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Symmetrical Giant Facial Plaque-Type Juvenile Xanthogranuloma: A Case Report with a Successful Response to Fractional COâ‚‚ Laser Treatment

Lee YI, Oh SH

Symmetrical giant facial plaque-type juvenile xanthogranuloma (SGFP-JXG) is a rare variant of juvenile xanthogranuloma, reported only in two cases in the literature. We report a case of a 3-year-old Korean...
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Recombinant Human Thioredoxin-1 Protects Macrophages from Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation and Cell Apoptosis

Zhang H, Liu Q, Lin JL, Wang Y, Zhang RX, Hou JB, Yu B

Oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and apoptosis play critical roles in the pathogenesis of atherosclerosis. Thioredoxin-1 (Trx) is an antioxidant that potently protects various cells from oxidative...
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LPS-stimulated Macrophage Activation Affects Endothelial Dysfunction

Baek N, Sim S, Heo KS

Intestinal microbiota is involved in the atherosclerotic process by development of an atheromatous core with foam cells in carotid arteries. It has reported that lipopolysaccharide (LPS) from Escherichia coli localizes...
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Porphyromonas gingivalis accelerates atherosclerosis through oxidation of high-density lipoprotein

Kim HJ, Cha GS, Kim HJ, Kwon EY, Lee JY, Choi J, Joo JY

PURPOSE: The aim of this study was to evaluate the ability of Porphyromonas gingivalis (P. gingivalis) to induce oxidation of high-density lipoprotein (HDL) and to determine whether the oxidized HDL...
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The Role of Macrophage Lipophagy in Reverse Cholesterol Transport

Jeong SJ, Lee MN, Oh GT

Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step...
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Linking resistin, inflammation, and cardiometabolic diseases

Park HK, Kwak MK, Kim HJ, Ahima RS

Adipose tissue secretes a variety of bioactive substances that are associated with chronic inflammation, insulin resistance, and an increased risk of type 2 diabetes mellitus. While resistin was first known...
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IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation

Zhang HF, Wu MX, Lin YQ, Xie SL, Huang TC, Liu PM, Nie RQ, Meng QQ, Luo NS, Chen YX, Wang JF

We evaluated the role of IL-10- in IL-33-mediated cholesterol reduction in macrophage-derived foam cells (MFCs) and the mechanism by which IL-33 upregulates IL-10. Serum IL-33 and IL-10 levels in coronary...
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Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk

Jin L, Lin Z, Xu A

Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on energy metabolism and insulin sensitivity. Besides its antiobese and antidiabetic activity, FGF21 also possesses the protective effects...
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Verruciform xanthoma in the hard palate: a case report and literature review

Garcia AS, Pagin O, da Silva Santos PS, Oliveira D

Oral verruciform xanthoma (OVX) is an uncommon lesion that appears on the oral mucosa. The aim of this paper was to discuss the probable etiopathogenesis of OVX in the hard...
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Contribution of Periodontal Disease in Atherosclerosis

Na HS, Chung J

Periodontitis is a disease that leads to destruction of the soft and hard tissues of periodontium, which can result in periodontal bone loss and tooth loss in severe cases. Atherosclerosis...
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Acute Atherosis of the Uterine Spiral Arteries: Clinicopathologic Implications

Kim JY, Kim YM

Acute atherosis is unique vascular changes of the placenta associated with poor placentation. It is characterized by subendothelial lipid-filled foam cells, fibrinoid necrosis of the arterial wall, perivascular lymphocytic infiltration,...
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Pycnogenol attenuates atherosclerosis by regulating lipid metabolism through the TLR4-NF-kappaB pathway

Luo H, Wang J, Qiao C, Ma N, Liu D, Zhang W

Atherosclerosis is a leading cause of death worldwide and is characterized by lipid-laden foam cell formation. Recently, pycnogenol (PYC) has drawn much attention because of its prominent effect on cardiovascular...
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Intertriginous Xanthoma in an Infant with Familial Hypercholesterolemia

Kim YU, Lee SW, Kim KJ, Heo EP

  • KMID: 2246371
  • Korean J Dermatol.
  • 2014 Mar;52(3):178-181.
Familial hypercholesterolemia is an autosomal dominant inherited metabolic disease characterized by high serum low-density lipoprotein (LDL) cholesterol concentrations, and xanthoma formation. There are multiple types of xanthomas, such as eruptive,...
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Outcomes of Surgical Management of Xanthelasma Palpebrarum

Lee HY, Jin US, Minn KW, Park YO

BACKGROUND: Xanthelasma palpebrarum (XP) is a benign disorder manifesting as yellowish cholesterol-laden plaques on the eyelids. This paper presents the outcomes in patients with XP who have undergone surgical excision...
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Targeting Cellular Antioxidant Enzymes for Treating Atherosclerotic Vascular Disease

Kang DH, Kang SW

  • KMID: 1502509
  • Biomol Ther.
  • 2013 Mar;21(2):89-96.
Atherosclerotic vascular dysfunction is a chronic inflammatory process that spreads from the fatty streak and foam cells through lesion progression. Therefore, its early diagnosis and prevention is unfeasible. Reactive oxygen...
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Resistin in Rodents and Humans

Park HK, Ahima RS

Obesity is characterized by excess accumulation of lipids in adipose tissue and other organs, and chronic inflammation associated with insulin resistance and an increased risk of type 2 diabetes. Obesity,...
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Verruciform xanthoma of the palatal gingiva: a report of two cases

Ryu DJ, Lee SH, Yuk JI, Kim HJ, Huh JK, Park KH

Verruciform xanthoma (VX) is a rare, benign lesion that presents in the oral cavity, skin, or genital organs as a verrucous, papillomatous, or flat papule with varying colors. VX has...
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Secondary Anetoderma Developed in Juvenile Xanthogranuloma

Park JM, Mun JH, Song M, Ko HC, Kim BS, Kim MB, Kim HS

  • KMID: 1864413
  • Korean J Dermatol.
  • 2013 Oct;51(10):829-832.
Anetoderma is characterized by a loss of normal elastic tissue, and is clinically presented as atrophic patches located mainly on the upper trunk. It may be primary or secondary, occurring...
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Pathology and Classification of Focal Segmental Glomerulosclerosis

Kim YJ

  • KMID: 2144668
  • J Korean Soc Pediatr Nephrol.
  • 2012 Apr;16(1):21-31.
Focal segmental glomerulosclerosis (FSGS) is the name of the primary glomerular disease as well as the terminology to describe the secondary phenomena of any other glomerular diseases. It is characterized...
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Local tissue reaction after injection of contrast media on gastric wall of mouse: experimental study for application of contrast media to computed tomography lymphography

Hwang SH, Kim HH, Park DJ, Jee YS, Lee KH, Kim YH, Lee HS, Lee HJ, Yang HK

PURPOSE: Computed tomography (CT) lymphography is a simple technique of sentinel node navigation but tissue reaction after injection of contrast media has not been reported yet. METHODS: Ninety mice used in...
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