- Dietary nobiletin suppresses TGF-β1-Src-caveolin-1 dependent signaling involved with high glucose-induced renal mesangial matrix accumulation
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Kim DY, Kang YH, Kang MK
- KMID: 2471118
- J Nutr Health.
- 2020 Feb;53(1):1-12.
- doi: 10.4163/jnh.2020.53.1.1
PURPOSE: Diabetic nephropathy is one of the most important diabetic complications prompted by chronic hyperglycemia, characterized by glomerulosclerosis, tubular fibrosis, and it eventually causes kidney failure. Nobiletin is a polymethoxyflavone... -
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- Rab25 Deficiency Perturbs Epidermal Differentiation and Skin Barrier Function in Mice
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Jeong H, Lim KM, Goldenring JR, Nam KT
- KMID: 2462882
- Biomol Ther.
- 2019 Nov;27(6):553-561.
- doi: 10.4062/biomolther.2019.125
Rab25, a member of the Rab11 small GTPase family, is central to achieving cellular polarity in epithelial tissues. Rab25 is highly expressed in epithelial cells of various tissues including breast,... -
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- Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types
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Kim JJ, Kim KS, Eom J, Lee JB, Seo JY
- KMID: 2461197
- Immune Netw.
- 2019 Oct;19(5):e33.
- doi: 10.4110/in.2019.19.e33
Viperin is an IFN-stimulated gene (ISG)-encoded protein that was identified in human primary macrophages treated with IFN-γ and in human primary fibroblasts infected with cytomegalovirus (CMV). This protein plays multiple... -
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- The role of the exocyst in renal ciliogenesis, cystogenesis, tubulogenesis, and development
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Lipschutz
- KMID: 2457718
- Kidney Res Clin Pract.
- 2019 Sep;38(3):260-266.
- doi: 10.23876/j.krcp.19.050
The exocyst is a highly conserved eight-subunit protein complex (EXOC1–8) involved in the targeting and docking of exocytic vesicles translocating from the trans-Golgi network to various sites in renal cells.... -
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- Diverse Effects of Small Molecule Inhibitors on Actin Cytoskeleton Dynamics in HIV-1 Infection
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Shin Y, Choi BS, Kim KC, Kim K, Yoon CH
- KMID: 2452048
- J Bacteriol Virol.
- 2019 Jun;49(2):69-80.
- doi: 10.4167/jbv.2019.49.2.69
The dynamics of the actin cytoskeleton plays a pivotal role in the process of cell division, the transportation of organelles, vesicle trafficking and cell movement. Human immunodeficiency virus type 1... -
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- Farnesylation-defective Rheb Increases Axonal Length Independently of mTORC1 Activity in Embryonic Primary Neurons
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Choi S, Sadra A, Kang J, Ryu JR, Kim JH, Sun W, Huh SO
- KMID: 2450212
- Exp Neurobiol.
- 2019 Apr;28(2):172-182.
- doi: 10.5607/en.2019.28.2.172
Rheb (Ras homolog enriched in the brain) is a small GTPase protein that plays an important role in cell signaling for development of the neocortex through modulation of mTORC1 (mammalian-target-of-rapamycin-complex-1)... -
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- Rab GTPases as Physiological Substrates of LRRK2 Kinase
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Seol W, Nam D, Son I
- KMID: 2450209
- Exp Neurobiol.
- 2019 Apr;28(2):134-145.
- doi: 10.5607/en.2019.28.2.134
LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 harbors GTPase and kinase activities, two enzyme activities... -
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- Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation
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Hong SW, Lee J, Kwon H, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY
- KMID: 2447031
- Endocrinol Metab.
- 2018 Sep;33(3):403-412.
- doi: 10.3803/EnM.2018.33.3.403
BACKGROUND: Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current... -
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- Mon1 Is Essential for Fungal Virulence and Stress Survival in Cryptococcus neoformans
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Son YE, Jung WH, Oh SH, Kwak JH, Cardenas M, Park HS
- KMID: 2428809
- Mycobiology.
- 2018 Jun;46(2):114-121.
- doi: 10.1080/12298093.2018.1468053
Mon1 is a guanine nucleotide exchange factor subunit that activates the Ypt7 Rab GTPase and is essential for vacuole trafficking and autophagy in eukaryotic organisms. Here, we identified and characterized... -
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- Association of MicroRNA Biogenesis Genes Polymorphisms with Ischemic Stroke Susceptibility and Post-Stroke Mortality
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Kim JO, Bae J, Kim J, Oh SH, An HJ, Han IB, Oh D, Kim OJ, Kim NK
- KMID: 2424442
- J Stroke.
- 2018 Jan;20(1):110-121.
- doi: 10.5853/jos.2017.02586
BACKGROUND AND PURPOSE: MicroRNA (miRNA) expression has been examined in multiple conditions, including various cancers, neurological diseases, and cerebrovascular diseases, particularly stroke. Existing evidence indicates that miRNA biosynthesis and function... -
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- Survive or thrive: tradeoff strategy for cellular senescence
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Park SC
- KMID: 2386962
- Exp Mol Med.
- 2017 Jun;49(6):e342.
- doi: 10.1038/emm.2017.94
Aging-dependent cellular behaviors toward extrinsic stress are characterized by the confined localization of certain molecules to either nuclear or perinuclear regions. Although most growth factors can activate downstream signaling in... -
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- Radiologic and Pathologic Findings of a Follicular Variant of Papillary Thyroid Cancer with Extensive Stromal Fat: A Case Report
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Choi JW, Kim TH, Roh HG, Moon WJ, Lee SH, Hwang TS, Park KS
- KMID: 2344291
- Korean J Radiol.
- 2015 Dec;16(6):1349-1352.
- doi: 10.3348/kjr.2015.16.6.1349
Thyroid cancer may have small adipose structures detected by microscopy. However, there are no reports of thyroid cancer with gross fat evaluated by radiological methods. We reported a case of... -
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- Viriditoxin Induces G2/M Cell Cycle Arrest and Apoptosis in A549 Human Lung Cancer Cells
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Park JH, Noh TH, Wang H, Kim ND, Jung JH
- KMID: 2312911
- Nat Prod Sci.
- 2015 Dec;21(4):282-288.
- doi: 10.20307/nps.2015.21.4.282
Viriditoxin is a fungal metabolite isolated from Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai. Viriditoxin was reported to inhibit polymerization of FtsZ, which is a key... -
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- Vav3, a GEF for RhoA, Plays a Critical Role under High Glucose Conditions
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Sha J, Na J, Lee JO, Kim N, Lee SK, Kim JH, Moon JW, Kim SJ, Lee HJ, Choi JI, Park SH, Kim HS
- KMID: 2169474
- Endocrinol Metab.
- 2014 Sep;29(3):363-370.
- doi: 10.3803/EnM.2014.29.3.363
BACKGROUND: The role of small GTPase molecules is poorly understood under high glucose conditions. METHODS: We analyzed the expression pattern of Vav3 in skeletal muscle C2C12 cells under high glucose culture... -
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- Clathrin and Lipid Raft-dependent Internalization of Porphyromonas gingivalis in Endothelial Cells
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Kim SY, Kim SH, Choi EK, Paek YW, Kang IC
- KMID: 1727430
- Int J Oral Biol.
- 2014 Sep;39(3):131-136.
Porphyromonas gingivalis is one of the most important periodontal pathogens and has been to known to invade various types of cells, including endothelial cells. The present study investigated the mechanisms... -
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- Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells
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Zhang H, An F, Tang L, Qiu R
- KMID: 2285499
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):109-120.
- doi: 10.4196/kjpp.2014.18.2.109
The epothilones are a class of microtubule inhibitors that exhibit a strong antitumor activity. UTD2 is a novel epothilone analog generated by genetic manipulation of the polyketide biosynthetic gene cluster.... -
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- A Novel 5'-Uncoding Region -1248 A>G Variation of Mitofusin-2 Gene Is Associated with Hypertension in Chinese
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Wang Z, Liu Y, Liu J, Niu Q, Wen J, Wen S, Wu Z
- KMID: 1727871
- Yonsei Med J.
- 2013 May;54(3):603-608.
- doi: 10.3349/ymj.2013.54.3.603
PURPOSE: Mitofusin2 gene (Mfn2, also named Hyperplasia suppressive gene, HSG) is very important in the origin and development of hypertension. However, the mechanism of Mfn2/HSG expression regulation was not uncovered.... -
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- Rho-Associated Kinase 2 Polymorphism in Patients With Vasospastic Angina
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Yoo SY, Kim J, Cheong S, Shin DH, Jang J, Lee C, Tahk SJ, Shin JH, Choi SY, Yoon MH
- KMID: 1433860
- Korean Circ J.
- 2012 Jun;42(6):406-413.
- doi: 10.4070/kcj.2012.42.6.406
BACKGROUND AND OBJECTIVES: Recent studies indicate that in response to vasoconstrictor stimuli, the small GTPase RhoA and its down-stream effector, Rho-associated kinase 2 (ROCK)/Rho-kinase, are associated with hypercontraction of the... -
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- Role of Regulators of G-Protein Signaling 4 in Ca2+ Signaling in Mouse Pancreatic Acinar Cells
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Park S, Lee SI, Shin DM
- KMID: 2285425
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):383-388.
- doi: 10.4196/kjpp.2011.15.6.383
Regulators of G-protein signaling (RGS) proteins are regulators of Ca2+ signaling that accelerate the GTPase activity of the G-protein alpha-subunit. RGS1, RGS2, RGS4, and RGS16 are expressed in the pancreas,... -
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- Overexpression of MMP-9 and HIF-1alpha in Breast Cancer Cells under Hypoxic Conditions
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Choi JY, Jang YS, Min SY, Song JY
- KMID: 2286506
- J Breast Cancer.
- 2011 Jun;14(2):88-95.
- doi: 10.4048/jbc.2011.14.2.88
PURPOSE: Hypoxia, which is a loss of oxygen in tissues, is a common condition in solid tumors due to the tumor outgrowing existing vasculature. Under hypoxic conditions, hypoxia-inducible factor (HIF)-1alpha... -
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