- A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement
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Choi SI, Jang MA, Jeong WJ, Jeon BR, Lee YW, Shin HB, Hong DS, Lee YK
- KMID: 2373620
- Ann Lab Med.
- 2017 Jan;37(1):77-80.
- doi: 10.3343/alm.2017.37.1.77
No abstract available. -
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- Frequency and Clinical Characteristics of Intrachromosomal Amplification of Chromosome 21 in Korean Childhood B-lineage Acute Lymphoblastic Leukemia
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Kim J, Lyu CJ, Shin S, Lee ST, Choi JR
- KMID: 2373579
- Ann Lab Med.
- 2016 Sep;36(5):475-480.
- doi: 10.3343/alm.2016.36.5.475
BACKGROUND: Intrachromosomal amplification of chromosome 21 (iAMP21) is known to be associated with poor prognosis in B-cell ALL (B-ALL). To determine the frequency and clinical characteristics of iAMP21 in Korean... -
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- A Novel KIT INDEL Mutation in Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1
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Lee JH, Park C, Kim SH, Shin MG
- KMID: 2373559
- Ann Lab Med.
- 2016 Jul;36(4):371-374.
- doi: 10.3343/alm.2016.36.4.371
No abstract available. -
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- Diagnostic Utility of Multiprobe Fluorescence in situ Hybridization Assay for Detecting Cytogenetic Aberrations in Acute Leukemia
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Kim BR, Choi JL, Kim JE, Woo KS, Kim KH, Kim JM, Kim SH, Han JY
- KMID: 1791920
- Ann Lab Med.
- 2014 May;34(3):198-202.
- doi: 10.3343/alm.2014.34.3.198
BACKGROUND: Specific cytogenetic aberrations detected by conventional karyotyping or FISH play a major role in the diagnosis, prognosis, and treatment of patients with acute leukemia. The FISH technique enhances the... -
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- A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)
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Moon Y, Horsman DE, Humphries , Park G
- KMID: 1493618
- Immune Netw.
- 2013 Oct;13(5):222-226.
- doi: 10.4110/in.2013.13.5.222
Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation... -
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- The Utility of the Multiplex Reverse Transcriptase-Polymerase Chain Reaction Assay in the Detection of Hematologic Malignancies
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Kim MJ, Cho SY, Lee WI, Park TS, Lee HJ
- KMID: 1707242
- Ann Lab Med.
- 2013 Jul;33(4):304-307.
- doi: 10.3343/alm.2013.33.4.304
No abstract available. -
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- Myeloid Sarcoma in Patients with RUNX1/RUNX1T1 Positive AML and a c-kit Mutation
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Yun YS, Choi SH, Yoo SH, Yu JS, Lee JE, Kim HJ, Min WS
- KMID: 2263747
- Korean J Med.
- 2011 Oct;81(4):517-525.
t (8;21)(q22;q22) is the most frequently detected cytogenetic abnormality in patients with acute myeloid leukemia (AML) and accounts for 8-21% of de novo AML. The translocation involves two genes, RUNX1... -
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- Spectra of Chromosomal Aberrations in 325 Leukemia Patients and Implications for the Development of New Molecular Detection Systems
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Choi HJ, Kim HR, Shin MG, Kook H, Kim HJ, Shin JH, Suh SP, Ryang DW
- KMID: 1094259
- J Korean Med Sci.
- 2011 Jul;26(7):886-892.
- doi: 10.3346/jkms.2011.26.7.886
This study investigated the spectrum of chromosomal abnormalities in 325 leukemia patients and developed optimal profiles of leukemic fusion genes for multiplex RT-PCR. We prospectively analyzed blood and bone marrow... -
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- Prognostic Significance of TEL/AML1 Rearrangement and Its Additional Genetic Changes in Korean Childhood Precursor B-Acute Lymphoblastic Leukemia
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Chung HY, Kim KH, Jun KR, Jang S, Park CJ, Chi HS, Im HJ, Seo JJ, Seo EJ
- KMID: 1096811
- Korean J Lab Med.
- 2010 Feb;30(1):1-8.
- doi: 10.3343/kjlm.2010.30.1.1
BACKGROUND: TEL (ETV6)/AML1 (RUNX1) rearrangement is observed in approximately 20-25% of childhood precursor B-ALL and is associated with a favorable outcome. Additional genetic changes, associated with TEL/AML1, are frequently found.... -
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- Near-tetraploidy Acute Myeloid Leukemia with RUNX1-RUNX1T1 Rearrangement Due to Cryptic t(8;21)
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Im M, Lee JK, Lee DY, Hong YJ, Hong SI, Kang HJ, Chang YH
- KMID: 1781603
- Korean J Lab Med.
- 2009 Dec;29(6):510-514.
- doi: 10.3343/kjlm.2009.29.6.510
Tetraploidy or near-tetraploidy is a rare cytogenetic abnormality found in AML, and is divided into primary and secondary forms. The secondary tetraploidy or near-tetraploidy found in AML is known to... -
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- Clinical Utility of Fluorescence in-situ Hybridization Profile Test in Detecting Genetic Aberrations in Acute Leukemia
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Kim SR, Kim HJ, Kim SH
- KMID: 1077410
- Korean J Lab Med.
- 2009 Oct;29(5):371-378.
- doi: 10.3343/kjlm.2009.29.5.371
BACKGROUND: Cytogenetic abnormalities are one of the most reliable prognostic factors in acute leukemia. Combination of conventional chromosome analysis (CCA) and FISH provides higher sensitivity in detecting these genetic abnormalities,... -
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- Putative association of RUNX1 polymorphisms with IgE levels in a Korean population
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Chae SC, Park BL, Park CS, Ryu HJ, Yang YS, Lee SO, Choi YH, Kim EM, Uh ST, Kim YH, Kim KK, Oh B, Chung HT, Kimm K, Shin HD
- KMID: 1098093
- Exp Mol Med.
- 2006 Oct;38(5):583-588.
RUNX1, a member of the runt domain gene family of transcription factors, encodes a heterodimeric transcription factor and regulates the expression of various genes related to hematopoiesis and myeloid differentiation.... -
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- Prognostic Value of AML1/ETO Fusion Transcripts in Patients with Acute Myelogenous Leukemia
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Cho EK, Bang SM, Ahn JY, Yoo SM, Park PW, Seo YH, Shin DB, Lee JH
- KMID: 759629
- Korean J Intern Med.
- 2003 Mar;18(1):13-20.
BACKGROUND: The t (8; 21) (q22; q22), which produces the fusion gene AML1/ETO, is associated with relatively good prognosis and, in particular, with a good response to cytosine arabinoside. Analysis... -
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