SJ, Chai JY, Eom KS
- KMID: 2416358
- Korean J Parasitol.
- 2018 Jun;56(3):275-280.
- doi: 10.3347/kjp.2018.56.3.275
In the present study, we identified a Spirometra species of Myanmar origin (plerocercoid) by molecular analysis using mitochondrial cox1 and nad1 genes, as well as by morphological observations of an... -
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- A two-component signal transduction system contributes to the virulence of Riemerella anatipestifer
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Wang Q, Chen M, Zhang W
- KMID: 2407625
- J Vet Sci.
- 2018 Mar;19(2):260-270.
- doi: 10.4142/jvs.2018.19.2.260
Similar to other studies of bacterial pathogens, current studies of the pathogenesis of Riemerella anatipestifer (RA) are focused mainly on in vitro culture conditions. To elucidate further the pathogenesis of... -
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- A gene expression signature of FOXM1 predicts the prognosis of hepatocellular carcinoma
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Song BN, Chu IS
- KMID: 2438348
- Exp Mol Med.
- 2018 Jan;50(1):e418.
- doi: 10.1038/emm.2017.159
FOXM1 (Forkhead box M1) is a key regulator of tumorigenesis. Previous studies demonstrated that FOXM1 overexpression was strongly correlated with poor prognosis in various cancers, including hepatocellular carcinoma (HCC). In... -
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