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Induction of colorectal carcinogenesis in the C57BL/6J and A/J mouse strains with a reduced DSS dose in the AOM/DSS model

Arnesen H, Müller MHB, Aleksandersen M, Østby GC, Carlsen H, Paulsen JE, Boysen P

Background: Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide and thus mouse models of CRC are of significant value to study the pathogenesis. The Azoxymethane/Dextran sulfate...
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Clinical characteristics and survival of colorectal cancer patients in Korea stratified by age

Baek SK, Lee JS, Hwang IG, Kim JG, Kim TW, Sohn SK, Kang MY, Lee SC

Background/Aims: This nationwide study was undertaken to determine differences in clinicopathologic characteristics and survival of patients with colorectal cancer (CRC) according to age using big data from the Korean National...
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LASSO-Based Machine Learning Algorithm for Prediction of Lymph Node Metastasis in T1 Colorectal Cancer

Kang J, Choi YJ, Kim Ik, Lee HS, Kim H, Baik SH, Kim NK, Lee KY

Purpose The role of tumor-infiltrating lymphocytes (TILs) in predicting lymph node metastasis (LNM) in patients with T1 colorectal cancer (CRC) remains unclear. Furthermore, clinical utility of a machine learning–based approach...
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Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Obstructing Colorectal Cancer Treated by Endoscopic Stenting as a Bridge to Surgery

Guo J, Chok AY, Lim HJ, Tay WX, Lye WK, Samarakoon LB, Tan EJ, Mathew R

Purpose: Neutrophil-to-lymphocyte ratio (NLR) has been reported to predict adverse survival outcomes among patients with colorectal cancer (CRC). This study evaluates the prognostic value of NLR among patients with obstructing...
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Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction

Herrero A, Benedicto A, Romayor I, Olaso E, Arteta B

Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE 2 secretion....
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Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals

Shen W, Sun J, Li Z, Yao F, Lin K, Jiao X

Background/Aim: It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types...
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Clinical practice guideline for endoscopic resection of early gastrointestinal cancer

Park CH, Yang DH, Kim JW, Kim JH, Kim JH, Min YW, Lee SH, Bae JH, Chung H, Choi KD, Park JC, Lee H, Kwak MS, Kim B, Lee HJ, Lee HS, Choi M, Park DA, Lee JY, Byeon JS, Park CG, Cho JY, Lee ST, Chun HJ

Although surgery was the standard treatment for early gastrointestinal cancers, endoscopic resection is now a standard treatment for early gastrointestinal cancers without regional lymph node metastasis. High-definition white light endoscopy,...
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Dysregulated Free Fatty Acid Receptor 2 Exacerbates Colonic Adenoma Formation in ApcMin/+ Mice: Relation to Metabolism and Gut Microbiota Composition

Huang YW, Lin CW, Pan P, Echeveste CE, Dong A, Oshima K, Yearsley M, Yu J, Wang LS

Free fatty acid receptor 2 (FFAR2) has been reported as a tumor suppressor in colon cancer development. The current study investigated the effects of FFAR2 signaling on energy metabolism and...
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Sex difference in bowel preparation quality and colonoscopy time

Hwang YJ, Shin DW, Kim N, Yoon H, Shin CM, Park YS, Lee DH

Background/Aims: The length of colon is known to be longer in females than in males. In addition, the morphology of colon cancer is different between males and females. The aim...
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Clinical relevance and prognostic role of preoperative cell-free single-stranded DNA concentrations in colorectal cancer patients

Song HS, Kang DH, Kim H, Ahn TS, Kim TW, Baek MJ

Purpose: Circulating cell-free single-stranded DNA (ccf-ssDNA) is extracellular DNA and it is a useful biomarker for the diagnosis of tumors and predicting the prognosis of tumors. However, the clinical usefulness...
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Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer

Kim YJ, Kim CH

From the perspective of survival outcomes, the cancer survival of colorectal cancer (CRC) in the whole stage has improved. Peritoneal metastasis (PM) is found in approximately 8% to 15% of...
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Recent Advance in the Management of Dysplasia in the Ulcerative Colitis

Yang DH

In patients having long-standing ulcerative colitis (UC), the risk of colorectal cancer (CRC) increased compared with general population. Dysplasia is a precancerous lesion of colitic patients, and traditionally total proctocolectomy...
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The Influence of Self Esteem and Sexual Communication on Sexual Satisfaction of Colorectal Cancer Women with Ostomy

An HJ, Kang SJ

Purpose: The purpose of this study was to identify the influence of self-esteem and sexual communication on sexual satisfaction among female colorectal cancer patients with ostomy. Methods: A cross-sectional descriptive study...
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Risk Stratification of T1 Colorectal Cancer Metastasis to Lymph Nodes: Current Status and Perspective

Ichimasa K, Kudo Se, Miyachi H, Kouyama Y, Misawa M, Mori Y

With the widely spreading population-based screening programs for colorectal cancer and recent improvements in endoscopic diagnosis, the number of endoscopic resections in subjects with T1 colorectal cancer has been increasing....
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Medications and the Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases: Use of the Landmark Method

Choi YY, Lee JK, Kim HS, Kim DW, Kim HM, Kang DR

Purpose: This study aimed to determine whether the use of drugs in the treatment of inflammatory bowel disease is related to the risk of colorectal cancer using a Cox proportional...
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Prognostic implication of systemic inflammatory markers in young patients with resectable colorectal cancer

Lee Sy, Lee SI, Min BW, Oh SC

Purpose: The prognosis of young colorectal cancer (CRC) patients has not fully been addressed. The prognostic significance of systemic inflammatory markers was examined in those patients. Methods: A total of 965...
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Robotic pelvic exenteration and extended pelvic resections for locally advanced or synchronous rectal and urological malignancy

Williams M, Perera M, Nouhaud FX, Coughlin G

Purpose: To describe the surgical technique and examine the feasibility and outcomes following robotic pelvic exenteration and extended pelvic resection for rectal and/or urological malignancy. Materials and Methods: We present a...
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Trends of Colorectal Cancer Prevalence in Kazakhstan Related to Screening

Zhylkaidarova A, Kaidarova D, Batyrbekov K, Shatkovskaya O, Begimbetova D

We carried out an analysis of the total incidence of colon cancer throughout Kazakhstan. Retrospectively, according to the regional reports on endoscopic screening, the study showed an increase in the...
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The Usefulness of Preoperative Colonoscopic Tattooing with Autologous Blood for Localization in Laparoscopic Colorectal Surgery

Yeo UD, Sung NS, Roh SJ, Choi WJ, Song KH, Choi IS, Yoon DS, Lee SE, Moon JI, Kwon SU, Bae IE, Lee SJ

Purpose: In colorectal cancer surgery, it is important to have accurate resection margins. However, it is challenging to localize lesions during laparoscopy. Therefore, to reduce surgical errors, many preoperative localizing...
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Preoperative Colonoscopic Tattooing with Autologous Blood in Laparoscopic Colorectal Cancer Surgery: Red-Flagging for an Invisible Enemy

Lee J, Oh HK

In patients with early colorectal cancer, intraoperative localization of the target lesion is troublesome. Several strategies have also been studied for the preoperative localization of colorectal tumors. These include CT...
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