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Genetic Variations of ABCC2 Gene Associated with Adverse Drug Reactions to Valproic Acid in Korean Epileptic Patients

Yi JH, Cho YJ, Kim WJ, Lee MG, Lee JH

The multidrug resistance protein 2 (MRP2, ABCC2) gene may determine individual susceptibility to adverse drug reactions (ADRs) in the central nervous system (CNS) by limiting brain access of antiepileptic drugs,...
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Data Analysis for Anti-Neoplastic Chemotherapy-Related Adverse Events Reported to the Korean Pharmacovigilance Regional Network

Lee JY, Jung JW, Kang HR, Lee SH, Kim HS, Cho SH

  • KMID: 2267789
  • Korean J Med.
  • 2013 Oct;85(4):385-395.
BACKGROUND/AIMS: To describe the toxicity profile of anti-neoplastic agents from real clinical settings, we analyzed spontaneously reported adverse events (AEs) using data from the adverse drug reaction (ADR) reporting system...
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Very Early Onset of Amiodarone-Induced Pulmonary Toxicity

Lee W, Ryu DR, Han SS, Ryu SW, Cho BR, Kwon H, Kim BR

Amiodarone is a widely used antiarrhythmic agent. Among its various adverse effects, amiodarone-induced pulmonary toxicity (APT) is the most life threatening complication, which has been described mostly in patients who...
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Anaphylaxis due to fentanyl during radiofrequency ablation

Kim JY, Om SY, Yoon SY, Kim TB, Cho YS, Moon HB, Kwon HS

This case report describes a life-threatening anaphylaxis to fentanyl during radiofrequency ablation (RFA). A 50-year-old woman with hepatocellular carcinoma was admitted for RFA. She denied any history of adverse drug...
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Amiodarone-Induced Pulmonary Toxicity: Percutaneous Needle Aspiration Biopsy and Ultrastructural Findings

Kang IS, Lee JH, Sung SH, Park SH

Amiodarone has been widely used for supraventricular and ventricular arrhythmias and many patients benefit from its effectiveness in treating potentially life-threatening arrhythmias. However, this drug can cause multi-organ toxicity, including...
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Safety and Efficacy of Modern Insulin Analogues

Yoo HJ, Park KY, Park KS, Ahn KJ, Min KW, Park JH, Chang SA, Cha BS, Kim DJ, Kim YS, Oh TK, Chon S, Nam-Goong , Kim MJ, Kim HS, Choi YS, Ahn YH, Lee S, Baik SH

BACKGROUND: A1chieve(R) was a noninterventional study evaluating the clinical safety and efficacy of biphasic insulin aspart 30, insulin detemir, and insulin aspart. METHODS: Korean type 2 diabetes patients who have not...
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Zolpidem, Is it a Safe Drug for Insomnia Management?

Park KH, Lee JH

  • KMID: 2142893
  • Korean J Med.
  • 2013 Jun;84(6):802-803.
Zolpidem is one of commonly prescribed hypnotics in worldwide. Zolpidem is more favored than benzodiazepines because of its efficacy and safety profiles. However there were many reports those concerns about...
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Pathology of Thrombotic Microangiopathy

Sol MY

  • KMID: 2196618
  • J Korean Soc Pediatr Nephrol.
  • 2013 Apr;17(1):6-12.
Thrombotic microangiopathy (TMA) is a microvascular thrombotic lesion caused by endothelial injury and subsequent formation of platelet rich thrombus. TMA is first described as a classical pathologic feature of HUS/TTP....
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Comparison Between Beers Criteria and Screening Tool of Older Person's Prescriptions as a Screening Tool for the Detection of Potentially Inappropriate Medicines and Adverse Drug Events in the Elderly Patients

Lee JH, Roh JH, Suh YW, Lee JH, Lee ES, Lee BK, Kim KI, Kim CH

  • KMID: 2340254
  • J Korean Geriatr Soc.
  • 2013 Mar;17(1):28-36.
BACKGROUND: Beers criteria are used to identify the potentially inappropriate medications (PIMs) in elderly patients. However, the criteria have limitations such as lacking consideration of drug-drug and duplicated prescriptions. The...
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Lidocaine anaphylaxis and lidocaine-specific immunoglobulin E measurement

Yeo JY, Kim GE, Han JY, Im JH, Park SW, Kim CW

Although local anesthetics can cause adverse drug reactions (ADRs), most ADRs to local anesthetics are from vasovagal, toxic, or anxiety reactions, while immunoglobulin E (IgE)-mediated anaphylaxis is extremely rare. We...
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A Case of Levofloxacin-Induced Anaphylaxis With Elevated Serum Tryptase Levels

Lee JH, Lee WY, Yong SJ, Shin KC, Lee MK, Kim CW, Kim SH

Levofloxacin, a fluoroquinolone and L-isomer of the racemate ofloxacin, has been approved for the treatment of acute and chronic bacterial infections. Gastrointestinal complaints are the most frequently reported adverse drug...
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A Case of Bilateral Vestibular Hypofunction Following Oseltamivir Medication

Kim HY, Ahn SK, Hur DG

  • KMID: 1426906
  • Res Vestib Sci.
  • 2013 Mar;12(1):27-30.
The threat of pandemic influenza has focused attention and resources on virus surveillance, prevention, and containment. The World Health Organization has strongly recommended the use of the antiviral drug, Oseltamivir...
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Effect of Clinical Pharmacist Interventions on Prevention of Adverse Drug Events in Surgical Intensive Care Unit

Kang M, Kim A, Cho Y, Kim H, Lee H, Yu YJ, Lee H, Park KJ, Park HP

BACKGROUND: A pharmacist's participation in medical rounds in intensive care unit (ICU) is becoming popular nowadays. In this study, we investigated the effect of pharmacologic intervention by a pharmacist's participation...
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Management of vaccine safety in Korea

Choe YJ, Bae GR

  • KMID: 2391974
  • Clin Exp Vaccine Res.
  • 2013 Jan;2(1):40-45.
Although vaccination is regarded as one of the most effective public health measure to prevent and control infectious diseases, no vaccine is perfectly safe. Therefore, safety management is an essential...
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Opioid Pharmacotherapy for Chronic Noncancer Pain: The American Experience

Chapman CR

Chronic noncancer pain is a significant and growing public health challenge in the United States. Lacking effective alternative interventions for effective chronic noncancer pain management, many physicians have turned to...
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A Comparison of Active Surveillance Programs Including a Spontaneous Reporting Model for Phamacovigilance of Adverse Drug Events in a Hospital

Yun IS, Koo MJ, Park EH, Kim SE, Lee JH, Park JW, Hong CS

  • KMID: 2432937
  • Korean J Intern Med.
  • 2012 Dec;27(4):443-450.
BACKGROUND/AIMS: Spontaneous reporting systems have several weak points, such as low reporting rates and insufficient clinical information. Active surveillance programs, such as ward rounds and a clinical data repository (CDR),...
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CYP2C9 Mutation Affecting the Individual Variability of Warfarin Dose Requirement

Kim YB, Ko MJ, Lee DG, Do JG, Hwang JH

  • KMID: 2383663
  • Ann Rehabil Med.
  • 2012 Dec;36(6):857-860.
Warfarin is a frequently prescribed anticoagulant in rehabilitation patients. Adverse drug reactions of warfarin were reported as bleeding and cutaneous microvascular thrombosis. Major bleeding, such as intracranial hemorrhage and psoas...
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Statistical Analysis System of Spontaneous Adverse Drug Reaction Reports

Kim S, Wang B, Lee J, Kim B, La H, Park YM, Choi I

  • KMID: 2334535
  • J Korean Soc Clin Pharmacol Ther.
  • 2012 Dec;20(2):155-164.
BACKGROUND: Spontaneous adverse drug reaction (ADR) reporting data has been used for safety of post-market drug surveillance. A system has been required that is able to detect signals associated with...
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Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease

Yi GC, Yoon KH, Hwang JB

  • KMID: 2315351
  • Pediatr Gastroenterol Hepatol Nutr.
  • 2012 Dec;15(4):272-275.
We report here a case of drug-induced acute pancreatitis proved by elimination and single, low dose challenge test in a child with Crohn disease. A 14-year-old boy with moderate/severe Crohn...
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Persistent Complete Atrioventricular Block after Recovery from Acute Fulminant Myocarditis

Park BM, Seol SH, Park SH, Lee JW, Kim DK, Kim KH, Kim DI

  • KMID: 2263411
  • Korean J Med.
  • 2012 Nov;83(5):629-632.
Acute myocarditis can be caused by viral, bacterial, or protozoal infection, or drug toxicity. Fulminant myocarditis progresses rapidly and frequently leads to cardiogenic shock, so patients should be supported by...
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