- The Levels of MDM2 Protein Are Decreased by a Proteasome-Mediated Proteolysis Prior to Caspase-3-Dependent pRb and PARP Cleavages
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Cho JW, Park JC, Lee JC, Kwon TK, Park JW, Baek WK, Suh SI, Suh MH
- KMID: 648246
- J Korean Med Sci.
- 2001 Apr;16(2):135-139.
- doi: 10.3346/jkms.2001.16.2.135
MDM2 is a substrate of caspase-3 in p53-mediated apoptosis. In addition, MDM2 mediates its own ubiquitination in a RING finger-dependent manner. Thus, we investigated whether MDM2 is degraded through a... -
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- Down-regulation of human FEN-1 gene expression during differentiation of promyelocytic leukemia cells
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Kim IS
- KMID: 755017
- Exp Mol Med.
- 1998 Dec;30(4):252-256.
Flap endo/exonuclease-1 (FEN-1) recognizes 5'-flap DNA structures that have been proposed to be important intermediates in DNA replication, repair and recombination, and cleaves the double strand-single strand junction of flap ... -
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- Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells
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Kim SA, Hong KJ
- KMID: 755077
- Exp Mol Med.
- 2000 Sep;32(3):135-140.
Thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, inhibits neovascularization and is implicated in the regression of tumor growth and metastasis. We found that the synthesis of TSP-1 in... -
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- Cross-linking of CD4 induces cytoskeletal association of CD4 and p56lck
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Ha-Lee YM, Lee YS, Kim YK, Sohn JW
- KMID: 927129
- Exp Mol Med.
- 2000 Mar;32(1):18-22.
A membrane glycoprotein CD4 functions as a co-receptor of a T lymphocyte. The co-receptor function has been attributed to a protein tyrosine kinase, p56lck, which is activated upon CD4 binding... -
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- Major house dust mite allergen, Der p I, activates phospholipase D in human peripheral blood mononuclear cells from allergic patients: involvement of protein kinase C
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Oh JW, Kim JH, Lee KS, Han JS
- KMID: 1109304
- Exp Mol Med.
- 2000 Jun;32(2):67-71.
The major house-dust-mite allergen, Der p I, stimulates the phospholipase D (PLD) in peripheral blood mononuclear cells (PBMC) from allergic patients with maximal responses after 30 min exposure. At 30... -
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