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Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia

Wang C, Fang X

  • KMID: 2514672
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):153-164.
  • doi: 10.5056/jnm20175
Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional gastrointestinal disorders (FGIDs) and account for a large proportion of consulting patients. These 2 disorders overlap with each other...
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A Missense Mutation in TRPS1 in a Family with Trichorhinophalangeal Syndrome Type III Accompanied by Ankylosing Spondylitis

Fang X, Yang Q

Trichorhinophalangeal syndrome (TRPS) is a rare autosomal dominant genetic disorder characterized by distinctive craniofacial features, skeletal abnormalities and short stature; it is classified into three subtypes according to genetics and clinical...
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Acute Flaccid Myelitis: Current Status and Diagnostic Challenges

Fang X, Huda R

Acute flaccid myelitis (AFM) is a sudden-onset polio-like neuromuscular disability found commonly in young children. There is an increasing incidence of confirmed AFM cases in the USA and other countries...
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Neogambogic acid relieves myocardial injury induced by sepsis via p38 MAPK/NF-κB pathway

Fu W, Fang X, Wu L, Hu W, Yang T

Sepsis-associated myocardial injury, an invertible myocardial depression, is a common complication of sepsis. Neogambogic acid is an active compound in garcinia and exerts anthelmintic, anti-inflammatory, and detoxification properties. The role of...
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Non-canonical vs. Canonical Functions of Heme Oxygenase-1 in Cancer

Jagadeesh ASV, Fang X, Kim SH, Guillen-Quispe YN, Zheng J, Surh YJ, Kim SJ

Heme oxygenase-1 (HO-1) is a critical stress-responsive enzyme that has antioxidant and anti-inflammatory functions. HO-1 catalyzes heme degradation, which gives rise to the formation of carbon monoxide (CO), biliverdin, and...
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Electrophysiologic Characteristics of Nitrous-Oxide-Associated Peripheral Neuropathy: A Retrospective Study of 76 Patients

Fang X, Yu M, Zheng D, Gao H, Li W, Ma Y

Background and Purpose The electrophysiologic characteristics of peripheral neuropathy secondary to nitrous oxide (N2O) abuse remain unclear. The paper therefore aimed to summarize the electrophysiologic characteristics of N2O-associated peripheral neuropathy...
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Improved preimplantation development of porcine somatic cell nuclear transfer embryos by caffeine treatment

Kim G, Roy PK, Fang X, Hassan BM, Cho J

This study examined the effects of a caffeine treatment to improve nuclear reprogramming in porcine cloned embryos. Embryonic development and the expression of genes related to pluripotency (POU5F1, SOX2, NANOG,...
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Supplementation of cryoprotective extender with resveratrol decreases apoptosis index and reactive oxygen species levels in post-thaw dog sperm

Bang S, Tanga BM, Qamar AY, Fang X, Seong G, Nabeel AHT, Yu I, Cho J

Resveratrol (RSV, 3,5,4′-trihydroxytrans-stilbene) protects sperm from cryo-induced damage in various animal and human species. In this study, we aimed to assess the effect of dog sperm cryoprotective extender containing RSV...
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Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats

Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H

PURPOSE: Circular RNAs (circRNAs), a novel class of RNAs, perform important functions in biological processes. However, the role of circRNAs in the mammary gland remains unknown. The present study is...
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Genistein Improves the Major Depression through Suppressing the Expression of miR-221/222 by Targeting Connexin 43

Shen F, Huang WL, Xing BP, Fang X, Feng M, Jiang CM

OBJECTIVE: Recent studies have indicated the possibility that genistein may improve depression via regulating the expression of miR-221/222. This study is to explore whether genistein could improve depression by altering...
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Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives

Lin S, Li H, Fang X

  • KMID: 2460478
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):499-507.
  • doi: 10.5056/jnm19081
Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of...
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Fascia Suture Technique Is a Simple Approach to Reduce Postmastectomy Seroma Formation

Cong Y, Cao J, Qiao G, Zhang S, Liu X, Fang X, Zou H, Zhu S

Purpose: Seroma formation is a common complication in breast cancer patients undergoing mastectomy, and it negatively affects patient recovery after surgery. The present study aimed to evaluate a simple method...
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STAT3 as a Potential Target for Tumor Suppressive Effects of 15-Deoxy-Δ12,14-prostaglandin J2 in Triple Negative Breast Cancer

Kim SJ, Cho NC, Hahn YI, Kim SH, Fang X, Surh YJ

STAT3 plays a prominent role in proliferation and survival of tumor cells. Thus, STAT3 has been considered to be a prime target for development of anti-cancer therapeutics. The electrophilic cyclopentenone...
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Depression and Structural Factors Are Associated With Symptoms in Patients of Irritable Bowel Syndrome With Diarrhea

Lu J, Shi L, Huang D, Fan W, Li X, Zhu L, Wei J, Fang X

  • KMID: 2507116
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):505-513.
  • doi: 10.5056/jnm19166
Background/Aims A strong correlation between depression and irritable bowel syndrome with diarrhea (IBS-D) has been identified. The aim of this study is to identify the correlations among depression, structural factors, gastrointestinal...
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Response of Esophagus to High and Low Temperatures in Patients With Achalasia

Ren Y, Ke M, Fang X, Zhu L, Sun X, Wang Z, Wang R, Wei Z, Wen P, Xin H, Chang M

  • KMID: 2325948
  • J Neurogastroenterol Motil.
  • 2012 Oct;18(4):391-398.
BACKGROUND/AIMS: Achalasia patients would feel exacerbated dysphagia, chest pain and regurgitation when they drink cold beverages or eat cold food. But these symptoms would relieve when they drink hot water....
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Abnormalities in Inflammatory Cytokines Confer Susceptible to Chronic Neuropathic Pain-related Anhedonia in a Rat Model of Spared Nerve Injury

Fang X, Zhan G, Zhang J, Xu H, Zhu B, Hu Y, Yang C, Luo A

OBJECTIVE: Patients with chronic neuropathic pain (CNP) have a higher incidence to develop depression. However, its pathogenesis has not yet been fully elucidated. Here we aimed to investigate the role...
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Changes in Enteric Neurons of Small Intestine in a Rat Model of Irritable Bowel Syndrome with Diarrhea

Li S, Fei G, Fang X, Yang X, Sun X, Qian J, Wood JD, Ke M

  • KMID: 2203585
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):310-320.
  • doi: 10.5056/jnm15082
BACKGROUND/AIMS: Physical and/or emotional stresses are important factors in the exacerbation of symptoms in irritable bowel syndrome (IBS). Several lines of evidence support that a major impact of stress on...
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The effect of body mass index and its interaction with family history on hypertension: a case–control study

Li AL, Peng Q, Shao YQ, Fang X, Zhang YY

BACKGROUND: BMI is an indicator commonly used in the world to measure the weight and height of the body, it reflects the comprehensive outcome of acquired lifestyle; FH is a...
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Regional Brain Activity During Rest and Gastric Water Load in Subtypes of Functional Dyspepsia: A Preliminary Brain Functional Magnetic Resonance Imaging Study

Chen Y, Wang R, Hou B, Feng F, Fang X, Zhu L, Sun X, Wang Z, Ke M

  • KMID: 2413103
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):268-279.
  • doi: 10.5056/jnm17076
BACKGROUND/AIMS: Functional dyspepsia (FD) remains a great clinical challenge since the FD subtypes, defined by Rome III classification, still have heterogeneous pathogenesis. Previous studies have shown notable differences in visceral...
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Dose-Dense Rituximab-CHOP versus Standard Rituximab-CHOP in Newly Diagnosed Chinese Patients with Diffuse Large B-Cell Lymphoma: A Randomized, Multicenter, Open-Label Phase 3 Trial

Li X, Huang H, Xu B, Guo H, Lin Y, Ye S, Yi J, Li W, Wu X, Wang W, Zhan H, Xie D, Peng J, Cao Y, Pu X, Guo C, Hong H, Wang Z, Fang X, Zhou Y, Lin S, Liu Q, Lin T

PURPOSE: Rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone administered every 3 weeks (R-CHOP-21) is the standard care for diffuse large B-cell lymphoma (DLBCL). It is unknown whether the dose-dense R-CHOP...
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