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Why Do We Need Proactive Management for Fracture Prevention in Long-Term Glucocorticoid Users?

Choi HS

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Association between Serum Free Thyroxine and Anemia in Euthyroid Adults: A Nationwide Study (Endocrinol Metab 2020;35:106-14, Mijin Kim et al.)

Kim M, Kim BH

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Systems Biology: A Multi-Omics Integration Approach to Metabolism and the Microbiome

Son JW, Shoaie S, Lee S

The complex and dynamic nature of human physiology, as exemplified by metabolism, has often been overlooked due to the lack of quantitative and systems approaches. Recently, systems biology approaches have...
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Lessons from Use of Continuous Glucose Monitoring Systems in Digital Healthcare

Kim HS, Yoon KH

We live in a digital world where a variety of wearable medical devices are available. These technologies enable us to measure our health in our daily lives. It is increasingly...
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Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study

Kim JD, Lim DM, Park KY, Park SE, Rhee EJ, Park CY, Lee WY, Oh KW

Background: It is well known that high serum ferritin, a marker of iron storage, predicts incident type 2 diabetes. Limited information is available on the association between transferrin, another marker...
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Predicting the Development of Myocardial Infarction in Middle-Aged Adults with Type 2 Diabetes: A Risk Model Generated from a Nationwide Population-Based Cohort Study in Korea

Lee SH, Han K, Kim HS, Cho JH, Yoon KH, Kim MK

Background: Most of the widely used prediction models for cardiovascular disease are known to overestimate the risk of this disease in Asians. We aimed to generate a risk model for...
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Erratum: Correction of Figure. Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A

Shong KE, Oh CM, Namkung J, Park S, Kim H

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Relationship of Sarcopenia with Microcirculation Measured by Skin Perfusion Pressure in Patients with Type 2 Diabetes

Jung CH, Cho YY, Choi D, Kim BY, Kim CH, Mok JO

Background: Few studies have examined the relationship of sarcopenia with the microcirculation. The current study investigated the relationship of sarcopenia with microcirculatory function, as assessed by skin perfusion pressure (SPP),...
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Corrigendum: IRB Approval Number Correction. Cardiac Dysfunction in Association with Increased Inflammatory Markers in Primary Aldosteronism

Lim JS, Park S, Park SI, Oh YT, Choi EH, Kim JY, Rhee Y

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Clinical Implication of World Health Organization Classification in Patients with Follicular Thyroid Carcinoma in South Korea: A Multicenter Cohort Study

Jin M, Kim ES, Kim BH, Kim HK, Yi HS, Jeon MJ, Kim TY, Kang HC, Kim WB, Shong YK, Kim M, Kim WG

Background: The study aimed to compare the prognostic value of the 4th edition of World Health Organization classification (WHO-2017) with the previous WHO classification (WHO-2004) for follicular thyroid carcinoma (FTC). Methods:...
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The Prevalence and Risk of Type 2 Diabetes in Adults with Disabilities in Korea

Jung I, Kwon H, Park SE, Han KD, Park YG, Rhee EJ, Lee WY

Background: People with disabilities are at risk of secondary conditions such as diabetes. The aim of this study was to evaluate the prevalence and risk of type 2 diabetes in...
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Current National and International Guidelines for the Management of Male Hypogonadism: Helping Clinicians to Navigate Variation in Diagnostic Criteria and Treatment Recommendations

Al-Sharefi A, Quinton R

Male hypogonadism—rebadged by some as testosterone deficiency syndrome—is a clinical and biochemical diagnosis of increasing worldwide interest. Organic male hypogonadism—usually permanent—is well-established, but aging men may also exhibit lower serum...
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WD40-Repeat Proteins in Ciliopathies and Congenital Disorders of Endocrine System

Kim Y, Kim SH

WD40-repeat (WDR)-containing proteins constitute an evolutionarily conserved large protein family with a broad range of biological functions. In human proteome, WDR makes up one of the most abundant protein-protein interaction...
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Stimulated Salivary Cortisol as a Noninvasive Diagnostic Tool for Adrenal Insufficiency

Kim YJ, Kim JH, Hong AR, Park KS, Kim SW, Shin CS, Kim SY

Background: Salivary cortisol is routinely used as a diagnostic test for Cushing syndrome. The diagnostic use of salivary cortisol for adrenal insufficiency (AI), however, is less established. We aimed to...
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Liver X Receptor β Related to Tumor Progression and Ribosome Gene Expression in Papillary Thyroid Cancer

Jeong S, Kim IK, Kim H, Choi MJ, Lee J, Jo YS

Background: Intracellular lipid deposition has been reported in thyroid glands in obese animal and human. To understand the regulatory mechanism of lipid metabolism in thyroid cancer, we investigated the expression...
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Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E

Song YS, Park YJ

The telomerase reverse transcriptase (TERT) gene, which is repressed in most differentiated human cells, can be reactivated by somatic TERT alterations and epigenetic modulations. Moreover, the recruitment, accessibility, and binding...
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Metabolically Healthy and Unhealthy Normal Weight and Obesity

Stefan N

Increased fat mass is an established risk factor for the cardiometabolic diseases type 2 diabetes and cardiovascular disease (CVD) and is associated with increased risk of all-cause and CVD mortality....
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A Phase II Multi-Center, Non-Randomized, Parallel Group, Non-Inferiority Study to Compare the Efficacy of No Radioactive Iodine Remnant Ablation to Remnant Ablation Treatment in Low- to Intermediate-Risk of Papillary Thyroid Cancer: The MOREthyroid Trial Protocol

Background: Radioactive iodine (RAI) remnant ablation is recommended in patients with papillary thyroid cancer (PTC) and extrathyroidal extension or central lymph node metastasis. However, there exists little evidence about the...
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Irisin Regulates the Functions of Hepatic Stellate Cells

Dong HN, Park SY, Le CT, Choi DH, Cho EH

Background: Hepatic stellate cells (HSCs) are known to play a fundamental role in the progression of liver fibrosis. Once HSCs are activated, they are involved in proliferation, migration, and contractility...
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Clinical Outcomes of N1b Papillary Thyroid Cancer Patients Treated with Two Different Doses of Radioiodine Ablation Therapy

Jin M, Ahn J, Lee YM, Sung TY, Kim WG, Kim TY, Ryu JS, Kim WB, Shong YK, Jeon MJ

Background: The optimal dose of radioactive iodine (RAI) therapy for N1b papillary thyroid carcinoma (PTC) is controversial. We evaluated the clinical outcome of N1b PTC patients treated with either 100...
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