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Miltefosine-Induced Apoptotic Cell Death on Leishmania major and L. tropica Strains

Khademvatan S, Gharavi MJ, Rahim F, Saki J

The aim of this study was to assess the cytotoxic effects of various concentrations of miltefosine on Leishmania major (MRHO/IR/75/ER) and L. tropica (MHOM/IR/02/Mash10) promastigotes and to observe the programmed...
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Protective Effect of Ultra Low Molecular Weight Heparin on Glutamate-Induced Apoptosis in Cortical Cells

Yu TG, Zhang QZ, Zhang ZG, Wang WW, Ji SL, Du GH

PURPOSE: To investigate the effect of ultra low molecular weight heparin (ULMWH) on glutamate induced apoptosis in rat cortical cells and to explore the possible mechanisms. MATERIALS AND METHODS: Cell...
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Phytotherapeutic effects of Echinacea purpurea in gamma-irradiated mice

Abouelella AM, Shahein YE, Tawfik SS, Zahran AM

Echinacea (E.) purpurea herb is commonly known as the purple coneflower, red sunflower and rudbeckia. In this paper, we report the curative efficacy of an Echinacea extract in gamma-irradiated mice....
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Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death

Gong X, Wang M, Tashiro SI, Onodera S, Ikejima T

  • KMID: 1110127
  • Exp Mol Med.
  • 2006 Aug;38(4):428-434.
A terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay was used to determine that apoptosis causes HeLa cell death induced by pseudolaric acid B. The c-Jun N-terminal kinase (JNK) inhibitor...
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IL-1beta Acts in Synergy with Endogenous IL-1beta in A375-S2 Human Melanoma Cell Apoptosis Through Mitochondrial Pathway

Wang C, Wang MW, Tashiro SI, Onodera S, Ikejima T

Interleukin-1beta (IL-1beta) is a pivotal proinflammatory cytokine. To investigate the mechanism of IL-1beta-induced cell death in human malignant melanoma A375-S2 cells, MTT assay, photomicroscopical observation, DNA agarose gel electrophoresis, radioimmunoassay...
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Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3

Sung HJ, Choi SM, Yoon YS, An KS

  • KMID: 1029923
  • Exp Mol Med.
  • 1999 Dec;31(4):174-178.
Tanshinone II-A is a derivative of phenanthrene-quinone isolated from Salvia miltiorrhiza BUNGE, a traditional herbal medicine that is known to induce antiinflammatory, anti-oxidative and cytotoxic activity. We have...
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Iron-induced cytotoxicity in cultured rat retinal neurons

Sohn J, Yoon YH

Oxidative stress has been proposed as a major injury mechanism in the central nervous system including the retina. In this study, as an initial attempt to study the mechanism of...
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Nickel (II)-induced apoptosis and G2/M enrichment

Lee SH, Kim DK, Seo YR, Woo KM, Kim CS, Cho MH

  • KMID: 1109301
  • Exp Mol Med.
  • 1998 Sep;30(3):171-176.
Treatment with certain DNA-damaging agents induce a complex cellular response comprising pertubation of cell cycle progression and/or apoptosis on proliferating mammalian cells. Our studies were focused on the cellular effects of nickel (II)...
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