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Articles in 'Endocrinology and Metabolism' in 2014

Lee WY

No abstract available.
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Metformin-Associated Lactic Acidosis

Suh S

No abstract available.
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Erratum: Figure Correction: Standardized Thyroid Cancer Mortality in Korea between 1985 and 2010

Choi YM, Kim TY, Jang EK, Kwon H, Jeon MJ, Kim WG, Shong YK, Kim WB

Corrections for Figure 2 in page 534 are needed. The bar graphs of male and female are drawn as same graphs.
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Clinical Guidelines for the Diagnosis and Treatment of Cushing's Disease in Korea

Hur KY, Kim JH, Kim BJ, Kim MS, Lee EJ, Kim SW

Cushing's disease (CD) is a rare disorder characterized by the overproduction of adrenocorticotropic hormone due to a pituitary adenoma that ultimately stimulates excessive cortisol secretion from the adrenal glands. Prior...
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Update on Denosumab Treatment in Postmenopausal Women with Osteoporosis

Min YK

Denosumab, a fully human recombinant monoclonal antibody to the receptor activator of nuclear factor-kappaB ligand (RANKL), blocks binding of RANKL to the RANK receptor, found on the surface of osteoclasts...
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Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves' Disease

Hwang IK, Kim SH, Lee U, Chin SO, Rhee SY, Oh S, Woo JT, Kim SW, Kim YS, Chon S

Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a gluten-containing diet in genetically susceptible individuals. The genetic predisposition is related to human leukocyte antigen (HLA) class II...
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Metformin-Associated Lactic Acidosis: Predisposing Factors and Outcome

Kim MJ, Han JY, Shin JY, Kim SI, Lee JM, Hong S, Kim SH, Nam MS, Kim YS

BACKGROUND: Metformin is considered the first choice oral treatment for type 2 diabetes patients in the absence of contraindications. Rarely, life-threatening complications associated with metformin treatment are seen in some...
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A Closer Look at Papillary Thyroid Carcinoma

Kim WB

Recent surge of thyroid cancer, especially papillary thyroid carcinoma (PTC), ignited a debate on over-diagnosis of cancer. Such increase in incidence is a worldwide phenomenon, but it has been the...
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Multiple Myeloma in a Patient with Acromegaly

Kang YM, Choi JH, Lee MJ, Ahn A, Park CJ, Chang K, Seo S, Hong SI, Kim MS

Acromegaly is a slowly progressing condition resulting from excess growth hormone (GH), generally caused by a GH-secreting pituitary adenoma. Cancer is the third most common cause of mortality in patients...
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Determination of Mother Centriole Maturation in CPAP-Depleted Cells Using the Ninein Antibody

Lee M, Rhee K

BACKGROUND: Mutations in centrosomal protein genes have been identified in a number of genetic diseases in brain development, including microcephaly. Centrosomal P4.1-associated protein (CPAP) is one of the causal genes...
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Risk of Malignancy in Thyroid Incidentalomas Identified by Fluorodeoxyglucose-Positron Emission Tomography

Chun AR, Jo HM, Lee SH, Chun HW, Park JM, Kim KJ, Jung CH, Mok JO, Kang SK, Kim CH, Kim BY

BACKGROUND: Thyroid incidentalomas detected by 2-deoxy-2-18F-fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) have been reported in 1% to 4% of the population, with a risk of malignancy of 27.8% to...
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The Risks and Benefits of Calcium Supplementation

Shin CS, Kim KM

The association between calcium supplementation and adverse cardiovascular events has recently become a topic of debate due to the publication of two epidemiological studies and one meta-analysis of randomized controlled...
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NF-kappaB-Mediated Regulation of Osteoclastogenesis

Boyce BF, Xiu Y, Li J, Xing L, Yao Z

Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusion of bone marrow-derived myeloid lineage precursors that circulate in the blood. Major advances in understanding...
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Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder

Yang H, Huh SO, Hong JS

BACKGROUND: Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. This study evaluated the effect of methyl-6-(phenylethynyl)-pyridine (MPEP), an...
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Optimal Candidates for the Switch from Glimepiride to Sitagliptin to Reduce Hypoglycemia in Patients with Type 2 Diabetes Mellitus

Kim HM, Lim JS, Lee BW, Kang ES, Lee HC, Cha BS

BACKGROUND: Sitagliptin is a novel antidiabetic agent with a low risk for hypoglycemia. We investigated the efficacy and safety of sitagliptin when patients switched from a sulfonylurea to sitagliptin and...
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Co-Culture of alpha TC-6 Cells and beta TC-1 Cells: Morphology and Function

Kim SM, Lee EJ, Jung HS, Han N, Kim YJ, Kim TK, Kim TN, Kwon MJ, Lee SH, Park JH, Rhee BD, Kim MK

BACKGROUND: In vitro experiments using only beta-cell lines instead of islets are limited because pancreatic islets are composed of four different types of endocrine cells. Several recent studies have focused...
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Increased Sclerostin Levels after Further Ablation of Remnant Estrogen by Aromatase Inhibitors

Kim W, Chung Y, Kim SH, Park S, Bae JH, Kim G, Lee SJ, Kim JE, Park BW, Lim SK, Rhee Y

BACKGROUND: Sclerostin is a secreted Wnt inhibitor produced almost exclusively by osteocytes, which inhibits bone formation. Aromatase inhibitors (AIs), which reduce the conversion of steroids to estrogen, are used to...
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Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse beta-Cells

Kim MJ, Choi OK, Chae KS, Kim MK, Kim JH, Komatsu M, Tanaka K, Lee H, Chung SS, Kwak SH, Cho YM, Park KS, Jung HS

BACKGROUND: Damaged mitochondria are removed by autophagy. Therefore, impairment of autophagy induces the accumulation of damaged mitochondria and mitochondrial dysfunction in most mammalian cells. Here, we investigated mitochondrial function and...
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