- Natural radioprotectors and their impact on cancer drug discovery
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Kuruba V, Gollapalli P
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- Radiat Oncol J.
- 2018 Dec;36(4):265-275.
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Cancer is a complex multifaceted illness that affects different patients in discrete ways. For a number of cancers the use of chemotherapy has become standard practice. Chemotherapy is a use... -
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- Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery
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Park SJ, Im DS
- KMID: 2367621
- Biomol Ther.
- 2017 Jan;25(1):80-90.
- doi: 10.4062/biomolther.2016.160
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G... -
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- Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
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Kobet RA, Pan X, Zhang B, Pak SC, Asch AS, Lee MH
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- Biomol Ther.
- 2014 Sep;22(5):371-383.
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The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional... -
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- Intercellular Lipid Mediators and GPCR Drug Discovery
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Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
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- Pharmacogenomics in Drug Discovery and Development
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Ahn C
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- Genomics Inform.
- 2007 Jun;5(2):41-45.
Pharmacogenomics is the study that examines how genetic variations affect the ways in which people respond to drugs. The ways people respond to drugs are complex traits that are influenced... -
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- Evaluation of Advanced Structure-Based Virtual Screening Methods for Computer-Aided Drug Discovery
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Lee HS, Choi JW, Yoon SJ
- KMID: 2166251
- Genomics Inform.
- 2007 Mar;5(1):24-29.
Computational virtual screening has become an essential platform of drug discovery for the efficient identification of active candidates. Moleculardocking, a key technology of receptor-centric virtual screening, is commonly used to... -
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- Data Mining for High Dimensional Data in Drug Discovery and Development
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Lee KR, Park DC, Lin X, Eslava S
- KMID: 2053068
- Genomics Inform.
- 2003 Dec;1(2):65-74.
Data mining differs primarily from traditional data analysis on an important dimension, namely the scale of the data. That is the reason why not only statistical but also computer science... -
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