- Survive or thrive: tradeoff strategy for cellular senescence
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Park SC
- KMID: 2386962
- Exp Mol Med.
- 2017 Jun;49(6):e342.
- doi: 10.1038/emm.2017.94
Aging-dependent cellular behaviors toward extrinsic stress are characterized by the confined localization of certain molecules to either nuclear or perinuclear regions. Although most growth factors can activate downstream signaling in... -
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- Rhododendrin inhibits toll-like receptor-7-mediated psoriasis-like skin inflammation in mice
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Jeon YJ, Sah SK, Yang HS, Lee JH, Shin J, Kim TY
- KMID: 2386969
- Exp Mol Med.
- 2017 Jun;49(6):e349.
- doi: 10.1038/emm.2017.81
Many active compounds present in Rhododendron brachycarpum have been used in traditional Oriental medicine for the treatment of various skin diseases. However, the precise mechanism of action of the compounds... -
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- Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
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Lou G, Chen Z, Zheng M, Liu Y
- KMID: 2386966
- Exp Mol Med.
- 2017 Jun;49(6):e346.
- doi: 10.1038/emm.2017.63
The administration of mesenchymal stem cells (MSCs) as a therapy for liver disease holds great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote hepatic regeneration and secrete protective... -
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- Effects of chronic alcohol exposure on ischemia–reperfusion-induced acute kidney injury in mice: the role of β-arrestin 2 and glycogen synthase kinase 3
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Wang L, Zhu Y, Wang L, Hou J, Gao Y, Shen L, Zhang J
- KMID: 2386967
- Exp Mol Med.
- 2017 Jun;49(6):e347.
- doi: 10.1038/emm.2017.76
Little is known about the effects of chronic alcohol intake on the outcome of acute kidney injury (AKI). Hence, we examined the effects of chronic alcohol intake on the development... -
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- Protein tyrosine phosphatase 1B is a mediator of cyclic ADP ribose-induced Ca²⺠signaling in ventricular myocytes
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Park SA, Hong BZ, Ha KC, Kim UH, Han MK, Kwak YG
- KMID: 2386961
- Exp Mol Med.
- 2017 Jun;49(6):e341.
- doi: 10.1038/emm.2017.68
Cyclic ADP-ribose (cADPR) releases Ca²⺠from ryanodine receptor (RyR)-sensitive calcium pools in various cell types. In cardiac myocytes, the physiological levels of cADPR transiently increase the amplitude and frequency of... -
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- Upregulation of mitochondrial NAD⺠levels impairs the clonogenicity of SSEA1⺠glioblastoma tumor-initiating cells
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Son MJ, Ryu JS, Kim JY, Kwon Y, Chung KS, Mun SJ, Cho YS
- KMID: 2386964
- Exp Mol Med.
- 2017 Jun;49(6):e344.
- doi: 10.1038/emm.2017.74
Emerging evidence has emphasized the importance of cancer therapies targeting an abnormal metabolic state of tumor-initiating cells (TICs) in which they retain stem cell-like phenotypes and nicotinamide adenine dinucleotide (NADâº)... -
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- Elevated TRAF4 expression impaired LPS-induced autophagy in mesenchymal stem cells from ankylosing spondylitis patients
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Li J, Wang P, Xie Z, Yang R, Li Y, Wu X, Su H, Deng W, Wang S, Liu Z, Cen S, Ouyang Y, Wu Y, Shen H
- KMID: 2386963
- Exp Mol Med.
- 2017 Jun;49(6):e343.
- doi: 10.1038/emm.2017.69
Ankylosing spondylitis (AS) is a type of autoimmune disease that predominantly affects the spine and sacroiliac joints. However, the pathogenesis of AS remains unclear. Some evidence indicates that infection with... -
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- Lineage conversion of mouse fibroblasts to pancreatic α-cells
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Liu T, Sun L, Jiang B, Li L, Cen J, Chen X, Zhang Z, Wang Q, Cheng X, Shi Y, Hui L
- KMID: 2386970
- Exp Mol Med.
- 2017 Jun;49(6):e350.
- doi: 10.1038/emm.2017.84
α-cells, which synthesize glucagon, also support β-cell survival and have the capacity to transdifferentiate into β-cells. However, the role of α-cells in pathological conditions and their putative clinical applications remain... -
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- Upregulation of miR-223 in the rat liver inhibits proliferation of hepatocytes under simulated microgravity
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Chen Y, Xu J, Yang C, Zhang H, Wu F, Chen J, Li K, Wang H, Li Y, Li Y, Dai Z
- KMID: 2386968
- Exp Mol Med.
- 2017 Jun;49(6):e348.
- doi: 10.1038/emm.2017.80
Long-term spaceflight affects numerous organ systems in the body, including metabolic dysfunction. Recently, ample evidence has demonstrated that the liver is a vulnerable organ during spaceflight. However, the changes in... -
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- Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits
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Bárcena-Varela S, MartÃnez-de-Tejada G, Martin L, Schuerholz T, Gil-Royo A, Fukuoka S, Goldmann T, Droemann D, Correa W, Gutsmann T, Brandenburg K, Heinbockel L
- KMID: 2386965
- Exp Mol Med.
- 2017 Jun;49(6):e345.
- doi: 10.1038/emm.2017.75
Sepsis, which is induced by severe bacterial infections, is a major cause of death worldwide, and therapies combating the disease are urgently needed. Because many drugs have failed in clinical... -
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