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Disulfiram, a Re-positioned Aldehyde Dehydrogenase Inhibitor, Enhances Radiosensitivity of Human Glioblastoma Cells In Vitro

Koh HK, Seo SY, Kim JH, Kim HJ, Chie EK, Kim SK, Kim IH

PURPOSE: Glioblastoma, the most common brain tumor in adults, has poor prognosis. The purpose of this study was to determine the effect of disulfiram (DSF), an aldehyde dehydrogenase inhibitor, on...
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Anti-tumor activity and mitochondrial stability of disulfiram in HL-60 cells

Disulfiram (DSF) is a member of the dithiocarbamate family that can bind copper. Recent studies have shown that DSF has anti-cancer activities, but the mechanism has not been clarified. Therefore,...
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Epileptic Seizure Due to Disulfiram Treatment

Erensoy H, Sargin AE

Disulfiram has been used for the treatment of alcohol dependence for nearly 65 years and is approved by the Food and Drug Administration. It causes negative reinforcement by accumulating toxic...
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Disulfiram Induced Psychosis

Mohapatra , Rath NR

Disulfiram is the commonly prescribed drug for the treatment of alcohol dependence. It's major metabolite (diethyldithiocarbamate) is an inhibitor of dopamine-betahydroxylase, an enzyme that catalyzes the metabolism of dopamine to...
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Disulfiram Implantation for the Treatment of Alcoholism: Clinical Experiences from the Plastic Surgeon's Point of View

Sezgin B, Sibar S, Bulam H, Findikcioglu K, Tuncer S, Dogan B

BACKGROUND: Disulfiram implantation is a widely used treatment alternative for alcohol abuse, yet reports on the surgical aspect of disulfiram implantation with respect to patient and drug-related treatment efficacy and...
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Reversible Motor Neuropathy Following Disulfiram Therapy

Park SW, Song SK, Lee JS, Choi JC, Kang JH, Kang SY

  • KMID: 2343541
  • J Korean Neurol Assoc.
  • 2014 Aug;32(3):225-227.
No abstract available.
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A Case of Vocal Cord Palsy Following Disulfiram Intoxication

Bae JS, Kim JY, Ahn JY, Kim MK, Kim BJ

  • KMID: 1626921
  • J Korean Neurol Assoc.
  • 2005 Jun;23(3):408-410.
A 49 year-old woman, who took a high dose of disulfiram for the purpose of suicide, presented with severe hoarseness, quadriparesis, and sensory loss of distal limbs. Laryngeal electromyography showed...
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Hypotension Caused by a Disulfiram-Alcohol Reaction

Lee SL, Ryu SY, Kim HY

  • KMID: 2194052
  • J Korean Soc Emerg Med.
  • 2002 Dec;13(4):575-577.
Disulfiram, or antabuse, is used in the treatment of chronic alcoholism since it causes an unpleasant aversive reaction to alcohol. It works by inactivating hepatic aldehyde dehydrogenase, leading to a...
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A Case of Embolic Cerebral Infarction Following Disulfiram Poisoning

Lim SH, Kim HJ, Shin HR, Kim CS, Lee J, Hah JS, Kim SJ

  • KMID: 2342888
  • J Korean Neurol Assoc.
  • 2001 May;19(3):294-297.
A 29 year old man without any noticeable past or familial history presented with left ACA and MCA territorial hemorrhagic infarction after consuming an overdose of disulfiram in a drunken...
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