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Restoration of the inflammatory gene expression by horse oil in DNCB-treated mice skin

Lee JC, Park GR, Choi BS, Lee Y, Han CH

The present study evaluated the anti-inflammatory effect of horse oil in 2, 4-dinitrochlorobenzene (DNCB)-treated BALB/c mice. After the application of DNCB, the mice showed atopic dermatitis symptoms, including severe erythema,...
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Quantitative determination of 12-hydroxyeicosatetraenoic acids by chiral liquid chromatography tandem mass spectrometry in a murine atopic dermatitis model

Hong SH, Han JE, Ko JS, Do SH, Lee EH, Cho MH

Atopic dermatitis, one of the most important skin diseases, is characterized by both skin barrier impairment and immunological abnormalities. Although several studies have demonstrated the significant relationship between atopic dermatitis...
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The Roles of Reactive Oxygen Species Produced by Contact Allergens and Irritants in Monocyte-derived Dendritic Cells

Byamba D, Kim TG, Kim DH, Je JH, Lee MG

BACKGROUND: Although reactive oxygen species (ROS) have been produced in both mouse bone marrow-derived dendritic cells (DCs) and XS-106 DCs by contact sensitizers and irritants in previous studies, the generation...
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A Novel Model for Human Atopic Dermatitis: Application of Repeated DNCB Patch in BALB/c Mice, in Comparison with NC/Nga Mice

Lee KS, Jeong ES, Heo SH, Seo JH, Jeong DG, Choi YK

The various murine models have contributed to the study of human atopic dermatitis (AD). However limitations of the models involve low reproducibility and long time to develop AD. In an...
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Developing an Atopic Dermatitis Model and the Effects of Actinidia Extract on Dermatitis in NC/Nga Mice

Joo YH, Won CH, Kim JY, Cho KH, Min KU, Kim KH

  • KMID: 2301936
  • Korean J Dermatol.
  • 2009 Oct;47(10):1105-1112.
BACKGROUND: Atopic dermatitis is a chronic itchy, inflammatory skin disease that usually relapses. Although the etiology of atopic dermatitis remains unclear, it has been shown that both Th1 and Th2...
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The Production and Functions of Reactive Oxygen Species in Mouse Bone Marrow-derived Dendritic Cells by Various Haptens and Irritants

Kim DS, Kim DH, Byamba D, Lee TH, Cho YH, Lee MG

  • KMID: 2248021
  • Korean J Dermatol.
  • 2008 Nov;46(11):1470-1477.
BACKGROUND: Various allergens and irritants induced the production of reactive oxygen species (ROS) in the well-established mouse dendritic cell (DC) line XS106 and this production of ROS was inhibited by...
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Two Cases of Alopecia Totalis treated with Diphenylcyclopropenone (DPCP) Immunotherapy

Moon SK, Shin YM, Kim CW, Shin DH, Choi JS, Kim KH

Treatments for alopecia areata include topical corticosteroid treatment, corticosteroid intralesional injection, systemic corticosteroid treatment, PUVA(psoralen-UVA) and topical immunotherapy. The therapeutic effects are variable. Alopecia totalis is hard to treat completely....
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A Case of Vitiligo Developed on the Sites of DNCB Application in a Patient with Alopecia Areata

Kim SS, Seo YJ, Kim KH, Kim KJ

  • KMID: 2086805
  • Korean J Dermatol.
  • 2004 Apr;42(4):452-455.
We report a case of vitiligo developed on the sites of DNCB application for the treatment of alopecia areata in a 53-year-old woman. Histopathologic studies of the depigmented patches showed...
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Combination Therapy with Griseofulvin and Immunotherap (DNCB, DPCP)on Plane Warts

Jeong SW, Cha SH, Park SD

  • KMID: 1548104
  • Korean J Dermatol.
  • 1999 Mar;37(3):320-324.
BACKGROUND: Although several kinds of treatment methods(destructive therapy, immunotherapy, etc) for plane warts have been attempted but there have been no entirely satisfactory treatments, because the plane wants are seen...
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Effect of Adjuvant Immunochemotherapy on Immunologic Function of Gastric Cancer Patients

Bae JM, Kim JP

  • KMID: 2005555
  • J Korean Surg Soc.
  • 1998 Aug;55(2):190-197.
BACKGROUND: We have postoperatively performed adjuvant immunochemotherapy (Picibanil plus oral -fluorouracil) for advanced gastric cancer patients. We aimed to study the effect of immunochemotherapy on the immunologic function after gastric...
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A Study on Therapeutic Experience for 267 Patients with Warts

Lee SC, Seo JJ, Kim M, Kim SJ, Won YH

  • KMID: 2172513
  • Chonnam Med J.
  • 1998 Jun;34(1):31-38.
The purpose of this study was to elucidate the clinical observation of warts in terms of therapeutic response to variable methods. 267 patients with warts were treated with dinitrochlorbenezene(DNCB), diphenylcyclopropenone(DPCP),...
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Cytosolic Glutathione S-Transferase Change after Deoxycholate Exposure in Colon Cancer Cell Lines

Park DK, Shin JH, Park SG, Cheung SY

  • KMID: 1835108
  • J Korean Soc Coloproctol.
  • 1998 Dec;14(4):701-708.
PURPOSE: Bile acids (especially deoxycholate) was known to be toxic and mutagenic on colon epithelium. They proposed at least four mechanisms for the bile acid toxicity. It is the one...
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The Effects of Korean Medical Drug on Lymphocyte Activity in Allergic Contact Dermatitis

Lee JH, Kim YH, Jung SJ, Jeong MH, Yee ST, Ahn SH, Kim JT, Lim YJ, Park IS

  • KMID: 1557255
  • Korean J Immunol.
  • 1998 Dec;20(4):459-466.
The purpose of this study was to elucidate the effects of Hwangyun, Hwangyunhaedogtang, and Kumeunhwa on the lymphocyte activity in allergic contact dermatitis induced by contact allergen 1-chloro-2,4-dinitrobenzene (DNCB) of...
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Contact Urticaria due to Dinitrochlorobenzene

Kim JK, Yoon TJ, Oh CW, Kim TH

A 33-year-old man with alopecia totalis presented with facial erythema and flares, conjunctival injection, and dyspnea developed within several minutes following the ninth application of dinitrochlorobenzene (DNCB). A scratch skin...
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Comparative Studies in the Therapeutic Effects between DNCB and DPCP in the Verruca Plana

Park JH, Kim SJ, Lee SC, Won YH, Chun IK

  • KMID: 2425597
  • Korean J Dermatol.
  • 1997 Dec;35(6):1082-1087.
This stuc1y was conducted to evaluate the therapeutic effect of immunotherapy on verruca plana. Forty-four patients with verruca plana were tried with dinitrochlorobenzene(DNCB) and diphenylcyclopropenone(DPCP) by topical application on the...
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A case of bowenoid papulosis treated with DNCB immunotherapy

Yu HD, Kim NI, Sim WY, Haw CR

  • KMID: 2230906
  • Korean J Dermatol.
  • 1992 Oct;30(5):669-673.
Bowenoid papulosis is manifested by clinically the benign-appearing papules of anogenital region and histopathologically similar features of squamous cellurar inoma in situ in human. A cause is thought to be...
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Immunotherapy of wart with dinitrochlorobenzene in children

Lee JH, Hong CK, Ro BI

  • KMID: 1692902
  • Korean J Dermatol.
  • 1991 Aug;29(4):500-505.
No abstract available.
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Mutiple Primary Malignant Tumor

Lee SJ, Chung YW, Kim HJ, Suh BY, Kwun KB

Though the occurrence of multiple primary malignant tumor is a rare finding but the reported cases of it has increased in recent years. We collected multiple primary cancer of different organ,...
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Effect of An Allergic Contact Dermatitis on the Irritant Response in Guinea Pigs

Seong YK, Eun HC

  • KMID: 2231471
  • Korean J Dermatol.
  • 1987 Aug;25(4):446-450.
The effect of an allergic contact dermatitis on the irritant was studied using DNCB(2. 5% in acetone) as the sensitizing agent and sodium lauryl sulfate of various concentrations (0. 5,...
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Induction of DNCB Oral Tolerance in Mice

Lee JY, Kang SB, Houh W

  • KMID: 2231467
  • Korean J Dermatol.
  • 1987 Aug;25(4):435-440.
Tolerance to contact hypersensitivity was induced by feeding of different DNCB doses in mice. A total of 40 mice were divided into 4 groups(control group, 6 mg feeding group, 10...
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