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Identification of Protein Z as a Potential Novel Biomarker for the Diagnosis of Prediabetes

Koo SH

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Urinary Free Metanephrines for Diagnosis of Pheochromocytoma and Paraganglioma

Ahn J, Park JY, Kim G, Jin SM, Hur KY, Lee SY, Kim JH

Background: Pheochromocytoma and paraganglioma (PPGL) is diagnosed through biochemical confirmation of excessive catecholamines in urine and plasma. Recent technological developments have allowed us to measure urinary free metanephrines; however, the...
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Antithyroid Drug Treatment in Graves’ Disease

Chung JH

Graves’ disease is associated with thyrotropin (TSH) receptor stimulating antibody, for which there is no therapeutic agent. This disease is currently treated through inhibition of thyroid hormone synthesis or destruction...
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Normocalcemic Primary Hyperparathyroidism: Need for a Standardized Clinical Approach

Zavatta G, Clarke BL

Since normocalcemic primary hyperparathyroidism (NHPT) was first defined at the Third International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism in 2008, many papers have been published describing its prevalence...
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Subclinical Hypothyroidism: Prevalence, Health Impact, and Treatment Landscape

Yoo WS, Chung HK

Subclinical hypothyroidism (sHypo) is defined as normal serum free thyroid hormone levels coexisting with elevated serum thyroid-stimulating hormone (TSH) levels. sHypo is a common condition observed in clinical practice with...
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Long-Term Treatment of Postmenopausal Osteoporosis

Brown JP

Osteoporosis is an incurable chronic condition, like heart disease, diabetes, or hypertension. A large gap currently exists in the primary prevention of fractures, and studies show that an estimated 80%...
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Heart Rate Variability in Postoperative Patients with Nonfunctioning Pituitary Adenoma

Ha J, Baek H, Jeong C, Yeo M, Lee SH, Cho JH, Baek KH, Kang MI, Lim DJ

Background: Decreased heart rate variability (HRV) has been reported to be associated with cardiac autonomic dysfunction. Hypopituitarism in nonfunctioning pituitary adenoma (NFPA) is often linked to increased cardiovascular mortality. We...
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Descriptive Epidemiology and Survival Analysis of Prolactinomas and Cushing’s Disease in Korea

Park JS, Yun SJ, Lee JK, Park SY, Chin SO

Background: Only a few studies have established the epidemiology of prolactinoma and Cushing’s disease in Korea. Furthermore, the incidence of these disease are increasing than before associated with the development...
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Efficacy and Safety of the New Appetite Suppressant, Liraglutide: A Meta-Analysis of Randomized Controlled Trials

Moon S, Lee J, Chung HS, Kim YJ, Yu JM, Yu SH, Oh CM

Background: Obesity is a chronic disease associated with metabolic diseases such as diabetes and cardiovascular disease. Since the U.S. Food and Drug Administration approved liraglutide as an anti-obesity drug for...
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Asian Conference on Tumor Ablation Guidelines for Adrenal Tumor Ablation

Park BK, Fujimori M, Shen SH, Pua U

Thermal ablation is a good alternative treatment in patients who are unable to undergo adrenalectomy. Even though the Asian Conference on Tumor Ablation (ACTA) has been held for many years,...
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Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020

Jang JH, Kwon O, Moon SJ, Jeong YT

Taste sensation is the gatekeeper for direct decisions on feeding behavior and evaluating the quality of food. Nutritious and beneficial substances such as sugars and amino acids are represented by...
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Expression of LONP1 Is High in Visceral Adipose Tissue in Obesity, and Is Associated with Glucose and Lipid Metabolism

Lee JH, Jung SB, Lee SE, Kim JE, Kim JT, Kang YE, Kang SG, Yi HS, Ko YB, Lee KH, Ku BJ, Shong M, Kim HJ

Background: The nature and role of the mitochondrial stress response in adipose tissue in relation to obesity are not yet known. To determine whether the mitochondrial unfolded protein response (UPRmt)...
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Current Guidelines for Management of Medullary Thyroid Carcinoma

Kim M, Kim BH

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from the parafollicular cells. The diagnostic and therapeutic strategies for the condition are different from those used for well-differentiated thyroid...
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Cushing Syndrome Associated Myopathy: It Is Time for a Change

Reincke M

Cushing syndrome is the result of excessive levels of glucocorticoids. Endogenous Cushing syndrome is rare with an incidence of two to three cases per million per year. Clinically, the presentation...
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Update on Glucocorticoid Induced Osteoporosis

Cho SK, Sung YK

Glucocorticoids are used to treat many autoimmune and inflammatory diseases. However, an adverse systemic effect is a deleterious effect on bone, which may lead to glucocorticoid-induced osteoporosis, characterized by a...
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Clinicopathological Characteristics and Recurrence-Free Survival of Rare Variants of Papillary Thyroid Carcinomas in Korea: A Retrospective Study

Kim M, Cho SW, Park YJ, Ahn HY, Kim HS, Suh YJ, Choi D, Kim BK, Yang GE, Park IS, Yi KH, Jung CK, Kim BH

Background: We aimed to evaluate the clinicopathological features and biological behaviors of Korean thyroid cancer patients with rare variants of papillary thyroid carcinoma (PTC) to address the ambiguity regarding the...
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Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics

Yoon JH, Kwon KS

Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement...
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Evaluation of Iodine Status among Korean Patients with Papillary Thyroid Cancer Using Dietary and Urinary Iodine

Choi JY, Lee JH, Song Y

Background: Concerns have been raised regarding thyroid disorders caused by excessive iodine in Koreans, who have iodine-rich diets. This study evaluated iodine status using dietary iodine intake and urinary iodine...
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Effect of Cigarette Smoking on Thyroid Cancer: Meta-Analysis

Lee JH, Chai YJ, Yi KH

Background: Although smoking is generally carcinogenic, its effect on thyroid cancers is still subject to controversy. The purpose of this study was to summarize the role of smoking in relation...
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Association of Protein Z with Prediabetes and Type 2 Diabetes

Bae YU, You JH, Cho NH, Kim LE, Shim HM, Park JH, Cho HC

Background: Type 2 diabetes mellitus (T2DM) is a progressive metabolic disease. Early detection of prediabetes is important to reduce the risk of T2DM. Some cytokines are known to be associated...
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