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Recombinant Human Thioredoxin-1 Protects Macrophages from Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation and Cell Apoptosis

Zhang H, Liu Q, Lin JL, Wang Y, Zhang RX, Hou JB, Yu B

Oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and apoptosis play critical roles in the pathogenesis of atherosclerosis. Thioredoxin-1 (Trx) is an antioxidant that potently protects various cells from oxidative...
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Outcomes of Surgical Management of Xanthelasma Palpebrarum

Lee HY, Jin US, Minn KW, Park YO

BACKGROUND: Xanthelasma palpebrarum (XP) is a benign disorder manifesting as yellowish cholesterol-laden plaques on the eyelids. This paper presents the outcomes in patients with XP who have undergone surgical excision...
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Verruciform xanthoma of the palatal gingiva: a report of two cases

Ryu DJ, Lee SH, Yuk JI, Kim HJ, Huh JK, Park KH

Verruciform xanthoma (VX) is a rare, benign lesion that presents in the oral cavity, skin, or genital organs as a verrucous, papillomatous, or flat papule with varying colors. VX has...
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Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1

Park DW, Baek K, Kim JR, Lee JJ, Ryu SH, Chin BR, Baek SH

Resveratrol is a polyphenolic compound in red wine that has anti-oxidant and cardioprotective effects in animal models. Reactive oxygen species (ROS) and monocyte chemotactic protein-1 (MCP-1) play key roles in...
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Chemokine Lkn-1/CCL15 enhances matrix metalloproteinase-9 release from human macrophages and macrophage-derived foam cells

Kwon SH, Ju SA, Kang JH, Kim CS, Yoo HM, Yu R

  • KMID: 2313362
  • Nutr Res Pract.
  • 2008 Jun;2(2):134-137.
Atherosclerosis is characterized by a chronic inflammatory disease, and chemokines play an important role in both initiation and progression of atherosclerosis development. Leukotactin-1 (Lkn-1/CCL15), a new member of the human...
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A case of Niemann-Pick disease type A

Yu HY, Oh JE, Park JS, Kim MH, Kim SD, Jung KS

Niemann-Pick disease is a group of autosomal recessive disorders associated with hepatosplenomegaly, variable neurologic deficits, and the storage of sphingomyelin and other lipids. Seven cases have been reported in Korea....
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Antioxidative Effects of Water-Soluble Chitinous Compounds on Oxidation of Low Density Lipoprotein in Macrophages

Lee SH, Park SH, Lee YJ, Yoon Park , Choi YJ, Choi JS, Kang YH

  • KMID: 2269697
  • Korean J Nutr.
  • 2003 Nov;36(9):908-917.
It has been proposed that oxidative modification of LDL (oxLDL) plays a significant role in the pathogenicity of atherogenesis. We tested the hypothesis that chitin and chitosan may function as...
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Chronological effects of atherogenic diets on the aorta, liver and spleen of rabbits

Song SH, Min BI, Lee JH, Cho KS

To investigate the temporal progression of atherogenesis on the aorta and involvement of the monocyte-macrophage system in the liver and spleen, we fed 74 rabbits with high fat (14 or...
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Prevalence of foam cells and helper-T cells in atherosclerotic plaques of Korean patients with carotid atheroma

Lee WH, Ko YH, Kim DI, Lee BB, Park JE

  • KMID: 759503
  • Korean J Intern Med.
  • 2000 Jul;15(2):117-121.
BACKGROUND: Inflammation and activation of immune cells have important roles in the pathogenesis of atherosclerosis. We analyzed the involvement of various immune...
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A Case of Type A Niemann-Pick Disease

Jeon EY, Choi KA, Koo CH, Lee WM, Jeon YS, Lee CH, Suh KS, Lee SK

  • KMID: 2335319
  • J Korean Pediatr Soc.
  • 1998 Feb;41(2):275-280.
Niemann-Pick disease is a storage disease characterized by accumulation of sphingomyelin and other lipids, mainly in the reticuloendothelial system. We experienced a case of type A Niemann-Pick disease in a...
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