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Intensivists' Direct Management without Residents May Improve the Survival Rate Compared to High-Intensity Intensivist Staffing in Academic Intensive Care Units: Retrospective and Crossover Study Design

Kim JH, Kim J, Bae S, Lee T, Ahn JJ, Kang BJ

BACKGROUND: Medical staff members are concentrated in the intensive care unit (ICU), and medical residents are essentially needed to operate the ICU. However, the recent trend has been to restrict...
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A “Back Light System” for Identification of Sites for Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Solid Pancreatic Masses: A Prospective, Randomized Study with a Crossover Design

Harada R, Kato H, Fushimi S, Inoue H, Uchida D, Akimoto Y, Tomoda T, Matsumoto , Noma Y, Yamamoto N, Horiguchi , Tsutsumi K, Okada H

BACKGROUND/AIMS: We applied a back light system (BLS) with a magnifying glass to improve the ability to assess the adequacy of specimen sampling using endosonography. We conducted this study to...
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A Comparative Study on Learning Outcomes according to the Integration Sequences of S-PBL in Nursing Students: Randomized Crossover Design

Yun SY, Choi JY

PURPOSE: This study aimed to compare the effects of simulation integrated with problem based learning (S-PBL) according to the sequences of problem-based learning (PBL) and high fidelity simulation training (HFS)...
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Pharmacokinetic comparison between fixed-dose combination of fimasartan/amlodipine 60/10 mg and the corresponding loose combination through partial replicated crossover study in healthy subjects

Yang E, Lee S, Lee H, Hwang I, Jang IJ, Yu KS, Lee S

Combination therapies of antihypertensive drugs are recommended in cases where hypertension is not controlled by monotherapy. This study aimed to compare the pharmacokinetics (PKs) between fixed-dose combination (FDC) of fimasartan/amlodipine...
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Pharmacokinetics comparison of solifenacin tartrate and solifenacin succinate: a randomized, open-label, single-dose, 2-way crossover study in healthy male volunteers

Kim YM, Jeon JY, Moon SJ, Jung J, Son H, Kim MG

Solifenacin is a muscarinic antagonist indicated for the treatment of overactive bladder with symptoms. Solifenacin tartrate is a newly developed salt formulation of solifenacin. This study compared the pharmacokinetic and...
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A Single-center, Prospective, Cross-over Study to Compare the Efficiency of Oxygen Supply between the OxyMaskâ„¢ and Non-rebreather Mask in Healthy Adults

Shin HJ, Choi JH, Lee JW, Moon HJ, Park SH, Jeong DK, Lee DW, Song JH, Lee BR

PURPOSE: In this single-center, prospective, randomized, cross-over study, we compared the efficiency of oxygen supply between OxyMask and non-rebreather mask (NRM), depending on the position of the mask. METHODS: Either OxyMask...
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Pharmacokinetics of atorvastatin and sustained-release metformin fixed-dose combination tablets: two randomized, open-label, 2-way crossover studies in healthy male subjects under fed conditions

Choi YK, Park SE, Kim EY, Park HJ, Kim EJ, Song GS, Ghim JL

Two separate studies were conducted to establish bioequivalence (BE) for two doses of atorvastatin/metformin sustained-release (SR) fixed dose combination (FDC) versus the same dosage of the individual component (IC) tablets...
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A Double-Blind, Randomized, Crossover Study to Compare the Effectiveness of Montelukast on Atopic Dermatitis in Korean Children

Jeon YH, Min TK, Yang HJ, Pyun BY

PURPOSE: Some studies report a role of leukotrienes in the pathogenesis of atopic dermatitis and suggest a rationale for the use of leukotriene receptor antagonist (LTRA) in the treatment of...
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The amelioration of plasma lipids by Korean traditional confectionery in middle-aged women: A cross-over study with western cookie

Hong SH, Kim M, Woo M, Noh JS, Lee J, Chung L, Song YO

BACKGROUND/OBJECTIVES: The purpose of this study was to examine whether plasma lipid profiles are affected differently by snack kinds with equal calorific values. SUBJECTS/METHODS: We compared a Korean traditional confectionery (dasik)...
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The flavor and acceptability of six different potassium-enriched (sodium reduced) iodized salts: a single-blind, randomized, crossover design

Maleki A, Soltanian , Zeraati F, Sheikh V, Poorolajal J

BACKGROUND: Hypertension is a serious public health problem. Potassium-enriched salt is suggested as a tool for lowering blood pressure. However, its flavor and taste acceptability is essential for population-based salt...
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Bioequivalence of Generic and Brand Name Clozapine in Korean Schizophrenic Patients: A Randomized, Two-Period, Crossover Study

Woo YS, Wang HR, Yoon BH, Lee SY, Lee KH, Seo JS, Bahk WM

OBJECTIVE: Clozapine is the treatment of choice for refractory schizophrenia. The aim of this study was to compare the pharmacokinetics of the brand name (Clozaril) formulation and a generic formulation (Clzapine)...
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Pharmacokinetics and bioequivalence of two different 20 mg olmesartan tablets: A randomized, single-dose, two-period crossover study in healthy Korean male volunteers

Lee J, Kim A, Yu KS, Chung JY, Yim SV, Kim BH

Olmesartan is an angiotensin receptor blocker (ARB) and is widely used in clinical practice to treat hypertension. To compare the pharmacokinetic (PK) parameters and tolerability of two oral formulations of...
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Comparisons on Efficacy of Elcatonin and Limaprost Alfadex in Patients with Lumbar Spinal Stenosis and Concurrent Osteoporosis: A Preliminary Study Using a Crossover Design

Kanchiku T, Imajo Y, Suzuki H, Yoshida Y, Taguchi T, Tominaga T, Toyoda K

STUDY DESIGN: Multicenter prospective study with a crossover design. PURPOSE: The objective of this study is to compare the efficacy of limaprost alfadex (LP) and elcatonin (EL) for lumbar spinal stenosis...
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Effects of Chili Treatment on Gastrointestinal and Rectal Sensation in Diarrhea-predominant Irritable Bowel Syndrome: A Randomized, Double-blinded, Crossover Study

Aniwan S, Gonlachanvit S

  • KMID: 2381199
  • J Neurogastroenterol Motil.
  • 2014 Jul;20(3):400-406.
BACKGROUND/AIMS: Whether, chronic chili ingestion can desensitize transient receptor potential vanilloid type 1 receptors in gastrointestinal (GI) tract leading to decrease GI symptoms and sensation in diarrhea-predominant irritable bowel syndrome...
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Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations in Patients with Schizophrenia: A Randomized Controlled, Cross-over Study

Kim EJ, Yeo S, Hwang I, Park JI, Cui Y, Jin HM, Kim HT, Hwang TY, Chung YC

OBJECTIVE: A randomized double-blind cross-over trial was conducted in patients with persistent auditory hallucinations (AHs) to investigate whether bilateral repetitive transcranial magnetic stimulation (rTMS) at the temporoparietal area or Broca's...
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A randomized crossover study of single biweekly administration of epoetin-alpha compared with darbepoetin-alpha in chronic kidney disease patients not receiving dialysis

Na HY, Lee YK, Shin SK, Yang DH, Cheon W, Park JH, Lee JH, Song JO, Jo YI

BACKGROUND: Recent evidence demonstrates that high doses of epoetin-alpha (EPO-alpha) can be administrated at extended intervals, despite its relatively short serum half-life. However, no prospective randomized trials on the effects...
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On comparison of SAS codes with GLM and MIXED for the crossover studies with QT interval data

Choi K, Hong T, Lee J

The structural complexity of crossover studies for bioequivalence test confuses analysts and leaves them a hard choice among various programs. Our study reviews PROC GLM and PROC MIXED in SAS...
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Bioequivalence of HCP1104, a New Fixed Dose Combination Drug and Co-administration of Eperisone 50 mg and Aceclofenac 100 mg: A Partial Replicated Crossover Study Design to Estimate the Pharmacokinetics of Highly Variable Drugs

Kim MJ, Kim YH, Choi HY, Jeon HS, Noh YH, Lim HS, Bae KS

BACKGROUND: This clinical study was conducted to compare pharmacokinetics of eperisone and aceclofenac of HCP1104, a new fixed dose combination drug with those in co-administration of eperisone 50 mg and...
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Efficacy and safety of high dose epoetin alfa therapy in CAPD patients by cross-over study

Do JH, Kim DJ, Choi SY, Do YS, Jang EH, Baek HJ, Kim JI, Yeo HM, Choi SC, Lee JE, Huh WS, Kim YG, Oh HY

  • KMID: 2305953
  • Korean J Med.
  • 2006 Nov;71(5):527-534.
BACKGROUND: Recombinant human erythropoietin (rHuEPO) is an essential and well-established treatment for renal anemia. Rcently, clinicians have moved toward administration of high dose rHuEPO to reduce the inconvenience and time...
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Comparison of Effects of Alcohol on Daytime Sleepiness, Psychomotor Performance, and Subjective Response according to ALDH2 Genotype in Healthy Young Men: A Double-Blind Placebo-Controlled Crossover Study

Shin HY, Shin IS

  • KMID: 2287264
  • Korean J Psychopharmacol.
  • 2006 Jan;17(1):70-80.
OBJECTIVE: This study aimed to investigate the effects of alcohol on daytime sleepiness, psychomotor performance, and subjective response in healthy young men with different ALDH2 genotypes. METHODS: A total of 24...
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