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Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism

Kim HL, Ha AW, Kim WK

BACKGROUND/OBJECTIVES: Excessive intake of simple sugars induces obesity and increases the risk of inflammation. Thus, interest in alternative sweeteners as a sugar substitute is increasing. The purpose of this study...
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Comparison of safety and analgesic efficacy of diclofenac sodium with etodolac after surgical extraction of third molars: a randomized, double-blind, double-dummy, parallel-group study

Vaghela JH, Shah JH, Patel JH, Purohit BM

BACKGROUND: Surgical extraction of third molars is associated with postoperative pain and swelling at the extraction site. Pain is commonly managed using non-steroidal anti-inflammatory drugs (NSAIDs). Postoperative pain is usually...
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Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells

Lee SE, Park HR, Jeon S, Han D, Park YS

OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via...
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Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats

Lee B, Yeom M, Shim I, Lee H, Hahm DH

Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but...
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15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells

Park JM, Na HK

BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that...
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The Effect of Saccharin on the Gene Expression of NF-κB and Inflammatory Cytokines in LPS-Stimulated SW480 Colon Cancer Cells

Choi H, Kim S, Kang H, Kim M, Kim W

There have been no published studies concerning the anti-inflammatory effects of corn silk on colon cancer cells. Thus, this study was conducted to investigate the effect of corn silk extract...
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Protective effect of Cordyceps militaris against hydrogen peroxide-induced oxidative stress in vitro

He MT, Lee AY, Park CH, Cho EJ

BACKGROUND/OBJECTIVES: Excessive production of reactive oxygen species (ROS) such as hydroxyl (·OH), nitric oxide (NO), and hydrogen peroxide (H2O2) is reported to induce oxidative stress. ROS generated by oxidative stress...
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4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages

Yoo OK, Keum YS

We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage...
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Baicalein Inhibits Dextran Sulfate Sodium-induced Mouse Colitis

Zhong X, Surh YJ, Do SG, Shin E, Shim KS, Lee CK, Na HK

BACKGROUND: Baicalein is a bioactive flavone that is originally extracted from the root of Scutellaria baicalensis Georgi. This plant has long served as Chinese herbal medicine in the management of...
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Anti-inflammatory effect of aged black garlic on 12-O-tetradecanoylphorbol-13-acetate-induced dermatitis in mice

You BR, Yoo JM, Baek SY, Kim MR

BACKGROUND/OBJECTIVES: Although aged black garlic has various biological activities such as anti-allergy, anti-inflammation and neuroprotection, effect of aged black garlic on chemically contact dermatitis is unclarified. MATERIALS/METHODS: To evaluate anti-dermatitic activity...
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Propofol Suppresses LPS-Induced Inflammation in Amnion Cells via Inhibition of NF-κB Activation

Yoon JY, Kim DW, Ahn JH, Choi EJ, Kim YH, Jeun M, Kim EJ

BACKGROUND: Preterm labor is a leading risk factor for neonatal death and long-term impairment and linked closely with inflammation. Non-obstetric surgery is occasionally needed during pregnancy and the anesthetic drugs...
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Anti-nociceptive and Anti-inflammatory Properties of Ilex latifolia and its Active Component, 3,5-Di-caffeoyl Quinic Acid Methyl Ester

Kim JY, Lee HK, Seong YH

The present study was conducted to investigate anti-nociceptive and anti-inflammatory effects of the leaves of Ilex latifolia Thunb (I. latifolia) in in vivo and in vitro. Writhing responses induced by...
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Anti-inflammatory Activity of Standardized Fraction from Inula helenium L. via Suppression of NF-κB Pathway in RAW 264.7 Cells

Chun J, Song K, Kim YS

Inula helenium L. is rich source of eudesmane-type sesquiterpene lactones, mainly alantolactone and isoalantolactone, which have the various pharmacological functions. In this study, we examined the inhibitory effects of nitric...
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Phenotypes of Severe Cutaneous Adverse Reactions Caused by Nonsteroidal Anti-inflammatory Drugs

Lee SY, Nam YH, Koh YI, Kim SH, Kim S, Kang HR, Kim MH, Lee JG, Park JW, Park HK, La HO, Kim MY, Park SJ, Kwon YE, Jung JW, Kim SH, Kim CW, Yang MS, Kang MG, Lee JY, Kim JH, Kim SH, Hur GY, Jee YK, Jin HJ, Park CS, Jeong YY, Ye YM

PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are common cause of severe cutaneous adverse reactions (SCARs). The present study aimed to investigate the characteristics of SCARs induced by NSAIDs in the Korean...
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Gene Expression in Cultured Keloid Fibroblasts

Kim DH, Kim UK, Choi KH, Park K

  • KMID: 2440723
  • Korean J Dermatol.
  • 2019 Feb;57(2):59-65.
BACKGROUND: Keloids are the result of an overgrowth of dense fibrous tissue. The mechanisms involved in keloid formation remain unknown. OBJECTIVE: To understand the mechanism of keloid formation, differences in gene...
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Effects of remifentanil preconditioning on factors related to uterine contraction in WISH cells

Kim CH, Lee SH, Kim EJ, Ahn JH, Choi EJ, Yoon JU, Choi IS

BACKGROUND: Preterm labor and miscarriage may occur in stressful situations, such as a surgical operation or infection during pregnancy. Pharyngeal and buccal abscess and facial bone fractures are inevitable dental...
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Rhodanthpyrone A and B play an anti-inflammatory role by suppressing the nuclear factor-κB pathway in macrophages

Kim KS, Han CY, Han YT, Bae EJ

Macrophage-associated inflammation is crucial for the pathogenesis of diverse diseases including metabolic disorders. Rhodanthpyrone (Rho) is an active component of Gentiana rhodantha, which has been used in traditional Chinese medicine...
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Antinociceptive and anti-inflammatory effects of N-acetylcysteine and verapamil in Wistar rats

Elberry AA, Sharkawi S, Wahba MR

BACKGROUND: Antinociceptive anti-inflammatory drugs have many adverse effects. The goal of this investigation is to study the probable anti-inflammatory and analgesic effects of verapamil and N-acetylcysteine (NAC) in experimental rats. METHODS:...
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Acer okamotoanum Inhibit the Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells

Choi SY, Kim JH, Quilantang NG, Lee S, Cho EJ

Chronic oxidative stress due to the accumulation of reactive oxygen species (ROS) in neuronal cells ultimately leads to neurodegenerative diseases. The use of natural therapies for the prevention of ROS-induced...
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Quantitative analysis of COX-2 promoter methylation in gastric carcinoma

Kim HG, Ryu SY, Lee KH, Lee JH, Kim DY

PURPOSE: To determine the occurrence of COX-2 methylation in gastric carcinoma (GC), the status and level of CpG methylation in the promoter region of cyclooxygenase-2 (COX-2) were analyzed in early...
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