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Effect of Administering Freund's Complete Adjuvant to Spinal Nerves on the Development of Allodynia in the Rat

Park JY, Hwang JH

BACKGROUND: Spinal nerve ligation injury causes a neuropathic pain syndrome that includes allodynia. Neuropathic pain is also induced by Freund's complete adjuvant (FCA)-induced inflammation. This study was designed to examine...
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Comparison of the Antiallodynic Effects of Intrathecal Lidocaine and MK-801 on Mechanical Allodynia in Two Neuropathic Pain Rat Models

Cho SJ, Kang KN, Hwang JH

BACKGROUND: Neuropathic pain can be induced by nerve injury or inflammation. An N-methyl-D-Aspartate (NMDA) antagonist (MK-801), and a sodium channel blocker (lidocaine) have been found to reduce mechanical allodynia. This...
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Effect of Nitric Oxide on the Change of Spinal Neuropeptide in the Inflammation Model by Freund's Complete Adjuvant

Hwang SJ, Chung TJ, Shin DY, Hong HN, Leem JW, Hwang JH, Choi Y

  • KMID: 1559121
  • Korean J Anat.
  • 2001 Jun;34(3):293-302.
Injection of Freund's complete adjuvant (FCA) into the plantar surface of the rat induces inflammatory responses with accompanying pain behaviors. Signs of pain behaviors observed in FCA-injected animals are reported...
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Effect of Nitric Oxide on Neuropeptide Y Immunoreactivity in Rat Spinal Cord on the Allodynia of Inflammation Induced by Freund's Complete Adjuvant

Hwang SJ, Shin DY, Chung TJ, Kim MH, Hong HN, Choi Y

  • KMID: 1558767
  • Korean J Anat.
  • 2001 Dec;34(6):579-588.
Injection of Freund's complete adjuvant (FCA) into peripheral tissue induces inflammatory responses with accompanying pain behaviors. Injection of FCA produced a significant mechanical allodynia over time and nitric oxide(NO) is...
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A change of nitric oxide in rat DRG following Freund's Complete Adjuvant induced inflammtory pain

Hwang SJ, Lee JH, Chung TJ, Hong HN, Leem JW, Hwang JH, Choi Y

  • KMID: 2092722
  • Korean J Anat.
  • 2000 Apr;33(2):135-142.
It has been reported that injection of Freund's complete adjuvant (FCA) into the hindpaw of a rat induces inflammatory responses with accompanying pain behaviors. Signs of pain behaviors observed in...
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