- Hsp70 Knockdown by siRNA Decreased Collagen Production in Keloid Fibroblasts
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Shin JU, Lee WJ, Tran TN, Jung I, Lee JH
- KMID: 2345891
- Yonsei Med J.
- 2015 Nov;56(6):1619-1626.
- doi: 10.3349/ymj.2015.56.6.1619
PURPOSE: There are currently no consistently effective treatments for the excessive collagen produced by keloid fibroblasts. Previously, we reported that heat shock protein 70 (Hsp70) is up-regulated in keloid fibroblasts... -
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- miR-526b targets 3' UTR of MMP1 mRNA
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Kim KH, Jung JY, Son ED, Shin DW, Noh M, Lee TR
- KMID: 2155432
- Exp Mol Med.
- 2015 Aug;47(8):e178.
- doi: 10.1038/emm.2015.52
Regulation of matrix metalloproteinases (MMPs) is important for many physiological processes involving cancers, inflammation, tissue remodeling and skin aging. Here, we report the novel finding that the expression of MMP1... -
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- Expression of Semaphorin 3A and Neuropilin 1 in Asthma
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Shim EJ, Chun E, Kang HR, Cho SH, Min KU, Park HW
- KMID: 1777678
- J Korean Med Sci.
- 2013 Oct;28(10):1435-1442.
- doi: 10.3346/jkms.2013.28.10.1435
Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis... -
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- Over-expression of extracellular superoxide dismutase in mouse synovial tissue attenuates the inflammatory arthritis
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Yu DH, Yi JK, Yuh HS, Park SJ, Kim HJ, Bae KB, Ji YR, Kim NR, Park SJ, Kim DH, Kim SH, Kim MO, Lee JW, Ryoo ZY
- KMID: 1389732
- Exp Mol Med.
- 2012 Sep;44(9):529-535.
Oxidative stress such as reactive oxygen species (ROS) within the inflamed joint have been indicated as being involved as inflammatory mediators in the induction of arthritis. Correlations between extracellular-superoxide dismutase... -
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- Evaluation of modified vaccinia virus Ankara expressing VP2 protein of infectious bursal disease virus as an immunogen in chickens
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Zanetti FA, Zajac MP, Taboga OA, Calamante
- KMID: 1376195
- J Vet Sci.
- 2012 Jun;13(2):199-201.
- doi: 10.4142/jvs.2012.13.2.199
A recombinant modified vaccinia Ankara (MVA) virus expressing mature viral protein 2 (VP2) of the infectious bursal disease virus (IBDV) was constructed to develop MVA-based vaccines for poultry. We demonstrated... -
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- Transcriptional Regulation of Proteoglycans and Glycosaminoglycan Chain-synthesizing Glycosyltransferases by UV Irradiation in Cultured Human Dermal Fibroblasts
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Shin JE, Oh JH, Kim YK, Jung JY, Chung JH
- KMID: 2157881
- J Korean Med Sci.
- 2011 Mar;26(3):417-424.
- doi: 10.3346/jkms.2011.26.3.417
Various kinds of glycosaminoglycans (GAGs) and proteoglycans (PGs) have been known to be involved in structural and space-filling functions, as well as many physiological regulations in skin. To investigate ultraviolet... -
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- Engagement of Toll-Like Receptor 3 Induces Vascular Endothelial Growth Factor and Interleukin-8 in Human Rheumatoid Synovial Fibroblasts
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Moon SJ, Park MK, Oh HJ, Lee SY, Kwok SK, Cho ML, Ju JH, Park KS, Kim HY, Park SH
- KMID: 964725
- Korean J Intern Med.
- 2010 Dec;25(4):429-435.
- doi: 10.3904/kjim.2010.25.4.429
BACKGROUND/AIMS: Angiogenesis, which is a critical step in the initiation and progression of rheumatoid arthritis (RA), involves pro-angiogenic factors, including interleukin (IL)-8 and vascular endothelial growth factor (VEGF). We investigated... -
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- Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin
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Lee JE, Jang H, Cho EJ, Youn HD
- KMID: 1058021
- Exp Mol Med.
- 2009 Jul;41(7):471-477.
- doi: 10.3858/emm.2009.41.7.052
Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage.... -
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- Autologous somatic cell nuclear transfer in pigs using recipient oocytes and donor cells from the same animal
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Lee E, Song K
- KMID: 1106223
- J Vet Sci.
- 2007 Dec;8(4):415-421.
- doi: 10.4142/jvs.2007.8.4.415
The objective of the present study was to examine the feasibility of the production of autologous porcine somatic cell nuclear transfer (SCNT) blastocysts using oocytes and donor cells from slaughtered... -
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- Effects of Infrared Radiation on Skin Photo-Aging and Pigmentation
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Lee JH, Roh MR, Lee KH
- KMID: 1779497
- Yonsei Med J.
- 2006 Aug;47(4):485-490.
- doi: 10.3349/ymj.2006.47.4.485
Infrared radiation is increasingly and uncritically used for cosmetic and wellness purposes, despite the poorly understood biologic effects of such treatments on humans. In the present study, we investigated the... -
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- Fixation Methods for Implantable Port Chamber: Comparative Study Using Glue, Self-stabilizing Leg and Suture Fixations in Rabbits
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Na HI, Shim HJ, Kwak BK, Kim HJ, Lee YC
- KMID: 1118834
- Korean J Radiol.
- 2004 Dec;5(4):266-273.
- doi: 10.3348/kjr.2004.5.4.266
OBJECTIVE: To evaluate the fixation strength and tissue reaction of the glue fixation and self-stabilizing leg fixation methods and to compare the results with those of the conventional tagging suture... -
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- Age-related decline in expression of calnexin
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Choi BH, Kim JS
- KMID: 1123772
- Exp Mol Med.
- 2004 Oct;36(5):499-503.
Aging is accompanied by the changes in the cells that decrease their capacity to respond to various forms of stress. Cells are known to respond to stresses through expression of... -
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- Biochemical Characteristics of a Korean Patient with Mucolipidosis III (Pseudo-Hurler Polydystrophy)
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Song J, Lee DS, Cho HI, Kim JQ, Cho TJ
- KMID: 1130045
- J Korean Med Sci.
- 2003 Oct;18(5):722-726.
- doi: 10.3346/jkms.2003.18.5.722
We performed a biochemical study on the patient with mucolipidosis III (ML-III, pseudo-Hurler polydystrophy) in Korea. Confluent fibroblasts from the patient and from normal controls were cultured for 4, 12,... -
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- Regulation of type I collagen and interstitial collagenase mRNA expression in human dermal fibroblasts by colchicine and D-penicillamine
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Chung KY, Kang DS
- KMID: 711684
- Yonsei Med J.
- 1999 Oct;40(5):490-495.
- doi: 10.3349/ymj.1999.40.5.490
Sclerosis is a disease process in which idiopathic hardening occurs in the skin and/or internal organs as a result of the accumulation of type I collagen, induced mainly by transforming... -
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- Angiotensin II stimulates proliferation of adventitial fibroblasts cultured from rat aortic explants
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Kim DK, Huh JE, Lee SH, Hong KP, Park JE, Seo JD, Lee WR
- KMID: 646015
- J Korean Med Sci.
- 1999 Oct;14(5):487-496.
- doi: 10.3346/jkms.1999.14.5.487
It has been proposed that the local renin-angiotensin system is activated in the adventitia after vascular injury. However, the physiological role of Angiotensin II (Ang II) in the adventitia has... -
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- Synthesized TGF-beta s in RPE regulates cellular proliferation
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Lee SC, Seong GJ, Kim SH, Kwon OW
- KMID: 1081831
- Korean J Ophthalmol.
- 1999 Jun;13(1):16-24.
- doi: 10.3341/kjo.1999.13.1.16
Retinal pigment epithelial (RPE) cells transdifferentiate in culture, a transition which is accompanied by a shift in biological activity. The present study investigates whether transforming growth factor (TGF)-beta has the... -
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- The regulatory mechanism of phosphatidylinositol 3-kinase by insulin in 3T3 L1 fibroblasts: phosphorylation-independent activation of phosphatidylinositol 3-kinase
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Kang IS, Choi SL, Kim SS, Kim SJ, Ha JH, Oh SM, Kim SS
- KMID: 755019
- Exp Mol Med.
- 1998 Dec;30(4):263-269.
Phosphatidylinositol (PI) 3-kinase plays an important role in transducing the signals of various growth factor receptors. However, the regulatory mechanism of PI3-kinase activity by these growth factor receptors is not... -
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- Interferon-gamma upregulates the stromelysin-1 gene expression by human skin fibroblasts in culture
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Lee KS, Ryoo YW, Song JY
- KMID: 754989
- Exp Mol Med.
- 1998 Jun;30(2):59-64.
The equilibrium between deposition and degradation of extracellular matrix(ECM) is essential to normal tissue development and repair of wound or inflammatory responses. It has recently become apparent that several cytokines and growth factors... -
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