- Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis
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Lee KH, Lim JH, Kim JH
- KMID: 1806269
- Genomics Inform.
- 2013 Mar;11(1):38-45.
- doi: 10.5808/GI.2013.11.1.38
In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes... -
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- Early Onset Renal Failure in Congenital Nephrotic Syndrome associated with Congenital Diaphragmatic Hernia by WT1 Gene Mutation
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Park YJ, Oh JW, Choi KM, Kim PK, Lee JI, Song JS
- KMID: 2197134
- J Korean Soc Pediatr Nephrol.
- 2009 Apr;13(1):84-91.
We experienced a female neonate with congenital nephrotic syndrome (CNS) associated with congenital diaphragmatic hernia (CDH). Because of the rare combination of two conditions, we report this case with literature... -
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- Role of DCC(Deleted in Colorectal Cancer) Gene in Oral Squamous Cell Carcinoma
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Ko SK, Han SJ, Kim KW
- KMID: 2005383
- J Korean Assoc Oral Maxillofac Surg.
- 2008 Oct;34(5):518-524.
Chromosome 18q alteration plays a key role in colorectal tumorigenesis, and loss of heterozygosity at 18q is associated with a poor prognosis in colon cancer. DCC(Deleted in Colorectal Cancer) is... -
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- Comparison of PCR-RFLP and Real-Time PCR for Allelotyping of Single Nucleotide Polymorphisms of RRM1, a Lung Cancer Suppressor Gene
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Jeong JY, Kim MR, Son JG, Jung JP, Oh IJ, Kim KS, Kim YC
- KMID: 2318944
- Tuberc Respir Dis.
- 2007 May;62(5):406-416.
BACKGROUND: Single nucleotide polymorphisms (SNPs), which consist of a substitution of a single nucleotide pair, are the most abundant form of genetic variations occurring with a frequency of approximately 1... -
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- Genomic gain and loss of cervical cancer using BAC Chip
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Ding GH, Bae SM, Kwak SY, Min HJ, Lee A, Yu HJ, Namkoong J, Oh EK, Shin JE, Choe JH, Tong SY, Shin SJ, Kim YW, Shin JC, Han BD, Kim CK, Ahn WS
- KMID: 2077664
- Korean J Obstet Gynecol.
- 2006 Sep;49(9):1881-1891.
OBJECTIVE: Cervical cancer has long been linked to the sexually transmitted human papillomavirus (HPV), and the oncoproteins E6 and E7 disrupt the functions of tumour suppressor genes, resulting in genetic... -
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- A Clinical Analysis of Methylation Status of Tumor Suppressor Genes in Breast Cancer
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Jung H, An CH, Kim KH, Kim JI, Park WC, Song BJ, Jung SS, Lim KW, Kim JS
- KMID: 2210309
- J Korean Surg Soc.
- 2006 Apr;70(4):253-264.
PURPOSE: Aberrant methylation of CpG islands in gene promoters has been considered as a common mechanism for suppressing gene expression in cells. Hypermethylation of CpG islands in promoters is associated... -
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- Mutational Research of von Hippel-Lindau Gene of Family with von Hippel-Lindau Disease
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Eom KS, Kim TY, Kim JM
- KMID: 1955776
- J Korean Neurosurg Soc.
- 2003 Sep;34(3):197-201.
OBJECTIVE: The von Hippel-Lindau (VHL) disease is an autosomal dominant disorder caused by deletions or mutations in a tumor suppressor gene on human chromosome 3p25. We investigate the VHL germline... -
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- Gene Expression in Gastric Adenocarcinomas
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Lee JH, Choi SR, Han SY, Hwang TH, Kim MC, Jung GJ, Roh MS, Jeong JS
- KMID: 2184629
- J Korean Gastric Cancer Assoc.
- 2002 Dec;2(4):213-220.
PURPOSE: The cDNA microarray provides a powerful alternative with an unprecedented view in monitoring gene- expression levels and leads to discoveries of regulatory pathways involved in complicated biological processes. Our... -
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- Loss of PTEN Expression in Primary Lung Cancer
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Roh MS
- KMID: 2275559
- Korean J Pathol.
- 2002 Oct;36(5):286-291.
BACKGROUND: The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene, a candidate tumor suppressor, is localized to chromosome 10q23 and shares extensive homology with cytoskeletal proteins auxilin and... -
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- Genetic Polymorphism of Xenobiotics Metabolizing Enzymes and Individual Susceptible Genes to Colorectal Cancer Patients in Korea
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Lee HW, Kim MS, Jung PJ, Kim HJ, Kong G, Chun H
- KMID: 2025764
- J Korean Soc Coloproctol.
- 2002 Aug;18(4):205-215.
Individual susceptibility to cancers may result from several factors including differences in xenobiotics metabolism, DNA repair, altered oncogenes and suppressor genes, and environmental carcinogen exposures. To determine the frequencies of... -
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- Mutations of the p53 tumor suppressor gene in rheumatoid arthritis synovium
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Han CW, Kim HK, Kim WY, Lee KW, Ohm EY, Kim JM
- KMID: 2105712
- J Korean Orthop Assoc.
- 2001 Feb;36(1):9-16.
PURPOSE: To analyse the expression of the p53 tumour suppressor gene in the synovial tissue from rheumatoid patients. Material and Methods : Synovial membranes were obtained from 13 patients diagnosed... -
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- Genetic susceptibilities of cytochrome P450 1A1, 2E1, and N-acetyltransferase 2 to the risks for Korean head and neck cancer patients
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Lee YS, Kim TG, Woo SS, Shim KS, Kong G
- KMID: 2009658
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2000 Jul;22(4):373-382.
Individual genetic susceptibilities to cancers may result from several factors including differences in xenobiotics metabolism to chemical carcinogens, DNA repair, altered oncogenes and suppressor genes, and environmental carcinogen exposures. Among... -
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- Significance of K-ras Mutation and p53 Protein Expression in Pancreatic Adenocarcinoma
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Kim YC, Choi KH
- KMID: 2145297
- J Korean Surg Soc.
- 2000 Feb;58(2):271-279.
BACKGROUND: Activation of the K-ras oncogene by specific point mutations at codon 12 occurs at a remarkably high frequency in pancreatic adenocarcinomas. Also, inactivation of the p53 suppressor gene function... -
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- p53 Suppressor Gene Ove rex p ression in the Cornea after Mechanical-and Chemical-induced Epithelial Injury
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Ko CH, Lee DH, Joo MJ
- KMID: 2205549
- J Korean Ophthalmol Soc.
- 1999 Sep;40(9):2378-2384.
p53 suppressor gene expression and protein production increases in response to DNA damage and the subsequent cell cycle prolongation permits DNA repair or, in the severe cases, leads to apoptosis.... -
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- TGF-beta1 inhibition of apoptosis through the transcriptional up-regulation of Bcl-X(L) in human monocytic leukemia U937 cells
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Lee JH, Park BJ, Park JH, Yang MH, Chi SG
- KMID: 755040
- Exp Mol Med.
- 1999 Sep;31(3):126-133.
To characterize the TGF-beta1 response of monocytic leukemia cells, we analyzed the effects of TGF-beta1 on cell proliferation, differentiation, and apoptosis of human monoblastic U937 cells. Treatment of cells with TGF-beta1 in... -
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- Administration of multiple cytokine genes with anti-tumor activity inhibits both tumor incidence and tumor growth
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Jang HS, Cho TH, Jang YS, Choung PH
- KMID: 711662
- Yonsei Med J.
- 1999 Aug;40(4):355-362.
- doi: 10.3349/ymj.1999.40.4.355
The finding of reporter gene expression in muscle cells after intramuscular injection of a reporter gene containing DNA has suggested that injection of a certain gene in its... -
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- Prognostic Implication of p53 Immunohistochemical Staining in Patients with Localized Renal Cell Carcinoma after Radical Nephrectomy
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Lee SJ, Kim DK, Lee CH, Chang SG, Kim JI, Kim YW
- KMID: 2289960
- Korean J Urol.
- 1999 Mar;40(3):297-302.
PURPOSE: p53 gene is a well-known suppressor gene of tumor. And the p53 protein expression in immunohistochemical staining acts a role as a prognostic indicator in prostate and bladder tumor.... -
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- The Expression of p53, c-erbB-2 and nm23 Proteins in Breast Cancer
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Lee KY, Kim YG, Kim YS, Han KJ, Kang CS, Kim JA, Kim WI, Shim SI
- KMID: 1921777
- Korean J Pathol.
- 1999 Feb;33(2):88-95.
Recently, p53, c-erbB-2 and nm23 proteins have been studied in breast cancer. The expression of p53 protein indicates the mutation of p53 gene known as a tumor supressor gene, and... -
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- nm23 Protein Immunohistochemical Expression in Colorectal Carcinoma and its Relationship with Other Prognostic Factors
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Lee SN, Koo H, Han WS
- KMID: 2141051
- Korean J Pathol.
- 1998 Jun;32(6):413-419.
The purpose of this study was to determine the immunohistochemical expression of nm23-H1, a putative metastatic suppressor gene, and to correlate its expression with clinicopathologic variables in 75 cases of... -
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- Loss of heterozygosity on chromosome XP22.2-p22.13 and Xq26.1-q27.1 in human breast carcinomas
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Choi C, Kim MH, Juhng SW
- KMID: 1745556
- J Korean Med Sci.
- 1998 Jun;13(3):311-316.
- doi: 10.3346/jkms.1998.13.3.311
In an attempt to investigate the X chromosome harboring putative tumor suppressor genes (TSGs) in sporadic breast carcinoma, we performed loss of heterozygosity (LOH) studies on 23 breast carcinomas... -
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