- Evaluation of Neutrophil Activation Status According to the Phenotypes of Adult Asthma
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Kim SH, Uuganbayar U, Trinh HK, Pham D, Kim N, Kim M, Sohn H, Park HS
- KMID: 2442049
- Allergy Asthma Immunol Res.
- 2019 May;11(3):381-393.
- doi: 10.4168/aair.2019.11.3.381
PURPOSE: Neutrophils are considered key effector cells in the pathogenic mechanisms of airway inflammation in asthma. This study assessed the activation status of neutrophils in adult asthmatics, and the therapeutic... -
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- Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery
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Park SJ, Im DS
- KMID: 2367621
- Biomol Ther.
- 2017 Jan;25(1):80-90.
- doi: 10.4062/biomolther.2016.160
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G... -
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- Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model
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Moon MH, Jeong JK, Lee JH, Park YG, Lee YJ, Seol JW, Park SY
- KMID: 1506224
- Exp Mol Med.
- 2012 Oct;44(10):603-614.
Higher levels of body fat are associated with an increased risk for development numerous adverse health conditions. FTY720 is an immune modulator and a synthetic analogue of sphingosine 1-phosphate (S1P),... -
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- FTY720: Mechanism of Action and Potential Benefit in Organ Transplantation
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Brinkmann
- KMID: 1726160
- Yonsei Med J.
- 2004 Dec;45(6):991-997.
- doi: 10.3349/ymj.2004.45.6.991
FTY720 is a novel immunomodulator that has proven effective in animal models of transplantation and autoimmunity, has achieved promising results in Phase I and Phase II studies of renal transplantation... -
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- Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells
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Lee WJ, Yoo HS, Suh PG, Lim JS, Oh S, Lee YM
- KMID: 1123763
- Exp Mol Med.
- 2004 Oct;36(5):420-427.
FTY720, a synthetic sphingoid base analog, was examined as a new sphingosine kinase inhibitor, which converts endogenous sphingosine into its phosphate form. With 20 micrometer of FTY720, sphingosine accumulated in... -
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