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Anti-cancer effect of glabridin by reduction of extracellular vesicles secretion in MDA-MB-231 human breast cancer cells

Choi SH, Hwang JH, Baek MC, Cho YE

Purpose: Glabridin (GD) is a bio-available isoflavane isolated from the root extract of licorice (Glycyrrhiza glabra L.). It exhibits a variety of pharmacological activities such as antiinflammatory and anti-oxidant activities....
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Isolation and Characterization of Extracellular Vesicle from Mesenchymal Stem Cells of the Epidural Fat of the Spine

Sung SE, Seo MS, Kang KK, Choi JH, Lee SJ, Lim JH, Yang SY, Kim SK, Lee GW

Study Design: An experimental study with extracellular vesicles (EVs) from mesenchymal stem cell (MSC) of the epidural fat (EF) of the spine. Purpose: This study aims to isolate the exosomes from...
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Secretome of Stem Cells: Roles of Extracellular Vesicles in Diseases, Stemness, Differentiation, and Reprogramming

Kim HJ, Kim G, Lee J, Lee Y, Kim JH

Increasing evidence suggests that stem cells or stem cell-derived cells may contribute to tissue repair, not only by replacing lost tissue but also by delivering complex sets of secretory molecules,...
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Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles

Toyokuni S, Kong Y, Zheng H, Mi D, Katabuchi M, Motooka Y, Ito F

Human epidemiological and animal studies have demonstrated that excess iron is a risk for cancer. The responsible mechanisms are: 1) increased intracellular iron catalyzes the Fenton reaction to generate hydroxyl...
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Biomaterials-based Approaches for Cardiac Regeneration

Vasu S, Zhou J, Chen J, Johnston PV, Kim DH

The limited ability of cardiomyocytes to proliferate is a major cause of mortality and morbidity in cardiovascular diseases. There exist therapies for cardiac regeneration that are cell-based as well as...
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Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1a Signaling Pathway

Liu W, Yuan Y, Liu D

BACKGROUND: Impaired potential of hypoxia-mediated angiogenesis lead poor healing of diabetic wounds. Previous studies have shown that extracellular vesicles from adipose derived stem cells (ADSC-EVs) accelerate wound healing with unelucidated...
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The Antioxidant Effect of Small Extracellular Vesicles Derived from Aloe vera Peels for Wound Healing

Kim MK, Choi YC, Cho SH, Choi JS, Cho YW

Background: Extracellular vesicles (EVs) derived from plants have emerged as potential candidates for cosmetic and therapeutic applications. In this study, we isolated EVs from Aloe vera peels (A-EVs) and investigated the...
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Extracellular Vesicles in Regenerative Medicine: Potentials and Challenges

Lee JY, Kim HS

The ultimate goal of regenerative medicine is to regain or restore the damaged or lost function of tissues and organs. Several therapeutic strategies are currently being explored to achieve this...
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Helicobacter pylori-derived outer membrane vesicles stimulate interleukin 8 secretion through nuclear factor kappa B activation

Choi MS, Ze EY, Park JY, Shin TS, Kim JG

Background/Aims: Bacteria-derived outer membrane vesicles (OMVs) are commonly associated with various biological activities and functions. Helicobacter pylori-derived OMVs are thought to contribute to pathogenesis. This study aimed to investigate the...
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Extracellular vesicles in kidneys and their clinical potential in renal diseases

Lee SA, Choi C, Yoo TH

Extracellular vesicles (EVs), such as exosomes and microvesicles, are cell-derived lipid bilayer membrane particles, which deliver information from host cells to recipient cells. EVs are involved in various biological processes...
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Extracellular Vesicles and Immune System in Ageing and Immune Diseases

Cheon SY, Lee JE

Immune system is essential for host homeostasis. Immune cells communicate with each other by binding to receptors or by releasing vesicles including chemokines and cytokines. Under healthy circumstances, immune cell-derived...
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Urinary Extracellular Vesicles as Biomarkers of Kidney Disease

Sun IO

Extracellular vesicles (EVs) are membrane-bound vesicles produced and released into the extracellular fluid by cells under physiological and stressful conditions. They play a role as intracellular communicators by carrying and...
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Novel Marine Organism-Derived Extracellular Vesicles for Control of Anti-Inflammation

Jo SH, Kim C, Park SH

BACKGROUND: Extracellular vesicles (EVs) exhibit potential as functional biomolecules for tissue regeneration and immunomodulation as they play important roles in the physiological communication between cells. EV internal cargo contains miRNAs,...
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The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future

Watanabe Y, Tsuchiya A, Terai S

Cirrhosis is a chronic condition that can lead to liver failure. Currently, the viable option for decreasing mortality is liver transplantation. However, transplant surgery is highly invasive. Therefore, cell-based therapy...
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Liquid biopsy using extracellular vesicle–derived DNA in lung adenocarcinoma

Kim IA, Hur JY, Kim HJ, Lee SE, Kim WS, Lee KY

Blood liquid biopsy has emerged as a way of overcoming the clinical limitations of repeat biopsy by testing for the presence of acquired resistance mutations to therapeutic agents. Despite its...
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Lung Disease Diagnostic Model Through IgG Sensitization to Microbial Extracellular Vesicles

Yang J, Hong G, Kim YS, Seo H, Kim S, McDowell A, Lee WH, Kim YS, Oh YM, Cho YS, Choi YW, Kim YY, Jee YK, Kim YK

Purpose: Recently, there has been a rise in the interest to understand the composition of indoor dust due to its association with lung diseases such as asthma, chronic obstructive pulmonary...
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Diabetes and Viral Diseases

Kim S

Patients with diabetes are more susceptible to viral diseases, which are more likely to progress to severe cases in such patients. Diabetes and hyperglycemia have been reported to be major...
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Advantages of the outgrowth model for evaluating the implantation competence of blastocysts

Kim J, Lee J, Jun JH

The implantation process is highly complex and difficult to mimic in vitro, and a reliable experimental model of implantation has yet to be established. Many researchers have used embryo transfer...
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Therapeutic potential of stem cell-derived extracellular vesicles in osteoarthritis: preclinical study findings

Kim KH, Jo JH, Cho HJ, Park TS, Kim TM

Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeutic purposes, stem cell-derived...
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Application of Stem Cell-Derived Extracellular Vesicles in Allergic Airway Diseases

Kim SD, Cho KS

Mesenchymal stem cells (MSCs) have been reported to be promising candidates for the treatment of allergic airway diseases. However, MSCs themselves have several problems including immune rejection, risk of aneuploidy,...
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