- Nickel (II)-induced apoptosis and G2/M enrichment
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Lee SH, Kim DK, Seo YR, Woo KM, Kim CS, Cho MH
- KMID: 1109301
- Exp Mol Med.
- 1998 Sep;30(3):171-176.
Treatment with certain DNA-damaging agents induce a complex cellular response comprising pertubation of cell cycle progression and/or apoptosis on proliferating mammalian cells. Our studies were focused on the cellular effects of nickel (II)... -
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- p53 Prevents Immature Escaping from Cell Cycle G2 Checkpoint Arrest through Inhibiting cdk2-dependent NF-Y Phosphorylation
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Yun UJ, Park HD, Shin DY
- KMID: 2166051
- Cancer Res Treat.
- 2006 Dec;38(4):224-228.
PURPOSE: Recent studies have suggested that p53 regulates the G2 checkpoint in the cell cycle and this function is required for the maintenance of genomic integrity. In this study, we... -
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- Cell Death Induction Mechanism of Non-small Cell Lung Cancer Cell Line, NCI-H1703 by Docetaxel
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Ha HC, Kim YD, Song SH, Park CS, Kim JW
- KMID: 1878599
- Korean J Thorac Cardiovasc Surg.
- 2006 Sep;39(9):668-673.
BACKGROUND: Docetaxel has been effectively used as an anti-cancer chemotherapuetic agent for various tumor treatments including lung cancer. However, the cell death induction mechanism(s) involved with docetaxel treatment in lung... -
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- Cell cycling status of human cord blood CD34+ cells during ex vivo expansion is related to the level of very late antigen expression
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Seoh JY, Park HY, Chung WS, Kim SC, Hahn MJ, Kim KH, Shin HY, Ahn HS, Park KW, Ryu KH
- KMID: 1066489
- J Korean Med Sci.
- 2001 Feb;16(1):20-24.
- doi: 10.3346/jkms.2001.16.1.20
Very late antigen-4 (VLA-4), which binds to the extracellular matrix protein fibronectin, is an integrin molecule known to be modulated during mobilization of CD34+ cells, and to be involved in... -
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- Helicobacter pylori inhibited cell proliferation in human periodontal ligament fibroblasts through the Cdc25C/CDK1/cyclinB1 signaling cascade
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Li H, Liang D, Hu N, Dai X, He J, Zhuang H, Zhao W
- KMID: 2454084
- J Periodontal Implant Sci.
- 2019 Jun;49(3):138-147.
- doi: 10.5051/jpis.2019.49.3.138
PURPOSE: Several studies have shown that the oral cavity is a secondary location for Helicobacter pylori colonization and that H. pylori is associated with the severity of periodontitis. This study... -
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- The Changes of Cell Cycle Phase Fractions and Expression of p53 by the Treatment of Staurosporine in MCF-7 Cell Line
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Nam J, Yea KA, Lee HN, Jo HH, Ryu KS, Lew YO, Rha JG, Han KT
- KMID: 2076195
- Korean J Obstet Gynecol.
- 2001 Mar;44(3):501-505.
OBJECTIVE: We investigated the effects on the cell cycle and p53 expression by the treatment of various concentrations of staurosporine to elucidate the molecular mechanism of staurosporine induced cell cycle... -
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- Effects of HMGB-1 Overexpression on Cell-Cycle Progression in MCF-7 Cells
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Yoon S, Lee JY, Yoon BK, Bae DS, Choi DS
- KMID: 1786806
- J Korean Med Sci.
- 2004 Jun;19(3):321-326.
- doi: 10.3346/jkms.2004.19.3.321
High mobility group-1 (HMGB-1) enhances the DNA interactions and possesses a transcriptional activation potential for several families of sequence-specific transcriptional activators. In order to examine the effect of HMGB-1 on... -
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- Regulatory Mechanism of Radiation-induced Cancer Cell Death by the Change of Cell Cycle
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Jeong SJ, Jeong MH, Jang JY, Jo WS, Nam BH, Jeong MZ, Lim YJ, Jang BG, Youn SM, Lee HS, Hur WJ, Yang KM
- KMID: 2097228
- J Korean Soc Ther Radiol Oncol.
- 2003 Dec;21(4):306-314.
PURPOSE: In our previous study, we have shown the main cell death pattern induced by irradiation or protein tyrosine kinase (PTK) inhibitors in K562 human myelogenous leukemic cell line. Death... -
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- Alteration of Cell Cycle in Cervical Tumor Associated with Human Papillomavirus: Cyclin-Dependent Kinase Inhibitors
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Cho NH, Kim YT, Kim JW
- KMID: 1093947
- Yonsei Med J.
- 2002 Dec;43(6):722-728.
- doi: 10.3349/ymj.2002.43.6.722
The ability of viral oncoproteins to subvert cell cycle checkpoints may constitute a mechanism by which viral oncoproteins induce genetic instability. HPV 16 E6 and E7 disrupt cell cycle checkpoints,... -
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- ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells
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Wang L, Wang QT, Liu YP, Dong QQ, Hu HJ, Miao Z, Li S, Liu Y, Zhou H, Zhang TC, Ma WJ, Luo XG
- KMID: 2398796
- J Gastric Cancer.
- 2017 Dec;17(4):295-305.
- doi: 10.5230/jgc.2017.17.e33
PURPOSE: We previously found that the histone methyltransferase suppressor of variegation, enhancer of zeste, trithorax and myeloid-nervy-deformed epidermal autoregulatory factor-1 domain-containing protein 3 (SMYD3) is a potential independent predictive factor... -
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- Altered remodeling of nucleolar machineries in cultured hepatocytes treated with thioacetamide
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Jeong JS, Han SY, Kim YH, Choi YC
- KMID: 1066498
- J Korean Med Sci.
- 2001 Feb;16(1):75-82.
- doi: 10.3346/jkms.2001.16.1.75
Thioacetamide (TA) is converted into a hyperacetylating agent which causes hepatic necrosis, regeneration, cirrhosis and cancerous transformation. One of the most characteristic toxicities of TA in rat is observed with... -
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- The colchicine derivative CT20126 shows a novel microtubule-modulating activity with apoptosis
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Kim SK, Cho SM, Kim H, Seok H, Kim SO, Kwon TK, Chang JS
- KMID: 2154238
- Exp Mol Med.
- 2013 Apr;45(4):e19.
New colchicine analogs have been synthesized with the aim of developing stronger potential anticancer activities. Among the analogs, CT20126 has been previously reported to show immunosuppressive activities. Here, we report... -
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- Expression of TGF-alpha, p53 and PCNA in Laryngeal Dysplasia
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Choi JO, Kim KH, Chung K, Choi K, Yeom BW, Min HK
- KMID: 2274320
- Korean J Otolaryngol-Head Neck Surg.
- 1997 Jun;40(6):861-868.
BACKGROUND: Transforming growth factor(TGF-alpha) is a polypeptide which is structurally related to epidermal growth factor(EGF) and binds to the epidermal growth factor receptor(EGFR). TGF-alpha utilizes EGFR to increase the activation... -
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- Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells
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Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
- KMID: 2069926
- J Korean Med Sci.
- 2014 Nov;29(11):1464-1472.
- doi: 10.3346/jkms.2014.29.11.1464
Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition... -
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- Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells
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Hong YB, Kang HJ, Kim HJ, Rosen EM, Dakshanamurthy S, Rondanin R, Baruchello R, Grisolia G, Daniele S, Bae I
- KMID: 1123462
- Exp Mol Med.
- 2009 Mar;41(3):151-160.
- doi: 10.3858/emm.2009.41.3.018
Resveratrol has been reported to possess cancer preventive properties. In this study, we analyzed anti-tumor activity of a newly synthesized resveratrol analog, cis-3,4',5-trimethoxy-3'-hydroxystilbene (hereafter called 11b) towards breast and pancreatic... -
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- Effects of Chromosomal Polyploidy on Survival of Colon Cancer Cells
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Park SU, Choi ES, Jang YS, Hong SH, Kim IH, Chang DK
- KMID: 1128353
- Korean J Gastroenterol.
- 2011 Mar;57(3):150-157.
- doi: 10.4166/kjg.2011.57.3.150
BACKGROUND/AIMS: Tetraploid cells are frequently observed in the inflamed mucosal epithelial cells of the patients with Barrett's esophagus or chronic ulcerative colitis. Polyploidy often occurs during cell fusion, abortive cell... -
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- Inhibitory Effect of Melanoma Differentiation Associated Gene-7/Interleukin-24 on Invasion In Vitro of Human Melanoma Cancer Cells
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Lin BW, Jiao ZL, Fan JF, Peng L, Li L, Zhao ZG, Ding XY, Li HJ
- KMID: 2158029
- J Korean Med Sci.
- 2013 Jun;28(6):833-839.
- doi: 10.3346/jkms.2013.28.6.833
The acquisition of metastasis potential is a critical point for malignant tumors. Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a potential tumor suppress gene and frequently down-regulated in malignant tumors. It... -
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