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Pathophysiological Role of Endothelin-1 and Clinical Usefulness of Endothelin Antagonists

Seo B

No abstract available.
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A study of contractile effect of endothelin-1 in rat tracheal smooth muscle

In KH, Kang KH, Yoo SH

  • KMID: 1698131
  • Korean J Intern Med.
  • 1992 May;42(5):630-638.
No abstract available.
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Endothelin-l Content of Bronchoalveolar Lavage in Allografted Lungs during Acute Rejection

Park YS

OBJECTIVE: The aim of this study was to investigate whether or not endothelin-1 content of bronchoalveolar lavage was elevated in allografted lungs during acute rejection. METHODS: After single lung allotransplantation, dogs...
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Effect of endothelin-1 on proliferation and differentiation of rat tracheal epithelial cells

Kim CS, Oh SO, Woo JS, Jung JS, Kim YK, Lee SH

  • KMID: 2071835
  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):763-770.
A number of substances involved in the proliferation and differentiation of the tracheobronchial epithelium have been identified. The defects in the control of the proliferation and differentiation of tracheobronchial epithelial cells appear to constitute...
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The endothelin-1 expression in the kidney tissue of patients with glomerulonephritis

Bae SJ, An WS, Rha SH, Kim SE, Kim KH

  • KMID: 1866914
  • Korean J Med.
  • 2002 May;62(5):530-536.
BACKGROUND: Endothelin-1 has been found to be a potent mitogen in cultured mesangial cells. In addition, the urinary hyperexcretion of endothelin-1 was observed in patients with glomerulonephritis. METHODS: The author studied...
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Quantification of endothelin-1 in human umbilical venous endothelial cell culture supernatants of small for gestational age and preeclampsia neonates

Cho WK, Kim SY, Chun CS

PURPOSE: It was generally accepted now a days that the pathogenesis of preeclampsia, small for gestational age (SGA), intrauterine growth retardation and fetal origin of adult diseases were related with...
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Endothelin-1, Endothelin-2 and Endothelin-3 Induced Expression of Monocyte Chemoattractant Protein-1 in Rat Mesangial Cells

Shin MJ, Kim HW, Yang CW, Kim YS, Kim SY, Choi EJ, Chang YS, Bang BK

  • KMID: 1610169
  • Korean J Nephrol.
  • 2003 Jul;22(4):358-365.
BACKGROUND: Monocyte chemoattractant protein- 1 (MCP-1) is an important mediator for monocyte/ macrophage infiltration in various inflammatory renal diseases and is produced by renal cells. In the process of renal...
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Changes of Plasma Endothelin-1 Concentration after Percutaneous Mitral Commissurotomy

Zo JH, Oh BH, Koo SH, Nam GB, Lee DS, Kim HS, Sohn DW, Kim CH, Lee MM, Park YB, Choi YS, Seo JD, Lee YW

BACKGROUND: Endothelin, a very potent vasoconstricting substance released from the endothelium, has been known to be elevated in various cardiovascular disorders, however, the sites of endothelin porduction as well as...
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Expression of Endothelin-1 and Its Receptors in Cisplatin-Induced Acute Renal Failure in Mice

Lee S, Ahn D

Endothelin-1 (ET-1) is unequivocally elevated in the kidney with ischemic acute renal failure (ARF), whereas ET receptors (ET(A)R and ET(B)R) are variably expressed. Although renal functional and structural changes are...
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The Effect of Endothelin on Osteoblast

Jeon HS, Kim YT, Chang JS, Kim KY, Yoon HK, Kim CY

  • KMID: 2141816
  • J Korean Orthop Res Soc.
  • 1998 Apr;1(1):1-13.
Endothelin derived from the endothelial cells of microvessel is a potent vasoactive peptide, which has various physiologic actions in many internal organs. The fact that endothelin receptors are present on...
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Effects of Dexamethasone on Endothelin-1(ET-1) Production by Keratinocytes

Lee IW, Lee SC, Kim DS, Kim HJ, Park KC

Epidermal keratinocytes are important sources of a wide variety of cytokines that include the endothelin-1 (ET-1). Glucocorticoids have been shown to inhibit the production of several cytokines. However, their effect...
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Scanning Electron Microscopic Observation on the Microvasculature in Anterior Segment of the Rabbit Eye Injected with Endothelin-1

Park EK, Lee JH, Yoo JM

  • KMID: 2123677
  • J Korean Ophthalmol Soc.
  • 1997 Aug;38(8):1336-1341.
Using Mercox CL-2B, intravascular casting was performed follwoing intracameral injection with 2.0microgram/microliter of Endothelin-1(ET-1) in the rabbit eye. One hour after intracameral injection with ET-1 caused severe focal andsegmental constriction...
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The Role of Endothelin-1 in Obstructive Sleep Apnea Syndrome and Pulmonary Hypertension

Choi Y

  • KMID: 2317493
  • Sleep Med Psychophysiol.
  • 2010 Dec;17(2):69-74.
Obstructive sleep apnea syndrome is associated with significant cardiovascular morbidity and increased mortality. However, it was controversial whether obstructive sleep apnea syndrome could cause pulmonary hypertension. The controversy was resolved...
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Changes of Endothelin-1 Level after the Closure of Patent Ductus Arteriosus

Won YS

OBJECTIVES: Pulmonary hypertension is characterized by an increase in vascular tone of an abnormal proliferation of muscle cells in the wall of small pulmonary arteries. Endothelin-1(ET-1) is a potent endothelium-derived...
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The Acute Effect of Estrogen on Vascular Responses and Plasma Endothelin-1 Level in Postmenopausal Women

Kang JH, Kim BS, Lee YW, Keum DG, Jung HW, Lee HS, Lee MH, Park JR

BACKGROUND AND OBJECTIVES: Although estrogen replacement therapy has been associated with reduction of cardiovascular events in postmeno-pausal women (PMW), the underlying mechanisms are pooly understood. Because the beneficial effect of...
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Can Peritoneal Dialysis Remove Endothelin-1 after Cardiopulmonary Bypass for Repair of Congenital Heart Disease?

Chang YH, Sung SC, Ban JE, Lee HD, Lee SH, Rhym BY

  • KMID: 1916502
  • Korean J Thorac Cardiovasc Surg.
  • 2007 Apr;40(4):247-255.
BACKGROUND: Lung injury that follows bypass has been well described. It is manifested as reduced oxygenation and lung compliance and, most importantly, increased pulmonary vascular resistance reactivity; this is a...
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The Effect of Endothelin-1 on IOP and Aqueous Outflow Facility in the Rabbit Eye

Jwa WB, Yoo KW, Rho SH

  • KMID: 2147776
  • J Korean Ophthalmol Soc.
  • 1996 Jan;37(1):129-135.
Endothelin(ET) is known as a family of potent hydrophobic, vasoactive peptide. We investigated the effect according to the concentrations of ET on intraocular pressure(IOP), aqueous outflow facility, pupillary diameter and...
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Endoperoxides and Thromboxane A2 in Porcine Coronary Arteries with Regenerated Endothelium

Kim JJ, Park SJ, Lee JK, Lee YW

BACKGROUND: Endothelin-1 is a potent vasoconstrictor substance that causes slow and longlasting contractions of isolated blood vessels. In the aorta of the spontaneously hypertensive rat, endothelin-1 stimulates the release of...
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Increased plasma endothelin-1 and abnormal nailfold capillaroscopic findings in patients with connective tissue diseases

Do JH, Kim HY

  • KMID: 1867066
  • Korean J Med.
  • 2004 Mar;66(3):275-283.
BACKGROUND: Since the endothelin-1 may be implicated in the pathogenesis of peripheral vascular diseases associated with connective tissue diseases (CTDs), we examined the plasma endothelin-1 level in association with quantitative...
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The Role of Plasma Endothelin-1 in Fluid-Electrolyte Balance and Renal Function in Patients with Liver Cirrhosis

Lee J, Park CS, Park CH, Kae SH, Kwak ST, Joo SA, Kim HJ, Kee CS

  • KMID: 2080488
  • Korean J Med.
  • 1997 Apr;52(4):476-489.
OBJECTIVES: It has been recently known that endotheUn-1 is a potent vasoconstrictor. The purpose of the present study was to clarify the possible correlation of endothelin-1 with other vasoactive neurohormonal...
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